CENPM — 27 ClinVar variants
All ClinVar germline CENPM variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
27 Uncertain significance
Full CENPM gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CENPM p.Ala16Asp Uncertain significance Single submitter
- CENPM p.Arg145His Uncertain significance Single submitter
- CENPM p.Arg148His Uncertain significance Single submitter
- CENPM p.Asn14Ser Uncertain significance Single submitter
- CENPM p.Cys131Ser Uncertain significance Single submitter
- CENPM p.Cys40Ser Uncertain significance Single submitter
- CENPM p.Gln30Arg Uncertain significance Single submitter
- CENPM p.His122Asp Uncertain significance Single submitter
- CENPM p.His156Tyr Uncertain significance Single submitter
- CENPM p.Leu180Pro Uncertain significance Single submitter
- CENPM p.Leu36His Uncertain significance Single submitter
- CENPM p.Pro11Arg Uncertain significance Single submitter
- CENPM p.Pro6Ser Uncertain significance Single submitter
- CENPM p.Ser171Gly Uncertain significance Single submitter
- CENPM p.Ser34Thr Uncertain significance Single submitter
- CENPM p.Val149Leu Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- CENPM p.Arg106Trp Uncertain significance Single submitter
- CENPM p.Arg114Trp Uncertain significance Single submitter
- CENPM p.Arg86Pro Uncertain significance Single submitter
- CENPM p.Cys131Tyr Uncertain significance Single submitter
- CENPM p.Cys40Arg Uncertain significance Single submitter
- CENPM p.Glu134Lys Uncertain significance Single submitter
- CENPM p.Gly137Cys Uncertain significance Single submitter
- CENPM p.Gly159Ser Uncertain significance Single submitter
- CENPM p.Leu72Val Uncertain significance Single submitter
- CENPM p.Phe92Cys Uncertain significance Single submitter
- CENPM p.Val117Met Uncertain significance Single submitter
All CENPM variants
Uncertain significance 27
- p.Ala16Asp Single submitter ⚠
- p.Arg106Trp Single submitter ⚠
- p.Arg114Trp Single submitter ⚠
- p.Arg145His Single submitter ⚠
- p.Arg148His Single submitter ⚠
- p.Arg86Pro Single submitter ⚠
- p.Asn14Ser Single submitter ⚠
- p.Cys131Ser Single submitter ⚠
- p.Cys131Tyr Single submitter ⚠
- p.Cys40Arg Single submitter ⚠
- p.Cys40Ser Single submitter ⚠
- p.Gln30Arg Single submitter ⚠
- p.Glu134Lys Single submitter ⚠
- p.Gly137Cys Single submitter ⚠
- p.Gly159Ser Single submitter ⚠
- p.His122Asp Single submitter ⚠
- p.His156Tyr Single submitter ⚠
- p.Leu180Pro Single submitter ⚠
- p.Leu36His Single submitter ⚠
- p.Leu72Val Single submitter ⚠
- p.Phe92Cys Single submitter ⚠
- p.Pro11Arg Single submitter ⚠
- p.Pro6Ser Single submitter ⚠
- p.Ser171Gly Single submitter ⚠
- p.Ser34Thr Single submitter ⚠
- p.Val117Met Single submitter ⚠
- p.Val149Leu Single submitter ⚠