CEBPZ — 172 ClinVar variants

All ClinVar germline CEBPZ variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 161 flagged for review →

11 Likely benign · 161 Uncertain significance

Full CEBPZ gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 161

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 110

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 51

The independent predictors disagree with each other — read with care.

All CEBPZ variants

Likely benign 11

p.Arg310His Single submitter
p.Asn301Ser Single submitter
p.Asp891Gly Single submitter ⚠
p.Ile68Val Single submitter
p.Leu427= Single submitter
p.Phe312= Single submitter
p.Val270Leu Single submitter
p.Val464Ile Single submitter
p.Val4Ala Single submitter
p.Val678Ile Single submitter
p.Val870Met Single submitter

Uncertain significance 161

p.Ala1008Thr Single submitter ⚠
p.Ala2Ser Single submitter ⚠
p.Ala2Val Single submitter ⚠
p.Ala365Val Single submitter ⚠
p.Ala369Ser Single submitter ⚠
p.Ala382Val Single submitter ⚠
p.Ala3Ser Single submitter ⚠
p.Ala3Val Single submitter ⚠
p.Ala94Thr Single submitter ⚠
p.Ala957Asp Single submitter ⚠
p.Arg1019Ser Single submitter ⚠
p.Arg17Leu Single submitter ⚠
p.Arg329Lys Single submitter ⚠
p.Arg430His Single submitter ⚠
p.Arg762Gln Single submitter ⚠
p.Arg790His Single submitter ⚠
p.Asn141Ser Single submitter ⚠
p.Asn143Ser Single submitter ⚠
p.Asn218Ser Single submitter ⚠
p.Asn301Ile Single submitter ⚠
p.Asn322Ser Single submitter ⚠
p.Asn432Ser Single submitter ⚠
p.Asn568Lys Single submitter ⚠
p.Asn639Lys Single submitter ⚠
p.Asp162Gly Single submitter ⚠
p.Asp200Tyr Single submitter ⚠
p.Asp300His Single submitter ⚠
p.Asp502Val Single submitter ⚠
p.Asp54Tyr Single submitter ⚠
p.Asp640Gly Single submitter ⚠
p.Asp651His Single submitter ⚠
p.Asp697Asn Single submitter ⚠
p.Asp774Glu Single submitter ⚠
p.Asp77Asn Single submitter ⚠
p.Asp832Asn Single submitter ⚠
p.Asp863Asn Single submitter ⚠
p.Asp879Asn Single submitter ⚠
p.Asp879Gly Single submitter ⚠
p.Asp885Glu Single submitter ⚠
p.Asp899Gly Single submitter ⚠
p.Asp908Asn Single submitter ⚠
p.Cys282Trp Single submitter ⚠
p.Gln132His Single submitter ⚠
p.Gln173His Single submitter ⚠
p.Gln214Arg Single submitter ⚠
p.Gln748His Single submitter ⚠
p.Glu291Gln Single submitter ⚠
p.Glu345Gly Single submitter ⚠
p.Glu407Asp Single submitter ⚠
p.Glu423Asp Single submitter ⚠
p.Glu454Ala Single submitter ⚠
p.Glu454Gly Single submitter ⚠
p.Glu852Gly Single submitter ⚠
p.Glu909Asp Single submitter ⚠
p.Gly180Glu Single submitter ⚠
p.Gly229Ala Single submitter ⚠
p.Gly321Arg Single submitter ⚠
p.Gly39Val Single submitter ⚠
p.Gly422Val Single submitter ⚠
p.Gly500Ser Single submitter ⚠
p.Gly71Asp Single submitter ⚠
p.Gly74Val Single submitter ⚠
p.Gly769Asp Single submitter ⚠
p.Gly82Arg Single submitter ⚠
p.Gly868Arg Single submitter ⚠
p.Gly918Glu Single submitter ⚠
p.Gly958Arg Single submitter ⚠
p.His148Tyr Single submitter ⚠
p.His413Tyr Single submitter ⚠
p.His791Arg Single submitter ⚠
p.His791Tyr Single submitter ⚠
p.Ile294Phe Single submitter ⚠
p.Ile442Val Single submitter ⚠
p.Ile636Thr Single submitter ⚠
p.Ile68Thr Single submitter ⚠
p.Ile997Thr Single submitter ⚠
p.Leu186Val Single submitter ⚠
p.Leu208Phe Single submitter ⚠
p.Leu253Ile Single submitter ⚠
p.Leu269Pro Single submitter ⚠
p.Leu330Arg Single submitter ⚠
p.Leu660Pro Single submitter ⚠
p.Leu8Met Single submitter ⚠
p.Leu8Val Single submitter ⚠
p.Lys1005Glu Single submitter ⚠
p.Lys1036Asn Single submitter ⚠
p.Lys1041Arg Single submitter ⚠
p.Lys138Asn Single submitter ⚠
p.Lys138Glu Single submitter ⚠
p.Lys13Arg Single submitter ⚠
p.Lys140Glu Single submitter ⚠
p.Lys163Arg Single submitter ⚠
p.Lys182Arg Single submitter ⚠
p.Lys204Met Single submitter ⚠
p.Lys412Gln Single submitter ⚠
p.Lys551Asn Single submitter ⚠
p.Lys5Glu Single submitter ⚠
p.Lys691Gln Single submitter ⚠
p.Lys797Arg Single submitter ⚠
p.Lys820Gln Single submitter ⚠
p.Lys828Gln Single submitter ⚠
p.Lys861Arg Single submitter ⚠
p.Lys949Asn Single submitter ⚠
p.Lys949Glu Single submitter ⚠
p.Met248Ile Single submitter ⚠
p.Met565Thr Single submitter ⚠
p.Met644Val Single submitter ⚠
p.Met864Thr Single submitter ⚠
p.Met906Val Single submitter ⚠
p.Met999Ile Single submitter ⚠
p.Met999Leu Single submitter ⚠
p.Phe220Leu Single submitter ⚠
p.Phe289Leu Single submitter ⚠
p.Phe444Val Single submitter ⚠
p.Phe635Cys Single submitter ⚠
p.Phe699Leu Single submitter ⚠
p.Phe954Ile Single submitter ⚠
p.Pro145Ser Single submitter ⚠
p.Pro157Ser Single submitter ⚠
p.Pro179Leu Single submitter ⚠
p.Pro198Arg Single submitter ⚠
p.Pro414Ser Single submitter ⚠
p.Pro600Ser Single submitter ⚠
p.Pro766Leu Single submitter ⚠
p.Pro7His Single submitter ⚠
p.Ser193Tyr Single submitter ⚠
p.Ser203Tyr Single submitter ⚠
p.Ser308Ile Single submitter ⚠
p.Ser434Ile Single submitter ⚠
p.Ser523Gly Single submitter ⚠
p.Ser700Gly Single submitter ⚠
p.Ser929Thr Single submitter ⚠
p.Thr207Ile Single submitter ⚠
p.Thr207Ser Single submitter ⚠
p.Thr268Ile Single submitter ⚠
p.Thr33Ser Single submitter ⚠
p.Thr352Pro Single submitter ⚠
p.Thr546Ile Single submitter ⚠
p.Thr60Ile Single submitter ⚠
p.Thr669Asn Single submitter ⚠
p.Thr673Asn Single submitter ⚠
p.Thr773Arg Single submitter ⚠
p.Thr850Ala Single submitter ⚠
p.Thr943Ile Single submitter ⚠
p.Trp234Cys Single submitter ⚠
p.Tyr549Cys Single submitter ⚠
p.Tyr739Cys Single submitter ⚠
p.Tyr818Asp Single submitter ⚠
p.Val202Leu Single submitter ⚠
p.Val273Gly Single submitter ⚠
p.Val273Ile Single submitter ⚠
p.Val368Leu Single submitter ⚠
p.Val368Met Single submitter ⚠
p.Val420Leu Single submitter ⚠
p.Val4Leu Single submitter ⚠
p.Val514Met Single submitter ⚠
p.Val579Met Single submitter ⚠
p.Val721Ala Single submitter ⚠
p.Val727Met Single submitter ⚠
p.Val809Met Single submitter ⚠
p.Tyr213Ter No assertion criteria