Sugi Variant

Sugi Variant/CDON

CDON — 795 ClinVar variants

All ClinVar germline CDON variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 341 flagged for review →

3 Pathogenic · 2 Likely pathogenic · 33 Conflicting · 159 Benign · 19 Benign/Likely benign · 144 Likely benign · 435 Uncertain significance

Full CDON gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 341

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 3

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 19

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 212

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 212

Predictors split 107

The independent predictors disagree with each other — read with care.

All CDON variants

Pathogenic 3

Likely pathogenic 2

Conflicting classifications of pathogenicity 33

Benign 159

Benign/Likely benign 19

Likely benign 144

Uncertain significance 435

Showing the top 300 by review status; the full set is in the sitemap.