CHRM5 — 59 ClinVar variants
All ClinVar germline CHRM5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 51 flagged for review →
2 Benign · 3 Likely benign · 54 Uncertain significance
Full CHRM5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 51
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CHRM5 p.Ala269Pro Uncertain significance Single submitter
- CHRM5 p.Ala339Val Uncertain significance Single submitter
- CHRM5 p.Ala366Thr Uncertain significance Single submitter
- CHRM5 p.Ala441Val Uncertain significance Single submitter
- CHRM5 p.Ala9Gly Uncertain significance Single submitter
- CHRM5 p.Arg128His Uncertain significance Single submitter
- CHRM5 p.Arg139Leu Uncertain significance Single submitter
- CHRM5 p.Arg142Cys Uncertain significance Single submitter
- CHRM5 p.Arg142His Uncertain significance Single submitter
- CHRM5 p.Arg218Gln Uncertain significance Single submitter
- CHRM5 p.Arg24Cys Uncertain significance Single submitter
- CHRM5 p.Arg255Leu Uncertain significance Single submitter
- CHRM5 p.Arg26Lys Uncertain significance Single submitter
- CHRM5 p.Arg275Cys Uncertain significance Single submitter
- CHRM5 p.Arg275His Uncertain significance Single submitter
- CHRM5 p.Arg500Lys Uncertain significance Single submitter
- CHRM5 p.Arg513Gln Uncertain significance Single submitter
- CHRM5 p.Arg95His Uncertain significance Single submitter
- CHRM5 p.Asn293Ser Uncertain significance Single submitter
- CHRM5 p.Asp318Tyr Uncertain significance Single submitter
- CHRM5 p.Asp357Asn Uncertain significance Single submitter
- CHRM5 p.Asp469Glu Uncertain significance Single submitter
- CHRM5 p.Gln286Glu Uncertain significance Single submitter
- CHRM5 p.Glu310Ala Uncertain significance Single submitter
- CHRM5 p.Glu343Val Uncertain significance Single submitter
- CHRM5 p.Gly196Arg Uncertain significance Single submitter
- CHRM5 p.Gly389Arg Uncertain significance Single submitter
- CHRM5 p.Gly527Arg Uncertain significance Single submitter
- CHRM5 p.Ile79Thr Uncertain significance Single submitter
- CHRM5 p.Leu167Phe Uncertain significance Single submitter
- CHRM5 p.Leu444Val Uncertain significance Single submitter
- CHRM5 p.Lys353Arg Uncertain significance Single submitter
- CHRM5 p.Lys522Arg Uncertain significance Single submitter
- CHRM5 p.Met93Val Uncertain significance Single submitter
- CHRM5 p.Phe337Cys Uncertain significance Single submitter
- CHRM5 p.Pro408Leu Uncertain significance Single submitter
- CHRM5 p.Pro422Arg Uncertain significance Single submitter
- CHRM5 p.Pro457Leu Uncertain significance Single submitter
- CHRM5 p.Ser125Gly Uncertain significance Single submitter
- CHRM5 p.Ser285Phe Uncertain significance Single submitter
- CHRM5 p.Ser59Asn Uncertain significance Single submitter
- CHRM5 p.Thr10Ala Uncertain significance Single submitter
- CHRM5 p.Thr301Ile Uncertain significance Single submitter
- CHRM5 p.Val347Glu Uncertain significance Single submitter
- CHRM5 p.Val377Gly Uncertain significance Single submitter
- CHRM5 p.Val385Ile Uncertain significance Single submitter
- CHRM5 p.Val432Ala Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All CHRM5 variants
Benign 2
- p.Glu412Lys Multiple submitters
- p.Pro191= Multiple submitters
Likely benign 3
- p.Ala292Thr Single submitter
- p.Leu321Phe Single submitter
- p.Thr281Ser Single submitter
Uncertain significance 54
- p.Ala165Thr Single submitter ⚠
- p.Ala269Pro Single submitter ⚠
- p.Ala339Val Single submitter ⚠
- p.Ala366Thr Single submitter ⚠
- p.Ala441Val Single submitter ⚠
- p.Ala9Gly Single submitter ⚠
- p.Arg128His Single submitter ⚠
- p.Arg139Leu Single submitter ⚠
- p.Arg142Cys Single submitter ⚠
- p.Arg142His Single submitter ⚠
- p.Arg218Gln Single submitter ⚠
- p.Arg24Cys Single submitter ⚠
- p.Arg255Leu Single submitter ⚠
- p.Arg26Lys Single submitter ⚠
- p.Arg275Cys Single submitter ⚠
- p.Arg275His Single submitter ⚠
- p.Arg500Lys Single submitter ⚠
- p.Arg513Gln Single submitter ⚠
- p.Arg95His Single submitter ⚠
- p.Asn293Ser Single submitter ⚠
- p.Asp318Tyr Single submitter ⚠
- p.Asp357Asn Single submitter ⚠
- p.Asp469Glu Single submitter ⚠
- p.Gln286Glu Single submitter ⚠
- p.Glu310Ala Single submitter ⚠
- p.Glu343Val Single submitter ⚠
- p.Gly196Arg Single submitter ⚠
- p.Gly389Arg Single submitter ⚠
- p.Gly527Arg Single submitter ⚠
- p.Ile447Val Single submitter
- p.Ile79Thr Single submitter ⚠
- p.Leu167Phe Single submitter ⚠
- p.Leu230Phe Single submitter
- p.Leu444Val Single submitter ⚠
- p.Leu50Phe Single submitter ⚠
- p.Leu510Phe Single submitter
- p.Lys353Arg Single submitter ⚠
- p.Lys522Arg Single submitter ⚠
- p.Met150Val Single submitter ⚠
- p.Met93Val Single submitter ⚠
- p.Phe337Cys Single submitter ⚠
- p.Pro144Arg Single submitter ⚠
- p.Pro408Leu Single submitter ⚠
- p.Pro422Arg Single submitter ⚠
- p.Pro457Leu Single submitter ⚠
- p.Ser125Gly Single submitter ⚠
- p.Ser285Phe Single submitter ⚠
- p.Ser59Asn Single submitter ⚠
- p.Thr10Ala Single submitter ⚠
- p.Thr301Ile Single submitter ⚠
- p.Val347Glu Single submitter ⚠
- p.Val377Gly Single submitter ⚠
- p.Val385Ile Single submitter ⚠
- p.Val432Ala Single submitter ⚠