CHAC1 — 54 ClinVar variants
All ClinVar germline CHAC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 38 flagged for review →
1 Likely benign · 53 Uncertain significance
Full CHAC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 38
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CHAC1 p.Ala160Asp Uncertain significance Single submitter
- CHAC1 p.Ala193Val Uncertain significance Single submitter
- CHAC1 p.Ala204Thr Uncertain significance Single submitter
- CHAC1 p.Ala218Thr Uncertain significance Single submitter
- CHAC1 p.Ala220Val Uncertain significance Single submitter
- CHAC1 p.Asn9Asp Uncertain significance Single submitter
- CHAC1 p.Asp51Glu Uncertain significance Single submitter
- CHAC1 p.Gln100Glu Uncertain significance Single submitter
- CHAC1 p.Gln187Arg Uncertain significance Single submitter
- CHAC1 p.Gln187Lys Uncertain significance Single submitter
- CHAC1 p.Gln31His Uncertain significance Single submitter
- CHAC1 p.Glu216Lys Uncertain significance Single submitter
- CHAC1 p.Gly154Asp Uncertain significance Single submitter
- CHAC1 p.Gly154Val Uncertain significance Single submitter
- CHAC1 p.Gly28Asp Uncertain significance Single submitter
- CHAC1 p.Gly55Ser Uncertain significance Single submitter
- CHAC1 p.Gly94Val Uncertain significance Single submitter
- CHAC1 p.Lys76Glu Uncertain significance Single submitter
- CHAC1 p.Ser40Tyr Uncertain significance Single submitter
- CHAC1 p.Thr163Met Uncertain significance Single submitter
- CHAC1 p.Thr207Ala Uncertain significance Single submitter
- CHAC1 p.Tyr152His Uncertain significance Single submitter
- CHAC1 p.Tyr60His Uncertain significance Single submitter
- CHAC1 p.Val202Leu Uncertain significance Single submitter
- CHAC1 p.Val222Ala Uncertain significance Single submitter
- CHAC1 p.Val99Met Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- CHAC1 p.Ala156Val Uncertain significance Single submitter
- CHAC1 p.Ala193Thr Uncertain significance Single submitter
- CHAC1 p.Arg169Trp Uncertain significance Single submitter
- CHAC1 p.Arg181Cys Uncertain significance Single submitter
- CHAC1 p.Arg53Cys Uncertain significance Single submitter
- CHAC1 p.Asp75Asn Uncertain significance Single submitter
- CHAC1 p.Gln103His Uncertain significance Single submitter
- CHAC1 p.Glu196Lys Uncertain significance Single submitter
- CHAC1 p.Leu176Phe Uncertain significance Single submitter
- CHAC1 p.Phe128Leu Uncertain significance Single submitter
- CHAC1 p.Pro130Ser Uncertain significance Single submitter
- CHAC1 p.Ser5Cys Uncertain significance Single submitter
All CHAC1 variants
Likely benign 1
- p.Val57= Single submitter
Uncertain significance 53
- c.10G>A Single submitter
- c.8G>T Single submitter
- c.-101C>G Single submitter
- c.-101C>T Single submitter
- c.-102C>G Single submitter
- c.-15C>A Single submitter
- c.-15C>G Single submitter
- c.-32G>A Single submitter
- c.-35G>A Single submitter
- c.-81G>A Single submitter
- c.-87C>T Single submitter
- c.-8C>T Single submitter
- c.-96G>A Single submitter
- c.-96G>T Single submitter
- p.Ala156Val Single submitter ⚠
- p.Ala160Asp Single submitter ⚠
- p.Ala193Thr Single submitter ⚠
- p.Ala193Val Single submitter ⚠
- p.Ala204Thr Single submitter ⚠
- p.Ala218Thr Single submitter ⚠
- p.Ala220Val Single submitter ⚠
- p.Arg169Trp Single submitter ⚠
- p.Arg181Cys Single submitter ⚠
- p.Arg53Cys Single submitter ⚠
- p.Asn9Asp Single submitter ⚠
- p.Asp51Glu Single submitter ⚠
- p.Asp75Asn Single submitter ⚠
- p.Gln100Glu Single submitter ⚠
- p.Gln103His Single submitter ⚠
- p.Gln187Arg Single submitter ⚠
- p.Gln187Lys Single submitter ⚠
- p.Gln31His Single submitter ⚠
- p.Glu196Lys Single submitter ⚠
- p.Glu216Lys Single submitter ⚠
- p.Gly154Asp Single submitter ⚠
- p.Gly154Val Single submitter ⚠
- p.Gly28Asp Single submitter ⚠
- p.Gly55Ser Single submitter ⚠
- p.Gly94Val Single submitter ⚠
- p.Leu176Phe Single submitter ⚠
- p.Lys76Glu Single submitter ⚠
- p.Phe128Leu Single submitter ⚠
- p.Pro130Ser Single submitter ⚠
- p.Ser40Tyr Single submitter ⚠
- p.Ser5Cys Single submitter ⚠
- p.Thr163Met Single submitter ⚠
- p.Thr207Ala Single submitter ⚠
- p.Tyr152His Single submitter ⚠
- p.Tyr60His Single submitter ⚠
- p.Val202Leu Single submitter ⚠
- p.Val222Ala Single submitter ⚠
- p.Val99Met Single submitter ⚠
- p.Trp93Ter No assertion criteria prostate cancer