CHST12 — 84 ClinVar variants
All ClinVar germline CHST12 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
1 Benign · 7 Likely benign · 76 Uncertain significance
Full CHST12 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CHST12 p.Ala301Asp Uncertain significance Single submitter
- CHST12 p.Ala316Val Uncertain significance Single submitter
- CHST12 p.Ala350Gly Uncertain significance Single submitter
- CHST12 p.Arg112Trp Uncertain significance Single submitter
- CHST12 p.Arg119Gln Uncertain significance Single submitter
- CHST12 p.Arg124Gln Uncertain significance Single submitter
- CHST12 p.Arg204His Uncertain significance Single submitter
- CHST12 p.Arg221Cys Uncertain significance Single submitter
- CHST12 p.Arg276Gln Uncertain significance Single submitter
- CHST12 p.Arg293Leu Uncertain significance Single submitter
- CHST12 p.Arg369Trp Uncertain significance Single submitter
- CHST12 p.Arg413Gln Uncertain significance Single submitter
- CHST12 p.Arg5Trp Uncertain significance Single submitter
- CHST12 p.Asn263Lys Uncertain significance Single submitter
- CHST12 p.Asn410Asp Uncertain significance Single submitter
- CHST12 p.Asp246Asn Uncertain significance Single submitter
- CHST12 p.Asp337His Uncertain significance Single submitter
- CHST12 p.Asp346Glu Uncertain significance Single submitter
- CHST12 p.Asp57Tyr Uncertain significance Single submitter
- CHST12 p.Asp65Glu Uncertain significance Single submitter
- CHST12 p.Asp82Asn Uncertain significance Single submitter
- CHST12 p.Gln351Glu Uncertain significance Single submitter
- CHST12 p.Gln354His Uncertain significance Single submitter
- CHST12 p.Glu205Lys Uncertain significance Single submitter
- CHST12 p.Glu87Asp Uncertain significance Single submitter
- CHST12 p.Gly193Ser Uncertain significance Single submitter
- CHST12 p.Ile158Met Uncertain significance Single submitter
- CHST12 p.Leu13Val Uncertain significance Single submitter
- CHST12 p.Leu402Pro Uncertain significance Single submitter
- CHST12 p.Lys269Thr Uncertain significance Single submitter
- CHST12 p.Lys72Arg Uncertain significance Single submitter
- CHST12 p.Lys72Asn Uncertain significance Single submitter
- CHST12 p.Met97Val Uncertain significance Single submitter
- CHST12 p.Pro108Leu Uncertain significance Single submitter
- CHST12 p.Pro140Leu Uncertain significance Single submitter
- CHST12 p.Pro247Ser Uncertain significance Single submitter
- CHST12 p.Pro331Leu Uncertain significance Single submitter
- CHST12 p.Pro366Ala Uncertain significance Single submitter
- CHST12 p.Pro366Arg Uncertain significance Single submitter
- CHST12 p.Pro47Leu Uncertain significance Single submitter
- CHST12 p.Pro54Leu Uncertain significance Single submitter
- CHST12 p.Ser100Thr Uncertain significance Single submitter
- CHST12 p.Ser211Asn Uncertain significance Single submitter
- CHST12 p.Ser39Phe Uncertain significance Single submitter
- CHST12 p.Thr2Ile Uncertain significance Single submitter
- CHST12 p.Thr61Arg Uncertain significance Single submitter
- CHST12 p.Thr88Met Uncertain significance Single submitter
- CHST12 p.Tyr336Cys Uncertain significance Single submitter
- CHST12 p.Tyr405Ser Uncertain significance Single submitter
- CHST12 p.Val181Glu Uncertain significance Single submitter
- CHST12 p.Val325Met Uncertain significance Single submitter
- CHST12 p.Val66Asp Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- CHST12 p.Arg197Cys Uncertain significance Single submitter
- CHST12 p.Arg201Cys Uncertain significance Single submitter
- CHST12 p.Arg268Cys Uncertain significance Single submitter
- CHST12 p.Arg293Cys Uncertain significance Single submitter
- CHST12 p.Arg327His Uncertain significance Single submitter
- CHST12 p.Arg360Trp Uncertain significance Single submitter
- CHST12 p.Gln333His Uncertain significance Single submitter
- CHST12 p.Gly130Cys Uncertain significance Single submitter
- CHST12 p.His281Asp Uncertain significance Single submitter
- CHST12 p.Leu328Phe Uncertain significance Single submitter
- CHST12 p.Leu9Pro Uncertain significance Single submitter
- CHST12 p.Lys218Asn Uncertain significance Single submitter
- CHST12 p.Phe259Leu Uncertain significance Single submitter
- CHST12 p.Pro195Arg Uncertain significance Single submitter
- CHST12 p.Pro203Leu Uncertain significance Single submitter
- CHST12 p.Thr312Ala Uncertain significance Single submitter
- CHST12 p.Trp26Arg Uncertain significance Single submitter
All CHST12 variants
Benign 1
- p.Ala210Gly Single submitter
Likely benign 7
- p.Ala288Val Single submitter
- p.Ala31= Single submitter
- p.Pro94Leu Single submitter
- p.Ser28Asn Single submitter
- p.Ser75Gly Single submitter
- p.Val16Ala Single submitter
- p.Thr312= No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 76
- p.Ala271Thr Single submitter
- p.Ala301Asp Single submitter ⚠
- p.Ala316Val Single submitter ⚠
- p.Ala350Gly Single submitter ⚠
- p.Arg112Trp Single submitter ⚠
- p.Arg119Gln Single submitter ⚠
- p.Arg124Gln Single submitter ⚠
- p.Arg197Cys Single submitter ⚠
- p.Arg201Cys Single submitter ⚠
- p.Arg204His Single submitter ⚠
- p.Arg221Cys Single submitter ⚠
- p.Arg228Cys Single submitter
- p.Arg228Gly Single submitter
- p.Arg268Cys Single submitter ⚠
- p.Arg276Gln Single submitter ⚠
- p.Arg293Cys Single submitter ⚠
- p.Arg293Leu Single submitter ⚠
- p.Arg327His Single submitter ⚠
- p.Arg360Trp Single submitter ⚠
- p.Arg369Trp Single submitter ⚠
- p.Arg389Lys Single submitter
- p.Arg413Gln Single submitter ⚠
- p.Arg5Trp Single submitter ⚠
- p.Asn263Lys Single submitter ⚠
- p.Asn410Asp Single submitter ⚠
- p.Asp246Asn Single submitter ⚠
- p.Asp337His Single submitter ⚠
- p.Asp346Glu Single submitter ⚠
- p.Asp57Tyr Single submitter ⚠
- p.Asp65Glu Single submitter ⚠
- p.Asp82Asn Single submitter ⚠
- p.Gln333His Single submitter ⚠
- p.Gln351Glu Single submitter ⚠
- p.Gln354His Single submitter ⚠
- p.Glu205Lys Single submitter ⚠
- p.Glu313Gly Single submitter
- p.Glu87Asp Single submitter ⚠
- p.Gly130Cys Single submitter ⚠
- p.Gly193Ser Single submitter ⚠
- p.His281Asp Single submitter ⚠
- p.Ile158Met Single submitter ⚠
- p.Leu13Val Single submitter ⚠
- p.Leu235Ile Single submitter
- p.Leu328Phe Single submitter ⚠
- p.Leu402Pro Single submitter ⚠
- p.Leu9Pro Single submitter ⚠
- p.Lys218Asn Single submitter ⚠
- p.Lys269Thr Single submitter ⚠
- p.Lys72Arg Single submitter ⚠
- p.Lys72Asn Single submitter ⚠
- p.Met97Val Single submitter ⚠
- p.Phe259Leu Single submitter ⚠
- p.Pro108Leu Single submitter ⚠
- p.Pro140Leu Single submitter ⚠
- p.Pro195Arg Single submitter ⚠
- p.Pro203Leu Single submitter ⚠
- p.Pro247Ser Single submitter ⚠
- p.Pro331Leu Single submitter ⚠
- p.Pro366Ala Single submitter ⚠
- p.Pro366Arg Single submitter ⚠
- p.Pro47Leu Single submitter ⚠
- p.Pro54Leu Single submitter ⚠
- p.Ser100Thr Single submitter ⚠
- p.Ser211Asn Single submitter ⚠
- p.Ser39Phe Single submitter ⚠
- p.Thr2Ile Single submitter ⚠
- p.Thr312Ala Single submitter ⚠
- p.Thr61Arg Single submitter ⚠
- p.Thr88Met Single submitter ⚠
- p.Trp26Arg Single submitter ⚠
- p.Tyr326Cys Single submitter
- p.Tyr336Cys Single submitter ⚠
- p.Tyr405Ser Single submitter ⚠
- p.Val181Glu Single submitter ⚠
- p.Val325Met Single submitter ⚠
- p.Val66Asp Single submitter ⚠