CHST15 — 85 ClinVar variants
All ClinVar germline CHST15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 79 flagged for review →
4 Benign · 2 Likely benign · 79 Uncertain significance
Full CHST15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 79
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 56
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CHST15 p.Ala241Val Uncertain significance Single submitter
- CHST15 p.Ala283Ser Uncertain significance Single submitter
- CHST15 p.Ala330Ser Uncertain significance Single submitter
- CHST15 p.Ala357Ser Uncertain significance Single submitter
- CHST15 p.Ala437Ser Uncertain significance Single submitter
- CHST15 p.Ala437Val Uncertain significance Single submitter
- CHST15 p.Ala557Val Uncertain significance Single submitter
- CHST15 p.Arg299His Uncertain significance Single submitter
- CHST15 p.Arg307His Uncertain significance Single submitter
- CHST15 p.Arg436Cys Uncertain significance Single submitter
- CHST15 p.Arg436His Uncertain significance Single submitter
- CHST15 p.Arg46Cys Uncertain significance Single submitter
- CHST15 p.Arg46His Uncertain significance Single submitter
- CHST15 p.Arg73Cys Uncertain significance Single submitter
- CHST15 p.Arg73His Uncertain significance Single submitter
- CHST15 p.Asn127Lys Uncertain significance Single submitter
- CHST15 p.Asn157Ser Uncertain significance Single submitter
- CHST15 p.Asn208Lys Uncertain significance Single submitter
- CHST15 p.Asn446Ser Uncertain significance Single submitter
- CHST15 p.Asn67His Uncertain significance Single submitter
- CHST15 p.Asp14His Uncertain significance Single submitter
- CHST15 p.Asp414Asn Uncertain significance Single submitter
- CHST15 p.Asp432Val Uncertain significance Single submitter
- CHST15 p.Gln137Leu Uncertain significance Single submitter
- CHST15 p.Gln51Lys Uncertain significance Single submitter
- CHST15 p.Glu126Lys Uncertain significance Single submitter
- CHST15 p.Glu59Lys Uncertain significance Single submitter
- CHST15 p.Gly15Ser Uncertain significance Single submitter
- CHST15 p.Gly238Ser Uncertain significance Single submitter
- CHST15 p.Gly25Glu Uncertain significance Single submitter
- CHST15 p.Gly30Val Uncertain significance Single submitter
- CHST15 p.Gly368Ser Uncertain significance Single submitter
- CHST15 p.His134Arg Uncertain significance Single submitter
- CHST15 p.His136Leu Uncertain significance Single submitter
- CHST15 p.His239Tyr Uncertain significance Single submitter
- CHST15 p.His244Gln Uncertain significance Single submitter
- CHST15 p.His322Arg Uncertain significance Single submitter
- CHST15 p.His322Gln Uncertain significance Single submitter
- CHST15 p.Ile531Ser Uncertain significance Single submitter
- CHST15 p.Leu176Pro Uncertain significance Single submitter
- CHST15 p.Leu240Pro Uncertain significance Single submitter
- CHST15 p.Lys280Arg Uncertain significance Single submitter
- CHST15 p.Lys75Glu Uncertain significance Single submitter
- CHST15 p.Met52Lys Uncertain significance Single submitter
- CHST15 p.Phe45Leu Uncertain significance Single submitter
- CHST15 p.Pro198Ser Uncertain significance Single submitter
- CHST15 p.Pro520Thr Uncertain significance Single submitter
- CHST15 p.Thr359Met Uncertain significance Single submitter
- CHST15 p.Thr366Met Uncertain significance Single submitter
- CHST15 p.Thr374Met Uncertain significance Single submitter
- CHST15 p.Thr560Ala Uncertain significance Single submitter
- CHST15 p.Tyr257His Uncertain significance Single submitter
- CHST15 p.Val219Ala Uncertain significance Single submitter
- CHST15 p.Val219Met Uncertain significance Single submitter
- CHST15 p.Val279Phe Uncertain significance Single submitter
- CHST15 p.Val83Ile Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- CHST15 p.Ala321Thr Uncertain significance Single submitter
- CHST15 p.Ala412Thr Uncertain significance Single submitter
- CHST15 p.Ala548Val Uncertain significance Single submitter
- CHST15 p.Arg226Cys Uncertain significance Single submitter
- CHST15 p.Arg274Trp Uncertain significance Single submitter
- CHST15 p.Arg477His Uncertain significance Single submitter
- CHST15 p.Asp271Gly Uncertain significance Single submitter
- CHST15 p.Asp553Asn Uncertain significance Single submitter
- CHST15 p.Gln424Leu Uncertain significance Single submitter
- CHST15 p.Glu203Lys Uncertain significance Single submitter
- CHST15 p.Glu311Gly Uncertain significance Single submitter
- CHST15 p.Glu369Asp Uncertain significance Single submitter
- CHST15 p.Glu421Val Uncertain significance Single submitter
- CHST15 p.Gly206Glu Uncertain significance Single submitter
- CHST15 p.Leu240Val Uncertain significance Single submitter
- CHST15 p.Phe493Leu Uncertain significance Single submitter
- CHST15 p.Thr166Met Uncertain significance Single submitter
- CHST15 p.Thr215Ile Uncertain significance Single submitter
- CHST15 p.Thr36Met Uncertain significance Single submitter
- CHST15 p.Tyr221His Uncertain significance Single submitter
- CHST15 p.Tyr308Ser Uncertain significance Single submitter
- CHST15 p.Val439Ile Uncertain significance Single submitter
- CHST15 p.Val550Asp Uncertain significance Single submitter
All CHST15 variants
Benign 4
- p.Ala16Thr Multiple submitters
- p.Arg224= Multiple submitters
- c.1347+19del Single submitter
- p.Pro371= Single submitter
Likely benign 2
- p.Gln24Arg Single submitter
- p.Ser49Gly Single submitter
Uncertain significance 79
- p.Ala241Val Single submitter ⚠
- p.Ala283Ser Single submitter ⚠
- p.Ala321Thr Single submitter ⚠
- p.Ala330Ser Single submitter ⚠
- p.Ala357Ser Single submitter ⚠
- p.Ala412Thr Single submitter ⚠
- p.Ala437Ser Single submitter ⚠
- p.Ala437Val Single submitter ⚠
- p.Ala548Val Single submitter ⚠
- p.Ala557Val Single submitter ⚠
- p.Arg226Cys Single submitter ⚠
- p.Arg274Trp Single submitter ⚠
- p.Arg299His Single submitter ⚠
- p.Arg307His Single submitter ⚠
- p.Arg436Cys Single submitter ⚠
- p.Arg436His Single submitter ⚠
- p.Arg46Cys Single submitter ⚠
- p.Arg46His Single submitter ⚠
- p.Arg477His Single submitter ⚠
- p.Arg73Cys Single submitter ⚠
- p.Arg73His Single submitter ⚠
- p.Asn127Lys Single submitter ⚠
- p.Asn157Ser Single submitter ⚠
- p.Asn208Lys Single submitter ⚠
- p.Asn446Ser Single submitter ⚠
- p.Asn67His Single submitter ⚠
- p.Asp14His Single submitter ⚠
- p.Asp271Gly Single submitter ⚠
- p.Asp414Asn Single submitter ⚠
- p.Asp432Val Single submitter ⚠
- p.Asp553Asn Single submitter ⚠
- p.Gln137Leu Single submitter ⚠
- p.Gln424Leu Single submitter ⚠
- p.Gln51Lys Single submitter ⚠
- p.Glu126Lys Single submitter ⚠
- p.Glu203Lys Single submitter ⚠
- p.Glu311Gly Single submitter ⚠
- p.Glu369Asp Single submitter ⚠
- p.Glu421Val Single submitter ⚠
- p.Glu59Lys Single submitter ⚠
- p.Gly15Ser Single submitter ⚠
- p.Gly206Glu Single submitter ⚠
- p.Gly238Ser Single submitter ⚠
- p.Gly25Glu Single submitter ⚠
- p.Gly30Val Single submitter ⚠
- p.Gly368Ser Single submitter ⚠
- p.His134Arg Single submitter ⚠
- p.His136Leu Single submitter ⚠
- p.His239Tyr Single submitter ⚠
- p.His244Gln Single submitter ⚠
- p.His322Arg Single submitter ⚠
- p.His322Gln Single submitter ⚠
- p.Ile531Ser Single submitter ⚠
- p.Leu176Pro Single submitter ⚠
- p.Leu240Pro Single submitter ⚠
- p.Leu240Val Single submitter ⚠
- p.Lys280Arg Single submitter ⚠
- p.Lys75Glu Single submitter ⚠
- p.Met52Lys Single submitter ⚠
- p.Phe45Leu Single submitter ⚠
- p.Phe493Leu Single submitter ⚠
- p.Pro198Ser Single submitter ⚠
- p.Pro520Thr Single submitter ⚠
- p.Thr166Met Single submitter ⚠
- p.Thr215Ile Single submitter ⚠
- p.Thr359Met Single submitter ⚠
- p.Thr366Met Single submitter ⚠
- p.Thr36Met Single submitter ⚠
- p.Thr374Met Single submitter ⚠
- p.Thr560Ala Single submitter ⚠
- p.Tyr221His Single submitter ⚠
- p.Tyr257His Single submitter ⚠
- p.Tyr308Ser Single submitter ⚠
- p.Val219Ala Single submitter ⚠
- p.Val219Met Single submitter ⚠
- p.Val279Phe Single submitter ⚠
- p.Val439Ile Single submitter ⚠
- p.Val550Asp Single submitter ⚠
- p.Val83Ile Single submitter ⚠