Sugi Variant

Sugi Variant/CDT1

CDT1 — 521 ClinVar variants

All ClinVar germline CDT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 255 flagged for review →

18 Pathogenic · 2 Pathogenic/Likely pathogenic · 6 Likely pathogenic · 16 Conflicting · 43 Benign · 11 Benign/Likely benign · 181 Likely benign · 244 Uncertain significance

Full CDT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 255

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 3

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 99

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 151

The independent predictors disagree with each other — read with care. · showing the 150 best-reviewed of 151

All CDT1 variants

Pathogenic 18

Pathogenic/Likely pathogenic 2

Likely pathogenic 6

Conflicting classifications of pathogenicity 16

Benign 43

Benign/Likely benign 11

Likely benign 181

Uncertain significance 244