CENPB — 55 ClinVar variants
All ClinVar germline CENPB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
1 Likely benign · 54 Uncertain significance
Full CENPB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CENPB p.Ala174Pro Uncertain significance Single submitter
- CENPB p.Ala231Thr Uncertain significance Single submitter
- CENPB p.Ala301Pro Uncertain significance Single submitter
- CENPB p.Ala345Thr Uncertain significance Single submitter
- CENPB p.Arg175Gln Uncertain significance Single submitter
- CENPB p.Arg298Gly Uncertain significance Single submitter
- CENPB p.Arg338Gly Uncertain significance Single submitter
- CENPB p.Arg566His Uncertain significance Single submitter
- CENPB p.Arg588Gly Uncertain significance Single submitter
- CENPB p.Asp25Asn Uncertain significance Single submitter
- CENPB p.Asp282Tyr Uncertain significance Single submitter
- CENPB p.Asp353Gly Uncertain significance Single submitter
- CENPB p.Asp532Glu Uncertain significance Single submitter
- CENPB p.Gln332Lys Uncertain significance Single submitter
- CENPB p.Gln493His Uncertain significance Single submitter
- CENPB p.Gly166Asp Uncertain significance Single submitter
- CENPB p.Gly253Arg Uncertain significance Single submitter
- CENPB p.Gly297Ser Uncertain significance Single submitter
- CENPB p.Gly422Glu Uncertain significance Single submitter
- CENPB p.Gly437Val Uncertain significance Single submitter
- CENPB p.Gly439Glu Uncertain significance Single submitter
- CENPB p.Gly452Val Uncertain significance Single submitter
- CENPB p.Gly488Arg Uncertain significance Single submitter
- CENPB p.Gly536Ser Uncertain significance Single submitter
- CENPB p.His336Asp Uncertain significance Single submitter
- CENPB p.Lys276Asn Uncertain significance Single submitter
- CENPB p.Pro157Ala Uncertain significance Single submitter
- CENPB p.Pro179Ser Uncertain significance Single submitter
- CENPB p.Pro218Leu Uncertain significance Single submitter
- CENPB p.Ser181Ala Uncertain significance Single submitter
- CENPB p.Ser456Asn Uncertain significance Single submitter
- CENPB p.Val322Leu Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- CENPB p.Ala381Val Uncertain significance Single submitter
- CENPB p.Arg219Cys Uncertain significance Single submitter
- CENPB p.Arg588Ser Uncertain significance Single submitter
- CENPB p.Asn264Lys Uncertain significance Single submitter
- CENPB p.Asn264Ser Uncertain significance Single submitter
- CENPB p.Glu21Gln Uncertain significance Single submitter
- CENPB p.Glu412Lys Uncertain significance Single submitter
- CENPB p.Glu419Val Uncertain significance Single submitter
- CENPB p.Glu425Asp Uncertain significance Single submitter
- CENPB p.Glu425Lys Uncertain significance Single submitter
- CENPB p.Glu447Asp Uncertain significance Single submitter
- CENPB p.Gly320Ala Uncertain significance Single submitter
- CENPB p.Gly420Asp Uncertain significance Single submitter
- CENPB p.Gly429Val Uncertain significance Single submitter
- CENPB p.Gly436Arg Uncertain significance Single submitter
- CENPB p.Leu572Phe Uncertain significance Single submitter
- CENPB p.Phe316Ser Uncertain significance Single submitter
- CENPB p.Phe316Val Uncertain significance Single submitter
- CENPB p.Pro157Leu Uncertain significance Single submitter
- CENPB p.Pro205Thr Uncertain significance Single submitter
- CENPB p.Ser193Gly Uncertain significance Single submitter
- CENPB p.Thr271Ile Uncertain significance Single submitter
All CENPB variants
Likely benign 1
- p.Ala492= Single submitter
Uncertain significance 54
- p.Ala174Pro Single submitter ⚠
- p.Ala231Thr Single submitter ⚠
- p.Ala301Pro Single submitter ⚠
- p.Ala345Thr Single submitter ⚠
- p.Ala381Val Single submitter ⚠
- p.Arg175Gln Single submitter ⚠
- p.Arg219Cys Single submitter ⚠
- p.Arg298Gly Single submitter ⚠
- p.Arg338Gly Single submitter ⚠
- p.Arg566His Single submitter ⚠
- p.Arg588Gly Single submitter ⚠
- p.Arg588Ser Single submitter ⚠
- p.Asn264Lys Single submitter ⚠
- p.Asn264Ser Single submitter ⚠
- p.Asp25Asn Single submitter ⚠
- p.Asp282Tyr Single submitter ⚠
- p.Asp353Gly Single submitter ⚠
- p.Asp532Glu Single submitter ⚠
- p.Gln332Lys Single submitter ⚠
- p.Gln493His Single submitter ⚠
- p.Glu21Gln Single submitter ⚠
- p.Glu412Lys Single submitter ⚠
- p.Glu419Val Single submitter ⚠
- p.Glu425Asp Single submitter ⚠
- p.Glu425Lys Single submitter ⚠
- p.Glu447Asp Single submitter ⚠
- p.Gly166Asp Single submitter ⚠
- p.Gly253Arg Single submitter ⚠
- p.Gly297Ser Single submitter ⚠
- p.Gly320Ala Single submitter ⚠
- p.Gly420Asp Single submitter ⚠
- p.Gly422Glu Single submitter ⚠
- p.Gly429Val Single submitter ⚠
- p.Gly436Arg Single submitter ⚠
- p.Gly437Val Single submitter ⚠
- p.Gly439Glu Single submitter ⚠
- p.Gly452Val Single submitter ⚠
- p.Gly488Arg Single submitter ⚠
- p.Gly536Ser Single submitter ⚠
- p.His336Asp Single submitter ⚠
- p.Leu572Phe Single submitter ⚠
- p.Lys276Asn Single submitter ⚠
- p.Phe316Ser Single submitter ⚠
- p.Phe316Val Single submitter ⚠
- p.Pro157Ala Single submitter ⚠
- p.Pro157Leu Single submitter ⚠
- p.Pro179Ser Single submitter ⚠
- p.Pro205Thr Single submitter ⚠
- p.Pro218Leu Single submitter ⚠
- p.Ser181Ala Single submitter ⚠
- p.Ser193Gly Single submitter ⚠
- p.Ser456Asn Single submitter ⚠
- p.Thr271Ile Single submitter ⚠
- p.Val322Leu Single submitter ⚠