CENPO — 38 ClinVar variants
All ClinVar germline CENPO variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
7 Likely benign · 31 Uncertain significance
Full CENPO gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CENPO p.Ala194Val Uncertain significance Single submitter
- CENPO p.Arg196Gln Uncertain significance Single submitter
- CENPO p.Arg57Cys Uncertain significance Single submitter
- CENPO p.Arg67Gln Uncertain significance Single submitter
- CENPO p.Asp249Tyr Uncertain significance Single submitter
- CENPO p.Gln229His Uncertain significance Single submitter
- CENPO p.Gln3Glu Uncertain significance Single submitter
- CENPO p.Glu292Asp Uncertain significance Single submitter
- CENPO p.His53Asn Uncertain significance Single submitter
- CENPO p.Leu142Ile Uncertain significance Single submitter
- CENPO p.Leu7Ser Uncertain significance Single submitter
- CENPO p.Phe231Ser Uncertain significance Single submitter
- CENPO p.Ser119Arg Uncertain significance Single submitter
- CENPO p.Ser31Thr Uncertain significance Single submitter
- CENPO p.Thr248Ser Uncertain significance Single submitter
- CENPO p.Trp264Ser Uncertain significance Single submitter
- CENPO p.Val257Leu Uncertain significance Single submitter
- CENPO p.Val41Met Uncertain significance Single submitter
- CENPO p.Val65Met Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- CENPO p.Ala285Val Uncertain significance Single submitter
- CENPO p.Arg149Trp Uncertain significance Single submitter
- CENPO p.Arg32Cys Uncertain significance Single submitter
- CENPO p.Arg57His Likely benign Single submitter
- CENPO p.Glu266Val Uncertain significance Single submitter
- CENPO p.Glu272Lys Uncertain significance Single submitter
- CENPO p.Leu148Phe Uncertain significance Single submitter
- CENPO p.Leu55Arg Uncertain significance Single submitter
- CENPO p.Pro279Arg Uncertain significance Single submitter
- CENPO p.Ser119Ile Uncertain significance Single submitter
- CENPO p.Thr128Pro Uncertain significance Single submitter
- CENPO p.Thr248Ile Uncertain significance Single submitter
- CENPO p.Val252Met Uncertain significance Single submitter
All CENPO variants
Likely benign 7
- p.Arg57His Single submitter ⚠
- p.Asn89Ser Single submitter
- p.Glu61Lys Single submitter
- p.Phe178Cys Single submitter
- p.Pro232Leu Single submitter
- p.Ser40Arg Single submitter
- p.Ser72Arg Single submitter
Uncertain significance 31
- p.Ala194Val Single submitter ⚠
- p.Ala285Val Single submitter ⚠
- p.Arg149Trp Single submitter ⚠
- p.Arg196Gln Single submitter ⚠
- p.Arg32Cys Single submitter ⚠
- p.Arg57Cys Single submitter ⚠
- p.Arg67Gln Single submitter ⚠
- p.Asp249Tyr Single submitter ⚠
- p.Gln229His Single submitter ⚠
- p.Gln3Glu Single submitter ⚠
- p.Glu266Val Single submitter ⚠
- p.Glu272Lys Single submitter ⚠
- p.Glu292Asp Single submitter ⚠
- p.His53Asn Single submitter ⚠
- p.Leu142Ile Single submitter ⚠
- p.Leu148Phe Single submitter ⚠
- p.Leu55Arg Single submitter ⚠
- p.Leu7Ser Single submitter ⚠
- p.Phe231Ser Single submitter ⚠
- p.Pro279Arg Single submitter ⚠
- p.Ser119Arg Single submitter ⚠
- p.Ser119Ile Single submitter ⚠
- p.Ser31Thr Single submitter ⚠
- p.Thr128Pro Single submitter ⚠
- p.Thr248Ile Single submitter ⚠
- p.Thr248Ser Single submitter ⚠
- p.Trp264Ser Single submitter ⚠
- p.Val252Met Single submitter ⚠
- p.Val257Leu Single submitter ⚠
- p.Val41Met Single submitter ⚠
- p.Val65Met Single submitter ⚠