CEACAM4 — 41 ClinVar variants
All ClinVar germline CEACAM4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
3 Likely benign · 38 Uncertain significance
Full CEACAM4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CEACAM4 p.Ala127Thr Uncertain significance Single submitter
- CEACAM4 p.Ala182Ser Uncertain significance Single submitter
- CEACAM4 p.Asp116Gly Uncertain significance Single submitter
- CEACAM4 p.Asp130Asn Uncertain significance Single submitter
- CEACAM4 p.Asp132Asn Uncertain significance Single submitter
- CEACAM4 p.Asp237Asn Uncertain significance Single submitter
- CEACAM4 p.Cys234Ser Uncertain significance Single submitter
- CEACAM4 p.His12Gln Uncertain significance Single submitter
- CEACAM4 p.His29Arg Uncertain significance Single submitter
- CEACAM4 p.Ile62Val Uncertain significance Single submitter
- CEACAM4 p.Lys49Arg Uncertain significance Single submitter
- CEACAM4 p.Phe27Ser Uncertain significance Single submitter
- CEACAM4 p.Pro192Leu Uncertain significance Single submitter
- CEACAM4 p.Pro193Ser Uncertain significance Single submitter
- CEACAM4 p.Pro3Ala Uncertain significance Single submitter
- CEACAM4 p.Pro3Ser Uncertain significance Single submitter
- CEACAM4 p.Pro3Thr Uncertain significance Single submitter
- CEACAM4 p.Pro4Arg Uncertain significance Single submitter
- CEACAM4 p.Pro91Thr Uncertain significance Single submitter
- CEACAM4 p.Val167Met Uncertain significance Single submitter
- CEACAM4 p.Val242Ala Uncertain significance Single submitter
- CEACAM4 p.Val243Ala Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- CEACAM4 p.Ala80Val Uncertain significance Single submitter
- CEACAM4 p.Arg98Gln Uncertain significance Single submitter
- CEACAM4 p.Arg9Cys Uncertain significance Single submitter
- CEACAM4 p.Asn111Asp Uncertain significance Single submitter
- CEACAM4 p.Cys172Trp Uncertain significance Single submitter
- CEACAM4 p.Glu39Gly Uncertain significance Single submitter
- CEACAM4 p.Glu47Lys Uncertain significance Single submitter
- CEACAM4 p.Gly151Arg Uncertain significance Single submitter
- CEACAM4 p.Ile125Thr Uncertain significance Single submitter
- CEACAM4 p.Ile83Thr Uncertain significance Single submitter
- CEACAM4 p.Leu114Val Uncertain significance Single submitter
- CEACAM4 p.Lys49Asn Uncertain significance Single submitter
- CEACAM4 p.Phe27Leu Uncertain significance Single submitter
- CEACAM4 p.Phe36Leu Likely benign Single submitter
- CEACAM4 p.Pro220Leu Uncertain significance Single submitter
- CEACAM4 p.Ser96Cys Uncertain significance Single submitter
- CEACAM4 p.Thr72Met Uncertain significance Single submitter
All CEACAM4 variants
Likely benign 3
- p.Phe36Leu Single submitter ⚠
- p.Pro30Leu Single submitter
- p.Val153Ile Single submitter
Uncertain significance 38
- p.Ala127Thr Single submitter ⚠
- p.Ala182Ser Single submitter ⚠
- p.Ala80Val Single submitter ⚠
- p.Arg98Gln Single submitter ⚠
- p.Arg9Cys Single submitter ⚠
- p.Asn111Asp Single submitter ⚠
- p.Asp116Gly Single submitter ⚠
- p.Asp130Asn Single submitter ⚠
- p.Asp132Asn Single submitter ⚠
- p.Asp237Asn Single submitter ⚠
- p.Cys172Trp Single submitter ⚠
- p.Cys234Ser Single submitter ⚠
- p.Glu39Gly Single submitter ⚠
- p.Glu47Lys Single submitter ⚠
- p.Gly151Arg Single submitter ⚠
- p.His12Gln Single submitter ⚠
- p.His29Arg Single submitter ⚠
- p.Ile125Thr Single submitter ⚠
- p.Ile62Val Single submitter ⚠
- p.Ile83Thr Single submitter ⚠
- p.Leu114Val Single submitter ⚠
- p.Lys49Arg Single submitter ⚠
- p.Lys49Asn Single submitter ⚠
- p.Phe27Leu Single submitter ⚠
- p.Phe27Ser Single submitter ⚠
- p.Pro192Leu Single submitter ⚠
- p.Pro193Ser Single submitter ⚠
- p.Pro220Leu Single submitter ⚠
- p.Pro3Ala Single submitter ⚠
- p.Pro3Ser Single submitter ⚠
- p.Pro3Thr Single submitter ⚠
- p.Pro4Arg Single submitter ⚠
- p.Pro91Thr Single submitter ⚠
- p.Ser96Cys Single submitter ⚠
- p.Thr72Met Single submitter ⚠
- p.Val167Met Single submitter ⚠
- p.Val242Ala Single submitter ⚠
- p.Val243Ala Single submitter ⚠