CETN3 — 15 ClinVar variants
All ClinVar germline CETN3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 15 flagged for review →
15 Uncertain significance
Full CETN3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 15
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CETN3 p.Asp111Gly Uncertain significance Single submitter
- CETN3 p.Glu138Asp Uncertain significance Single submitter
- CETN3 p.Glu145Gly Uncertain significance Single submitter
- CETN3 p.Glu35Gln Uncertain significance Single submitter
- CETN3 p.Glu76Lys Uncertain significance Single submitter
- CETN3 p.Leu57Phe Uncertain significance Single submitter
- CETN3 p.Met134Leu Uncertain significance Single submitter
- CETN3 p.Val66Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CETN3 p.Ala44Gly Uncertain significance Single submitter
- CETN3 p.Ala77Pro Uncertain significance Single submitter
- CETN3 p.Ala77Val Uncertain significance Single submitter
- CETN3 p.Asp40Asn Uncertain significance Single submitter
- CETN3 p.Ile30Val Uncertain significance Single submitter
- CETN3 p.Leu104Phe Uncertain significance Single submitter
- CETN3 p.Lys108Gln Uncertain significance Single submitter
All CETN3 variants
Uncertain significance 15
- p.Ala44Gly Single submitter ⚠
- p.Ala77Pro Single submitter ⚠
- p.Ala77Val Single submitter ⚠
- p.Asp111Gly Single submitter ⚠
- p.Asp40Asn Single submitter ⚠
- p.Glu138Asp Single submitter ⚠
- p.Glu145Gly Single submitter ⚠
- p.Glu35Gln Single submitter ⚠
- p.Glu76Lys Single submitter ⚠
- p.Ile30Val Single submitter ⚠
- p.Leu104Phe Single submitter ⚠
- p.Leu57Phe Single submitter ⚠
- p.Lys108Gln Single submitter ⚠
- p.Met134Leu Single submitter ⚠
- p.Val66Ile Single submitter ⚠