CEP295 — 431 ClinVar variants
All ClinVar germline CEP295 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 380 flagged for review →
4 Pathogenic · 2 Likely pathogenic · 20 Benign · 31 Likely benign · 374 Uncertain significance
Full CEP295 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 380
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 1
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
-
CEP295 p.Pro562Leu
Pathogenic
No assertion criteria
Seckel syndrome 11
Predictors lean, ClinVar uncertain 230
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 230
- CEP295 p.Gln2146His Uncertain significance Multiple submitters
- CEP295 p.Ala1073Ser Uncertain significance Single submitter
- CEP295 p.Ala1116Val Uncertain significance Single submitter
- CEP295 p.Ala1372Val Uncertain significance Single submitter
- CEP295 p.Ala1605Val Uncertain significance Single submitter
- CEP295 p.Ala2447Asp Uncertain significance Single submitter
- CEP295 p.Ala2464Pro Uncertain significance Single submitter
- CEP295 p.Ala355Gly Uncertain significance Single submitter
- CEP295 p.Ala488Val Uncertain significance Single submitter
- CEP295 p.Ala677Thr Uncertain significance Single submitter
- CEP295 p.Ala695Pro Uncertain significance Single submitter
- CEP295 p.Arg1174Ser Uncertain significance Single submitter
- CEP295 p.Arg117Lys Uncertain significance Single submitter
- CEP295 p.Arg1520Gln Uncertain significance Single submitter
- CEP295 p.Arg1878Gln Uncertain significance Single submitter
- CEP295 p.Arg2020Gln Uncertain significance Single submitter
- CEP295 p.Arg2102Gly Uncertain significance Single submitter
- CEP295 p.Arg2326Thr Uncertain significance Single submitter
- CEP295 p.Arg243Gln Uncertain significance Single submitter
- CEP295 p.Arg2462Thr Uncertain significance Single submitter
- CEP295 p.Arg2470His Uncertain significance Single submitter
- CEP295 p.Arg2556Ser Uncertain significance Single submitter
- CEP295 p.Arg293Cys Uncertain significance Single submitter
- CEP295 p.Arg293His Uncertain significance Single submitter
- CEP295 p.Arg302Lys Uncertain significance Single submitter
- CEP295 p.Arg395Gln Uncertain significance Single submitter
- CEP295 p.Arg650Lys Uncertain significance Single submitter
- CEP295 p.Arg694Ser Uncertain significance Single submitter
- CEP295 p.Arg936Cys Uncertain significance Single submitter
- CEP295 p.Asn103Ser Uncertain significance Single submitter
- CEP295 p.Asn1572Ser Uncertain significance Single submitter
- CEP295 p.Asn1627Ser Uncertain significance Single submitter
- CEP295 p.Asn1676Lys Uncertain significance Single submitter
- CEP295 p.Asn1684Ser Uncertain significance Single submitter
- CEP295 p.Asn16Asp Uncertain significance Single submitter
- CEP295 p.Asn1789Ser Uncertain significance Single submitter
- CEP295 p.Asn2140Lys Uncertain significance Single submitter
- CEP295 p.Asn2313His Uncertain significance Single submitter
- CEP295 p.Asn2350Ser Uncertain significance Single submitter
- CEP295 p.Asn580Thr Uncertain significance Single submitter
- CEP295 p.Asp1265Glu Uncertain significance Single submitter
- CEP295 p.Asp1824Val Uncertain significance Single submitter
- CEP295 p.Asp1911Asn Uncertain significance Single submitter
- CEP295 p.Asp2100Ala Uncertain significance Single submitter
- CEP295 p.Asp2542Gly Uncertain significance Single submitter
- CEP295 p.Asp344Glu Uncertain significance Single submitter
- CEP295 p.Asp729Tyr Uncertain significance Single submitter
- CEP295 p.Asp962Asn Uncertain significance Single submitter
- CEP295 p.Asp983Gly Uncertain significance Single submitter
- CEP295 p.Gln1184Pro Uncertain significance Single submitter
- CEP295 p.Gln1629Glu Uncertain significance Single submitter
- CEP295 p.Gln1675Arg Uncertain significance Single submitter
- CEP295 p.Gln1771Arg Uncertain significance Single submitter
- CEP295 p.Gln2176Arg Uncertain significance Single submitter
- CEP295 p.Gln2176His Uncertain significance Single submitter
- CEP295 p.Gln231Arg Uncertain significance Single submitter
- CEP295 p.Gln2343Glu Uncertain significance Single submitter
- CEP295 p.Gln2434Lys Uncertain significance Single submitter
- CEP295 p.Gln2480Arg Uncertain significance Single submitter
- CEP295 p.Gln2496Glu Uncertain significance Single submitter
- CEP295 p.Gln2560Lys Uncertain significance Single submitter
- CEP295 p.Gln2574Glu Uncertain significance Single submitter
- CEP295 p.Gln509Glu Uncertain significance Single submitter
- CEP295 p.Gln522Arg Uncertain significance Single submitter
- CEP295 p.Gln528Lys Uncertain significance Single submitter
- CEP295 p.Gln554His Uncertain significance Single submitter
- CEP295 p.Gln712Pro Uncertain significance Single submitter
- CEP295 p.Gln766Glu Uncertain significance Single submitter
- CEP295 p.Gln767Lys Uncertain significance Single submitter
- CEP295 p.Gln870Arg Uncertain significance Single submitter
- CEP295 p.Gln99Glu Uncertain significance Single submitter
- CEP295 p.Glu1460Lys Uncertain significance Single submitter
- CEP295 p.Glu1639Gln Uncertain significance Single submitter
- CEP295 p.Glu1819Lys Uncertain significance Single submitter
- CEP295 p.Glu1872Val Uncertain significance Single submitter
- CEP295 p.Glu1937Gly Uncertain significance Single submitter
- CEP295 p.Glu1987Lys Uncertain significance Single submitter
- CEP295 p.Glu2178Lys Uncertain significance Single submitter
- CEP295 p.Glu2273Gln Uncertain significance Single submitter
- CEP295 p.Glu2283Asp Uncertain significance Single submitter
- CEP295 p.Glu238Gln Uncertain significance Single submitter
- CEP295 p.Glu2426Asp Uncertain significance Single submitter
- CEP295 p.Glu2426Lys Uncertain significance Single submitter
- CEP295 p.Glu364Asp Uncertain significance Single submitter
- CEP295 p.Glu708Lys Uncertain significance Single submitter
- CEP295 p.Glu717Lys Uncertain significance Single submitter
- CEP295 p.Gly1090Val Uncertain significance Single submitter
- CEP295 p.Gly1135Ser Uncertain significance Single submitter
- CEP295 p.Gly1287Ser Uncertain significance Single submitter
- CEP295 p.Gly1910Asp Uncertain significance Single submitter
- CEP295 p.Gly2288Arg Uncertain significance Single submitter
- CEP295 p.Gly2288Glu Uncertain significance Single submitter
- CEP295 p.Gly430Arg Uncertain significance Single submitter
- CEP295 p.His1021Arg Uncertain significance Single submitter
- CEP295 p.His1075Leu Uncertain significance Single submitter
- CEP295 p.His1640Tyr Uncertain significance Single submitter
- CEP295 p.His1722Arg Uncertain significance Single submitter
- CEP295 p.His1746Leu Uncertain significance Single submitter
- CEP295 p.His1894Arg Uncertain significance Single submitter
- CEP295 p.His1927Gln Uncertain significance Single submitter
- CEP295 p.His2027Arg Uncertain significance Single submitter
- CEP295 p.His2041Asp Uncertain significance Single submitter
- CEP295 p.His2069Gln Uncertain significance Single submitter
- CEP295 p.His2270Arg Uncertain significance Single submitter
- CEP295 p.His2270Tyr Uncertain significance Single submitter
- CEP295 p.His2393Leu Uncertain significance Single submitter
- CEP295 p.His644Leu Uncertain significance Single submitter
- CEP295 p.His673Arg Uncertain significance Single submitter
- CEP295 p.His681Arg Uncertain significance Single submitter
- CEP295 p.His709Tyr Uncertain significance Single submitter
- CEP295 p.Ile1165Val Uncertain significance Single submitter
- CEP295 p.Ile1387Met Uncertain significance Single submitter
- CEP295 p.Ile1422Val Uncertain significance Single submitter
- CEP295 p.Ile1473Thr Uncertain significance Single submitter
- CEP295 p.Ile1522Leu Uncertain significance Single submitter
- CEP295 p.Ile183Asn Uncertain significance Single submitter
- CEP295 p.Ile1870Thr Uncertain significance Single submitter
- CEP295 p.Ile2052Val Uncertain significance Single submitter
- CEP295 p.Ile2097Leu Uncertain significance Single submitter
- CEP295 p.Ile2218Val Uncertain significance Single submitter
- CEP295 p.Ile2225Asn Uncertain significance Single submitter
- CEP295 p.Ile2458Thr Uncertain significance Single submitter
- CEP295 p.Ile2513Thr Uncertain significance Single submitter
- CEP295 p.Ile381Phe Uncertain significance Single submitter
- CEP295 p.Ile44Val Uncertain significance Single submitter
- CEP295 p.Ile48Met Uncertain significance Single submitter
- CEP295 p.Ile628Thr Uncertain significance Single submitter
- CEP295 p.Ile641Thr Uncertain significance Single submitter
- CEP295 p.Ile664Met Uncertain significance Single submitter
- CEP295 p.Ile807Val Uncertain significance Single submitter
- CEP295 p.Leu174Val Uncertain significance Single submitter
- CEP295 p.Leu1969Pro Uncertain significance Single submitter
- CEP295 p.Leu264Ile Uncertain significance Single submitter
- CEP295 p.Leu286Val Uncertain significance Single submitter
- CEP295 p.Leu345Phe Uncertain significance Single submitter
- CEP295 p.Leu768Ser Uncertain significance Single submitter
- CEP295 p.Leu82Ser Uncertain significance Single submitter
- CEP295 p.Lys1066Glu Uncertain significance Single submitter
- CEP295 p.Lys1180Thr Uncertain significance Single submitter
- CEP295 p.Lys1322Thr Uncertain significance Single submitter
- CEP295 p.Lys1570Glu Uncertain significance Single submitter
- CEP295 p.Lys1666Arg Uncertain significance Single submitter
- CEP295 p.Lys1730Asn Uncertain significance Single submitter
- CEP295 p.Lys2122Glu Uncertain significance Single submitter
- CEP295 p.Lys2488Glu Uncertain significance Single submitter
- CEP295 p.Lys2504Ile Uncertain significance Single submitter
- CEP295 p.Lys265Glu Uncertain significance Single submitter
- CEP295 p.Lys317Asn Uncertain significance Single submitter
- CEP295 p.Lys551Arg Uncertain significance Single submitter
- CEP295 p.Lys668Arg Uncertain significance Single submitter
Predictors split 149
The independent predictors disagree with each other — read with care.
-
CEP295 p.Gln998Arg
Uncertain significance
Multiple submitters
Seckel syndrome 11
- CEP295 p.Glu1026Lys Benign Multiple submitters
- CEP295 p.Leu1459Arg Benign Multiple submitters
- CEP295 p.Ser440Phe Benign Multiple submitters
- CEP295 p.Ala1306Gly Uncertain significance Single submitter
- CEP295 p.Ala307Thr Uncertain significance Single submitter
- CEP295 p.Arg1373Trp Uncertain significance Single submitter
- CEP295 p.Arg1533Gly Uncertain significance Single submitter
- CEP295 p.Arg2020Trp Likely benign Single submitter
- CEP295 p.Arg208Trp Uncertain significance Single submitter
- CEP295 p.Arg212Cys Benign Single submitter
- CEP295 p.Arg236Trp Uncertain significance Single submitter
- CEP295 p.Arg2470Cys Uncertain significance Single submitter
- CEP295 p.Arg274His Uncertain significance Single submitter
- CEP295 p.Arg275Ser Uncertain significance Single submitter
- CEP295 p.Arg579Cys Uncertain significance Single submitter
- CEP295 p.Arg579His Uncertain significance Single submitter
- CEP295 p.Arg590Ser Uncertain significance Single submitter
- CEP295 p.Arg62Cys Uncertain significance Single submitter
- CEP295 p.Arg98Gly Uncertain significance Single submitter
- CEP295 p.Asn846Asp Uncertain significance Single submitter
- CEP295 p.Asp1692Gly Uncertain significance Single submitter
- CEP295 p.Asp962His Uncertain significance Single submitter
- CEP295 p.Gln1018Arg Uncertain significance Single submitter
- CEP295 p.Gln1218Arg Uncertain significance Single submitter
- CEP295 p.Gln1248His Uncertain significance Single submitter
- CEP295 p.Gln1554Arg Uncertain significance Single submitter
- CEP295 p.Gln1629Arg Uncertain significance Single submitter
- CEP295 p.Gln1691His Uncertain significance Single submitter
- CEP295 p.Gln246His Uncertain significance Single submitter
- CEP295 p.Gln808Glu Uncertain significance Single submitter
- CEP295 p.Gln851Arg Uncertain significance Single submitter
- CEP295 p.Gln865Glu Uncertain significance Single submitter
- CEP295 p.Gln946Arg Uncertain significance Single submitter
- CEP295 p.Gln990Arg Uncertain significance Single submitter
- CEP295 p.Glu1213Lys Uncertain significance Single submitter
- CEP295 p.Glu1313Asp Uncertain significance Single submitter
- CEP295 p.Glu1318Ala Uncertain significance Single submitter
- CEP295 p.Glu159Lys Uncertain significance Single submitter
- CEP295 p.Glu1612Lys Uncertain significance Single submitter
- CEP295 p.Glu1670Lys Uncertain significance Single submitter
- CEP295 p.Glu2162Ala Uncertain significance Single submitter
- CEP295 p.Glu2422Val Uncertain significance Single submitter
- CEP295 p.Glu2575Ala Uncertain significance Single submitter
- CEP295 p.Glu2593Asp Uncertain significance Single submitter
- CEP295 p.Glu436Gly Uncertain significance Single submitter
- CEP295 p.Glu455Ala Uncertain significance Single submitter
- CEP295 p.Glu527Asp Uncertain significance Single submitter
- CEP295 p.Glu597Ala Uncertain significance Single submitter
- CEP295 p.Glu70Gly Uncertain significance Single submitter
- CEP295 p.Glu866Gly Uncertain significance Single submitter
- CEP295 p.Gly1135Cys Uncertain significance Single submitter
- CEP295 p.Gly1309Asp Uncertain significance Single submitter
- CEP295 p.His1002Asp Uncertain significance Single submitter
- CEP295 p.His1002Tyr Uncertain significance Single submitter
- CEP295 p.His1653Asn Uncertain significance Single submitter
- CEP295 p.His1846Gln Uncertain significance Single submitter
- CEP295 p.His793Leu Uncertain significance Single submitter
- CEP295 p.His793Tyr Uncertain significance Single submitter
- CEP295 p.His977Arg Uncertain significance Single submitter
- CEP295 p.Ile1427Met Likely benign Single submitter
- CEP295 p.Ile1435Leu Uncertain significance Single submitter
- CEP295 p.Ile2070Met Uncertain significance Single submitter
- CEP295 p.Ile529Thr Uncertain significance Single submitter
- CEP295 p.Leu1029His Uncertain significance Single submitter
- CEP295 p.Leu1089Met Uncertain significance Single submitter
- CEP295 p.Leu1257Trp Uncertain significance Single submitter
- CEP295 p.Leu1303Phe Uncertain significance Single submitter
- CEP295 p.Leu1315Arg Uncertain significance Single submitter
- CEP295 p.Leu1354Val Uncertain significance Single submitter
- CEP295 p.Leu1505Ser Uncertain significance Single submitter
- CEP295 p.Leu1508Phe Uncertain significance Single submitter
- CEP295 p.Leu1531Ser Uncertain significance Single submitter
- CEP295 p.Leu1694Arg Uncertain significance Single submitter
- CEP295 p.Leu1732Pro Uncertain significance Single submitter
- CEP295 p.Leu2479Ser Uncertain significance Single submitter
- CEP295 p.Leu253Phe Uncertain significance Single submitter
- CEP295 p.Leu326Pro Uncertain significance Single submitter
- CEP295 p.Leu331Met Uncertain significance Single submitter
- CEP295 p.Leu34Ser Uncertain significance Single submitter
- CEP295 p.Leu854Ile Uncertain significance Single submitter
- CEP295 p.Leu85Pro Uncertain significance Single submitter
- CEP295 p.Leu872Phe Uncertain significance Single submitter
- CEP295 p.Leu953Phe Uncertain significance Single submitter
- CEP295 p.Leu974Phe Uncertain significance Single submitter
- CEP295 p.Lys1516Glu Uncertain significance Single submitter
- CEP295 p.Lys2485Met Uncertain significance Single submitter
- CEP295 p.Lys249Asn Uncertain significance Single submitter
- CEP295 p.Lys601Glu Uncertain significance Single submitter
- CEP295 p.Lys961Asn Uncertain significance Single submitter
- CEP295 p.Phe199Leu Uncertain significance Single submitter
- CEP295 p.Phe2172Leu Uncertain significance Single submitter
- CEP295 p.Phe387Leu Uncertain significance Single submitter
- CEP295 p.Phe682Leu Uncertain significance Single submitter
- CEP295 p.Pro1037Thr Uncertain significance Single submitter
- CEP295 p.Pro1136His Uncertain significance Single submitter
- CEP295 p.Pro1252Leu Uncertain significance Single submitter
- CEP295 p.Pro1293His Uncertain significance Single submitter
- CEP295 p.Pro1314Ala Uncertain significance Single submitter
- CEP295 p.Pro1419Arg Uncertain significance Single submitter
- CEP295 p.Pro1665Ala Uncertain significance Single submitter
- CEP295 p.Pro1681His Uncertain significance Single submitter
- CEP295 p.Pro1682Arg Uncertain significance Single submitter
- CEP295 p.Pro1685His Uncertain significance Single submitter
- CEP295 p.Pro810Arg Uncertain significance Single submitter
- CEP295 p.Pro890Leu Uncertain significance Single submitter
- CEP295 p.Pro901His Uncertain significance Single submitter
- CEP295 p.Ser1025Arg Uncertain significance Single submitter
- CEP295 p.Ser1098Asn Uncertain significance Single submitter
- CEP295 p.Ser1149Cys Uncertain significance Single submitter
- CEP295 p.Ser1151Gly Uncertain significance Single submitter
- CEP295 p.Ser1191Asn Uncertain significance Single submitter
- CEP295 p.Ser1209Phe Uncertain significance Single submitter
- CEP295 p.Ser1232Asn Uncertain significance Single submitter
- CEP295 p.Ser1274Thr Uncertain significance Single submitter
- CEP295 p.Ser1282Tyr Uncertain significance Single submitter
- CEP295 p.Ser1283Pro Uncertain significance Single submitter
- CEP295 p.Ser1305Leu Uncertain significance Single submitter
- CEP295 p.Ser1308Phe Uncertain significance Single submitter
- CEP295 p.Ser1319Thr Uncertain significance Single submitter
- CEP295 p.Ser1341Leu Uncertain significance Single submitter
- CEP295 p.Ser1430Leu Uncertain significance Single submitter
- CEP295 p.Ser1535Asn Uncertain significance Single submitter
- CEP295 p.Ser1543Phe Uncertain significance Single submitter
- CEP295 p.Ser1577Thr Uncertain significance Single submitter
- CEP295 p.Ser1635Gly Uncertain significance Single submitter
- CEP295 p.Ser1654Leu Uncertain significance Single submitter
- CEP295 p.Ser1683Thr Uncertain significance Single submitter
- CEP295 p.Ser1757Cys Uncertain significance Single submitter
- CEP295 p.Ser1829Cys Uncertain significance Single submitter
- CEP295 p.Ser2110Tyr Uncertain significance Single submitter
- CEP295 p.Ser2168Cys Uncertain significance Single submitter
- CEP295 p.Ser2264Arg Uncertain significance Single submitter
- CEP295 p.Ser2383Cys Uncertain significance Single submitter
- CEP295 p.Ser294Gly Uncertain significance Single submitter
- CEP295 p.Ser815Thr Uncertain significance Single submitter
- CEP295 p.Ser837Leu Uncertain significance Single submitter
- CEP295 p.Ser886Leu Uncertain significance Single submitter
- CEP295 p.Ser963Arg Uncertain significance Single submitter
- CEP295 p.Thr1012Arg Uncertain significance Single submitter
- CEP295 p.Thr1514Arg Uncertain significance Single submitter
- CEP295 p.Thr2124Ile Uncertain significance Single submitter
- CEP295 p.Thr2445Ile Uncertain significance Single submitter
- CEP295 p.Thr2591Arg Uncertain significance Single submitter
- CEP295 p.Thr451Arg Uncertain significance Single submitter
- CEP295 p.Thr883Lys Uncertain significance Single submitter
- CEP295 p.Thr883Met Likely benign Single submitter
- CEP295 p.Val1175Ile Uncertain significance Single submitter
- CEP295 p.Val1525Phe Uncertain significance Single submitter
All CEP295 variants
Pathogenic 4
- p.Arg1520Ter No assertion criteria Seckel syndrome 11
- p.Arg55fs No assertion criteria Seckel syndrome 11
- p.Gln544Ter No assertion criteria Seckel syndrome 11
- p.Pro562Leu No assertion criteria Seckel syndrome 11 ⚠
Likely pathogenic 2
- p.Ala2429fs Single submitter Seckel syndrome 11
- p.Glu1544fs Single submitter Seckel syndrome 11
Benign 20
- p.Gln1506= Multiple submitters
- p.Gln1728= Multiple submitters
- p.Gln80Lys Multiple submitters
- p.Glu1026Lys Multiple submitters ⚠
- p.Glu179Lys Multiple submitters
- p.Ile2505= Multiple submitters
- p.Leu1459Arg Multiple submitters ⚠
- p.Lys1594Gln Multiple submitters
- p.Phe888Ser Multiple submitters
- p.Ser440Phe Multiple submitters ⚠
- p.Ser988= Multiple submitters
- p.Thr864= Multiple submitters
- p.Thr864Ser Multiple submitters
- c.7767+3G>A Single submitter
- c.7768-10C>T Single submitter
- p.Ala1262= Single submitter
- p.Arg212Cys Single submitter ⚠
- p.Gln2208Glu Single submitter
- p.Gly1028= Single submitter
- p.Val2026Leu Single submitter
Likely benign 31
- c.625-16T>C Single submitter
- c.7767+19_7767+20del Single submitter
- p.Ala1406Thr Single submitter
- p.Ala433Val Single submitter
- p.Arg1373Gln Single submitter
- p.Arg1580His Single submitter
- p.Arg1630Thr Single submitter
- p.Arg2020Trp Single submitter ⚠
- p.Arg212His Single submitter
- p.Arg694= Single submitter
- p.Asn2101Ser Single submitter
- p.Asp1752= Single submitter
- p.Glu912= Single submitter
- p.Ile1427Met Single submitter ⚠
- p.Ile2165Thr Single submitter
- p.Ile2334Val Single submitter
- p.Ile454Val Single submitter
- p.Ile825Val Single submitter
- p.Lys1066Thr Single submitter
- p.Met1989Val Single submitter
- p.Phe995Leu Single submitter
- p.Pro1436Ser Single submitter
- p.Pro1762Arg Single submitter Seckel syndrome 11
- p.Pro2143Leu Single submitter
- p.Thr1070Ala Single submitter
- p.Thr2600= Single submitter
- p.Thr883Met Single submitter ⚠
- p.Tyr975Cys Single submitter
- p.Val567Ile Single submitter
- p.Val787Leu Single submitter
- p.Gly2531= No assertion criteria CEP295-related condition
Uncertain significance 374
Showing the top 300 by review status; the full set is in the sitemap.
- p.Gln2146His Multiple submitters ⚠
- p.Gln998Arg Multiple submitters Seckel syndrome 11 ⚠
- p.Ala1073Ser Single submitter ⚠
- p.Ala1116Val Single submitter ⚠
- p.Ala1306Gly Single submitter ⚠
- p.Ala1372Val Single submitter ⚠
- p.Ala1605Val Single submitter ⚠
- p.Ala2447Asp Single submitter ⚠
- p.Ala2464Pro Single submitter ⚠
- p.Ala307Thr Single submitter ⚠
- p.Ala355Gly Single submitter ⚠
- p.Ala488Val Single submitter ⚠
- p.Ala677Thr Single submitter ⚠
- p.Ala695Pro Single submitter ⚠
- p.Arg1174Ser Single submitter ⚠
- p.Arg117Lys Single submitter ⚠
- p.Arg1373Trp Single submitter ⚠
- p.Arg1520Gln Single submitter ⚠
- p.Arg1533Gly Single submitter ⚠
- p.Arg1878Gln Single submitter ⚠
- p.Arg2020Gln Single submitter ⚠
- p.Arg208Trp Single submitter ⚠
- p.Arg2102Gly Single submitter ⚠
- p.Arg2326Thr Single submitter ⚠
- p.Arg236Trp Single submitter ⚠
- p.Arg243Gln Single submitter ⚠
- p.Arg2462Thr Single submitter ⚠
- p.Arg2470Cys Single submitter ⚠
- p.Arg2470His Single submitter ⚠
- p.Arg2556Ser Single submitter ⚠
- p.Arg274His Single submitter ⚠
- p.Arg275Ser Single submitter ⚠
- p.Arg293Cys Single submitter ⚠
- p.Arg293His Single submitter ⚠
- p.Arg302Lys Single submitter ⚠
- p.Arg395Gln Single submitter ⚠
- p.Arg579Cys Single submitter ⚠
- p.Arg579His Single submitter ⚠
- p.Arg590Ser Single submitter ⚠
- p.Arg62Cys Single submitter ⚠
- p.Arg650Lys Single submitter ⚠
- p.Arg694Ser Single submitter ⚠
- p.Arg936Cys Single submitter ⚠
- p.Arg98Gly Single submitter ⚠
- p.Asn103Ser Single submitter ⚠
- p.Asn1572Ser Single submitter ⚠
- p.Asn1627Ser Single submitter ⚠
- p.Asn1676Lys Single submitter ⚠
- p.Asn1684Ser Single submitter ⚠
- p.Asn16Asp Single submitter ⚠
- p.Asn1789Ser Single submitter ⚠
- p.Asn2140Lys Single submitter ⚠
- p.Asn2313His Single submitter ⚠
- p.Asn2350Ser Single submitter ⚠
- p.Asn580Thr Single submitter ⚠
- p.Asn846Asp Single submitter ⚠
- p.Asp1265Glu Single submitter ⚠
- p.Asp1692Gly Single submitter ⚠
- p.Asp1824Val Single submitter ⚠
- p.Asp1911Asn Single submitter ⚠
- p.Asp2100Ala Single submitter ⚠
- p.Asp2542Gly Single submitter ⚠
- p.Asp344Glu Single submitter ⚠
- p.Asp729Tyr Single submitter ⚠
- p.Asp962Asn Single submitter ⚠
- p.Asp962His Single submitter ⚠
- p.Asp983Gly Single submitter ⚠
- p.Gln1018Arg Single submitter ⚠
- p.Gln1184Pro Single submitter ⚠
- p.Gln1218Arg Single submitter ⚠
- p.Gln1248His Single submitter ⚠
- p.Gln1554Arg Single submitter ⚠
- p.Gln1629Arg Single submitter ⚠
- p.Gln1629Glu Single submitter ⚠
- p.Gln1675Arg Single submitter ⚠
- p.Gln1691His Single submitter ⚠
- p.Gln1771Arg Single submitter ⚠
- p.Gln2176Arg Single submitter ⚠
- p.Gln2176His Single submitter ⚠
- p.Gln231Arg Single submitter ⚠
- p.Gln2343Glu Single submitter ⚠
- p.Gln2434Lys Single submitter ⚠
- p.Gln246His Single submitter ⚠
- p.Gln2480Arg Single submitter ⚠
- p.Gln2496Glu Single submitter ⚠
- p.Gln2560Lys Single submitter ⚠
- p.Gln2574Glu Single submitter ⚠
- p.Gln509Glu Single submitter ⚠
- p.Gln522Arg Single submitter ⚠
- p.Gln528Lys Single submitter ⚠
- p.Gln554His Single submitter ⚠
- p.Gln712Pro Single submitter ⚠
- p.Gln766Glu Single submitter ⚠
- p.Gln767Lys Single submitter ⚠
- p.Gln808Glu Single submitter ⚠
- p.Gln851Arg Single submitter ⚠
- p.Gln865Glu Single submitter ⚠
- p.Gln870Arg Single submitter ⚠
- p.Gln946Arg Single submitter ⚠
- p.Gln990Arg Single submitter ⚠
- p.Gln99Glu Single submitter ⚠
- p.Glu1213Lys Single submitter ⚠
- p.Glu1313Asp Single submitter ⚠
- p.Glu1318Ala Single submitter ⚠
- p.Glu1460Lys Single submitter ⚠
- p.Glu159Lys Single submitter ⚠
- p.Glu1612Lys Single submitter ⚠
- p.Glu1639Gln Single submitter ⚠
- p.Glu1670Lys Single submitter ⚠
- p.Glu1819Lys Single submitter ⚠
- p.Glu1872Val Single submitter ⚠
- p.Glu1937Gly Single submitter ⚠
- p.Glu1987Lys Single submitter ⚠
- p.Glu2162Ala Single submitter ⚠
- p.Glu2178Lys Single submitter ⚠
- p.Glu2273Gln Single submitter ⚠
- p.Glu2283Asp Single submitter ⚠
- p.Glu238Gln Single submitter ⚠
- p.Glu2422Val Single submitter ⚠
- p.Glu2426Asp Single submitter ⚠
- p.Glu2426Lys Single submitter ⚠
- p.Glu2575Ala Single submitter ⚠
- p.Glu2593Asp Single submitter ⚠
- p.Glu364Asp Single submitter ⚠
- p.Glu436Gly Single submitter ⚠
- p.Glu455Ala Single submitter ⚠
- p.Glu527Asp Single submitter ⚠
- p.Glu597Ala Single submitter ⚠
- p.Glu708Lys Single submitter ⚠
- p.Glu70Gly Single submitter ⚠
- p.Glu717Lys Single submitter ⚠
- p.Glu866Gly Single submitter ⚠
- p.Gly1090Val Single submitter ⚠
- p.Gly1135Cys Single submitter ⚠
- p.Gly1135Ser Single submitter ⚠
- p.Gly1287Ser Single submitter ⚠
- p.Gly1309Asp Single submitter ⚠
- p.Gly1910Asp Single submitter ⚠
- p.Gly2288Arg Single submitter ⚠
- p.Gly2288Glu Single submitter ⚠
- p.Gly430Arg Single submitter ⚠
- p.His1002Asp Single submitter ⚠
- p.His1002Tyr Single submitter ⚠
- p.His1021Arg Single submitter ⚠
- p.His1075Leu Single submitter ⚠
- p.His1640Tyr Single submitter ⚠
- p.His1653Asn Single submitter ⚠
- p.His1722Arg Single submitter ⚠
- p.His1746Leu Single submitter ⚠
- p.His1846Gln Single submitter ⚠
- p.His1894Arg Single submitter ⚠
- p.His1927Gln Single submitter ⚠
- p.His2027Arg Single submitter ⚠
- p.His2041Asp Single submitter ⚠
- p.His2069Gln Single submitter ⚠
- p.His2270Arg Single submitter ⚠
- p.His2270Tyr Single submitter ⚠
- p.His2393Leu Single submitter ⚠
- p.His644Leu Single submitter ⚠
- p.His673Arg Single submitter ⚠
- p.His681Arg Single submitter ⚠
- p.His709Tyr Single submitter ⚠
- p.His793Leu Single submitter ⚠
- p.His793Tyr Single submitter ⚠
- p.His977Arg Single submitter ⚠
- p.Ile1165Val Single submitter ⚠
- p.Ile1387Met Single submitter ⚠
- p.Ile1422Val Single submitter ⚠
- p.Ile1435Leu Single submitter ⚠
- p.Ile1473Thr Single submitter ⚠
- p.Ile1522Leu Single submitter ⚠
- p.Ile183Asn Single submitter ⚠
- p.Ile1870Thr Single submitter ⚠
- p.Ile2052Val Single submitter ⚠
- p.Ile2070Met Single submitter ⚠
- p.Ile2097Leu Single submitter ⚠
- p.Ile2218Val Single submitter ⚠
- p.Ile2225Asn Single submitter ⚠
- p.Ile2458Thr Single submitter ⚠
- p.Ile2513Thr Single submitter ⚠
- p.Ile381Phe Single submitter ⚠
- p.Ile44Val Single submitter ⚠
- p.Ile48Met Single submitter ⚠
- p.Ile529Thr Single submitter ⚠
- p.Ile628Thr Single submitter ⚠
- p.Ile641Thr Single submitter ⚠
- p.Ile664Met Single submitter ⚠
- p.Ile807Val Single submitter ⚠
- p.Leu1029His Single submitter ⚠
- p.Leu1089Met Single submitter ⚠
- p.Leu1257Trp Single submitter ⚠
- p.Leu1303Phe Single submitter ⚠
- p.Leu1315Arg Single submitter ⚠
- p.Leu1354Val Single submitter ⚠
- p.Leu1505Ser Single submitter ⚠
- p.Leu1508Phe Single submitter ⚠
- p.Leu1531Ser Single submitter ⚠
- p.Leu1694Arg Single submitter ⚠
- p.Leu1732Pro Single submitter ⚠
- p.Leu174Val Single submitter ⚠
- p.Leu1969Pro Single submitter ⚠
- p.Leu2479Ser Single submitter ⚠
- p.Leu253Phe Single submitter ⚠
- p.Leu264Ile Single submitter ⚠
- p.Leu286Val Single submitter ⚠
- p.Leu326Pro Single submitter ⚠
- p.Leu331Met Single submitter ⚠
- p.Leu345Phe Single submitter ⚠
- p.Leu34Ser Single submitter ⚠
- p.Leu768Ser Single submitter ⚠
- p.Leu82Ser Single submitter ⚠
- p.Leu854Ile Single submitter ⚠
- p.Leu85Pro Single submitter ⚠
- p.Leu872Phe Single submitter ⚠
- p.Leu953Phe Single submitter ⚠
- p.Leu974Phe Single submitter ⚠
- p.Lys1066Glu Single submitter ⚠
- p.Lys1180Thr Single submitter ⚠
- p.Lys1322Thr Single submitter ⚠
- p.Lys1516Glu Single submitter ⚠
- p.Lys1570Glu Single submitter ⚠
- p.Lys1666Arg Single submitter ⚠
- p.Lys1730Asn Single submitter ⚠
- p.Lys2122Glu Single submitter ⚠
- p.Lys2485Met Single submitter ⚠
- p.Lys2488Glu Single submitter ⚠
- p.Lys249Asn Single submitter ⚠
- p.Lys2504Ile Single submitter ⚠
- p.Lys265Glu Single submitter ⚠
- p.Lys317Asn Single submitter ⚠
- p.Lys551Arg Single submitter ⚠
- p.Lys601Glu Single submitter ⚠
- p.Lys668Arg Single submitter ⚠
- p.Lys724Glu Single submitter ⚠
- p.Lys961Asn Single submitter ⚠
- p.Met1603Thr Single submitter ⚠
- p.Met2330Lys Single submitter ⚠
- p.Met234Thr Single submitter ⚠
- p.Met261Val Single submitter ⚠
- p.Phe1186Ser Single submitter ⚠
- p.Phe1300Ser Single submitter ⚠
- p.Phe1697Ser Single submitter ⚠
- p.Phe199Leu Single submitter ⚠
- p.Phe2172Leu Single submitter ⚠
- p.Phe387Leu Single submitter ⚠
- p.Phe682Leu Single submitter ⚠
- p.Pro1037Thr Single submitter ⚠
- p.Pro1136His Single submitter ⚠
- p.Pro1252Leu Single submitter ⚠
- p.Pro1293His Single submitter ⚠
- p.Pro1314Ala Single submitter ⚠
- p.Pro1419Arg Single submitter ⚠
- p.Pro1419Leu Single submitter ⚠
- p.Pro1471Arg Single submitter ⚠
- p.Pro1485Leu Single submitter ⚠
- p.Pro1620Ser Single submitter ⚠
- p.Pro1659Ser Single submitter ⚠
- p.Pro1665Ala Single submitter ⚠
- p.Pro1681His Single submitter ⚠
- p.Pro1682Arg Single submitter ⚠
- p.Pro1685His Single submitter ⚠
- p.Pro170Arg Single submitter ⚠
- p.Pro171Leu Single submitter ⚠
- p.Pro172Ala Single submitter ⚠
- p.Pro2081Leu Single submitter ⚠
- p.Pro2081Thr Single submitter ⚠
- p.Pro2143Thr Single submitter ⚠
- p.Pro2357Ala Single submitter ⚠
- p.Pro283Gln Single submitter ⚠
- p.Pro496Leu Single submitter ⚠
- p.Pro562Ala Single submitter ⚠
- p.Pro638Gln Single submitter ⚠
- p.Pro638Leu Single submitter ⚠
- p.Pro810Arg Single submitter ⚠
- p.Pro890Leu Single submitter ⚠
- p.Pro901His Single submitter ⚠
- p.Ser1022Pro Single submitter ⚠
- p.Ser1025Arg Single submitter ⚠
- p.Ser1098Asn Single submitter ⚠
- p.Ser1149Cys Single submitter ⚠
- p.Ser1151Gly Single submitter ⚠
- p.Ser1191Asn Single submitter ⚠
- p.Ser1209Phe Single submitter ⚠
- p.Ser1232Asn Single submitter ⚠
- p.Ser1274Thr Single submitter ⚠
- p.Ser1282Tyr Single submitter ⚠
- p.Ser1283Pro Single submitter ⚠
- p.Ser1305Leu Single submitter ⚠
- p.Ser1308Phe Single submitter ⚠
- p.Ser1319Thr Single submitter ⚠
- p.Ser1341Leu Single submitter ⚠
- p.Ser1381Arg Single submitter ⚠
- p.Ser1430Leu Single submitter ⚠
- p.Ser1521Ala Single submitter ⚠
- p.Ser1535Asn Single submitter ⚠
- p.Ser1543Phe Single submitter ⚠
- p.Ser1571Asn Single submitter ⚠
- p.Ser1577Thr Single submitter ⚠
- p.Ser1591Gly Single submitter ⚠
- p.Ser1635Gly Single submitter ⚠