CEND1 — 41 ClinVar variants
All ClinVar germline CEND1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 38 flagged for review →
3 Likely benign · 38 Uncertain significance
Full CEND1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 38
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CEND1 p.Ala101Gly Uncertain significance Single submitter
- CEND1 p.Ala101Thr Uncertain significance Single submitter
- CEND1 p.Ala101Val Uncertain significance Single submitter
- CEND1 p.Ala106Ser Uncertain significance Single submitter
- CEND1 p.Ala54Ser Uncertain significance Single submitter
- CEND1 p.Ala70Pro Uncertain significance Single submitter
- CEND1 p.Ala81Val Uncertain significance Single submitter
- CEND1 p.Ala90Thr Uncertain significance Single submitter
- CEND1 p.Asp31Asn Uncertain significance Single submitter
- CEND1 p.Asp68Asn Uncertain significance Single submitter
- CEND1 p.Asp89Asn Uncertain significance Single submitter
- CEND1 p.Asp99Glu Uncertain significance Single submitter
- CEND1 p.Glu23Lys Uncertain significance Single submitter
- CEND1 p.Glu47Lys Uncertain significance Single submitter
- CEND1 p.Gly100Arg Uncertain significance Single submitter
- CEND1 p.Gly109Glu Uncertain significance Single submitter
- CEND1 p.Gly115Ser Uncertain significance Single submitter
- CEND1 p.Gly129Arg Uncertain significance Single submitter
- CEND1 p.Gly32Arg Uncertain significance Single submitter
- CEND1 p.Gly98Glu Uncertain significance Single submitter
- CEND1 p.Lys42Glu Uncertain significance Single submitter
- CEND1 p.Pro27Ser Uncertain significance Single submitter
- CEND1 p.Pro39Ser Uncertain significance Single submitter
- CEND1 p.Pro52Thr Uncertain significance Single submitter
- CEND1 p.Ser86Arg Uncertain significance Single submitter
- CEND1 p.Val127Leu Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- CEND1 p.Ala54Asp Uncertain significance Single submitter
- CEND1 p.Arg147Gln Uncertain significance Single submitter
- CEND1 p.Arg147Trp Uncertain significance Single submitter
- CEND1 p.Asp14Asn Uncertain significance Single submitter
- CEND1 p.Asp14His Uncertain significance Single submitter
- CEND1 p.Gly130Ser Uncertain significance Single submitter
- CEND1 p.Lys12Arg Uncertain significance Single submitter
- CEND1 p.Lys16Glu Uncertain significance Single submitter
- CEND1 p.Pro28Leu Uncertain significance Single submitter
- CEND1 p.Pro51Leu Uncertain significance Single submitter
- CEND1 p.Thr57Met Uncertain significance Single submitter
- CEND1 p.Thr91Asn Uncertain significance Single submitter
All CEND1 variants
Likely benign 3
- p.Arg114Gln Single submitter
- p.Cys119Phe Single submitter
- p.Phe122Leu Single submitter
Uncertain significance 38
- p.Ala101Gly Single submitter ⚠
- p.Ala101Thr Single submitter ⚠
- p.Ala101Val Single submitter ⚠
- p.Ala106Ser Single submitter ⚠
- p.Ala54Asp Single submitter ⚠
- p.Ala54Ser Single submitter ⚠
- p.Ala70Pro Single submitter ⚠
- p.Ala81Val Single submitter ⚠
- p.Ala90Thr Single submitter ⚠
- p.Arg147Gln Single submitter ⚠
- p.Arg147Trp Single submitter ⚠
- p.Asp14Asn Single submitter ⚠
- p.Asp14His Single submitter ⚠
- p.Asp31Asn Single submitter ⚠
- p.Asp68Asn Single submitter ⚠
- p.Asp89Asn Single submitter ⚠
- p.Asp99Glu Single submitter ⚠
- p.Glu23Lys Single submitter ⚠
- p.Glu47Lys Single submitter ⚠
- p.Gly100Arg Single submitter ⚠
- p.Gly109Glu Single submitter ⚠
- p.Gly115Ser Single submitter ⚠
- p.Gly129Arg Single submitter ⚠
- p.Gly130Ser Single submitter ⚠
- p.Gly32Arg Single submitter ⚠
- p.Gly98Glu Single submitter ⚠
- p.Lys12Arg Single submitter ⚠
- p.Lys16Glu Single submitter ⚠
- p.Lys42Glu Single submitter ⚠
- p.Pro27Ser Single submitter ⚠
- p.Pro28Leu Single submitter ⚠
- p.Pro39Ser Single submitter ⚠
- p.Pro51Leu Single submitter ⚠
- p.Pro52Thr Single submitter ⚠
- p.Ser86Arg Single submitter ⚠
- p.Thr57Met Single submitter ⚠
- p.Thr91Asn Single submitter ⚠
- p.Val127Leu Single submitter ⚠