CHST2 — 67 ClinVar variants
All ClinVar germline CHST2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →
2 Likely benign · 65 Uncertain significance
Full CHST2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 66
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CHST2 p.Ala116Pro Uncertain significance Single submitter
- CHST2 p.Ala116Ser Uncertain significance Single submitter
- CHST2 p.Ala118Gly Uncertain significance Single submitter
- CHST2 p.Ala387Gly Uncertain significance Single submitter
- CHST2 p.Ala455Val Uncertain significance Single submitter
- CHST2 p.Ala476Thr Uncertain significance Single submitter
- CHST2 p.Ala63Thr Uncertain significance Single submitter
- CHST2 p.Ala63Val Uncertain significance Single submitter
- CHST2 p.Arg242His Uncertain significance Single submitter
- CHST2 p.Arg35Pro Uncertain significance Single submitter
- CHST2 p.Asn152Ser Uncertain significance Single submitter
- CHST2 p.Asp324Asn Uncertain significance Single submitter
- CHST2 p.Asp89Ala Uncertain significance Single submitter
- CHST2 p.Asp89Asn Uncertain significance Single submitter
- CHST2 p.Gln85Arg Uncertain significance Single submitter
- CHST2 p.Glu509Lys Uncertain significance Single submitter
- CHST2 p.Gly134Arg Uncertain significance Single submitter
- CHST2 p.Gly161Arg Uncertain significance Single submitter
- CHST2 p.Gly238Ser Uncertain significance Single submitter
- CHST2 p.Gly240Arg Uncertain significance Single submitter
- CHST2 p.Gly241Trp Uncertain significance Single submitter
- CHST2 p.Gly377Ser Uncertain significance Single submitter
- CHST2 p.Gly463Ser Uncertain significance Single submitter
- CHST2 p.Gly47Arg Uncertain significance Single submitter
- CHST2 p.His117Asn Uncertain significance Single submitter
- CHST2 p.His199Tyr Uncertain significance Single submitter
- CHST2 p.His419Arg Uncertain significance Single submitter
- CHST2 p.Ile328Phe Uncertain significance Single submitter
- CHST2 p.Leu318Gln Uncertain significance Single submitter
- CHST2 p.Leu65Val Uncertain significance Single submitter
- CHST2 p.Met366Ile Uncertain significance Single submitter
- CHST2 p.Met70Val Uncertain significance Single submitter
- CHST2 p.Phe442Leu Uncertain significance Single submitter
- CHST2 p.Pro26Arg Uncertain significance Single submitter
- CHST2 p.Pro502Ser Uncertain significance Single submitter
- CHST2 p.Ser239Gly Uncertain significance Single submitter
- CHST2 p.Thr154Ser Uncertain significance Single submitter
- CHST2 p.Thr435Ala Uncertain significance Single submitter
- CHST2 p.Thr459Ile Uncertain significance Single submitter
- CHST2 p.Tyr205Phe Uncertain significance Single submitter
- CHST2 p.Val197Leu Uncertain significance Single submitter
- CHST2 p.Val422Leu Uncertain significance Single submitter
- CHST2 p.Val470Ala Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- CHST2 p.Ala131Val Uncertain significance Single submitter
- CHST2 p.Ala24Val Uncertain significance Single submitter
- CHST2 p.Ala25Thr Uncertain significance Single submitter
- CHST2 p.Ala480Thr Uncertain significance Single submitter
- CHST2 p.Ala55Thr Uncertain significance Single submitter
- CHST2 p.Ala8Val Uncertain significance Single submitter
- CHST2 p.Arg16Gln Uncertain significance Single submitter
- CHST2 p.Arg16Trp Uncertain significance Single submitter
- CHST2 p.Arg278His Uncertain significance Single submitter
- CHST2 p.Arg296Cys Uncertain significance Single submitter
- CHST2 p.Arg52Gly Uncertain significance Single submitter
- CHST2 p.Asn475Ser Uncertain significance Single submitter
- CHST2 p.Glu293Gln Uncertain significance Single submitter
- CHST2 p.Gly240Val Uncertain significance Single submitter
- CHST2 p.His374Pro Uncertain significance Single submitter
- CHST2 p.Leu29Gln Uncertain significance Single submitter
- CHST2 p.Leu520Phe Uncertain significance Single submitter
- CHST2 p.Pro108Ser Uncertain significance Single submitter
- CHST2 p.Pro110Ser Uncertain significance Single submitter
- CHST2 p.Pro34Thr Uncertain significance Single submitter
- CHST2 p.Pro361Arg Uncertain significance Single submitter
- CHST2 p.Tyr62Cys Uncertain significance Single submitter
- CHST2 p.Val146Phe Likely benign Single submitter
All CHST2 variants
Likely benign 2
- p.Asn87Ser Single submitter
- p.Val146Phe Single submitter ⚠
Uncertain significance 65
- p.Ala116Pro Single submitter ⚠
- p.Ala116Ser Single submitter ⚠
- p.Ala118Gly Single submitter ⚠
- p.Ala131Val Single submitter ⚠
- p.Ala24Val Single submitter ⚠
- p.Ala25Thr Single submitter ⚠
- p.Ala387Gly Single submitter ⚠
- p.Ala455Val Single submitter ⚠
- p.Ala476Thr Single submitter ⚠
- p.Ala480Thr Single submitter ⚠
- p.Ala55Thr Single submitter ⚠
- p.Ala63Thr Single submitter ⚠
- p.Ala63Val Single submitter ⚠
- p.Ala8Val Single submitter ⚠
- p.Arg16Gln Single submitter ⚠
- p.Arg16Trp Single submitter ⚠
- p.Arg242His Single submitter ⚠
- p.Arg278His Single submitter ⚠
- p.Arg296Cys Single submitter ⚠
- p.Arg35Pro Single submitter ⚠
- p.Arg52Gly Single submitter ⚠
- p.Asn152Ser Single submitter ⚠
- p.Asn475Ser Single submitter ⚠
- p.Asp324Asn Single submitter ⚠
- p.Asp89Ala Single submitter ⚠
- p.Asp89Asn Single submitter ⚠
- p.Gln85Arg Single submitter ⚠
- p.Glu293Gln Single submitter ⚠
- p.Glu509Lys Single submitter ⚠
- p.Gly134Arg Single submitter ⚠
- p.Gly161Arg Single submitter ⚠
- p.Gly238Ser Single submitter ⚠
- p.Gly240Arg Single submitter ⚠
- p.Gly240Val Single submitter ⚠
- p.Gly241Trp Single submitter ⚠
- p.Gly377Ser Single submitter ⚠
- p.Gly463Ser Single submitter ⚠
- p.Gly47Arg Single submitter ⚠
- p.His117Asn Single submitter ⚠
- p.His199Tyr Single submitter ⚠
- p.His374Pro Single submitter ⚠
- p.His419Arg Single submitter ⚠
- p.Ile328Phe Single submitter ⚠
- p.Leu29Gln Single submitter ⚠
- p.Leu318Gln Single submitter ⚠
- p.Leu520Phe Single submitter ⚠
- p.Leu65Val Single submitter ⚠
- p.Met366Ile Single submitter ⚠
- p.Met70Val Single submitter ⚠
- p.Phe442Leu Single submitter ⚠
- p.Pro108Ser Single submitter ⚠
- p.Pro110Ser Single submitter ⚠
- p.Pro26Arg Single submitter ⚠
- p.Pro34Thr Single submitter ⚠
- p.Pro361Arg Single submitter ⚠
- p.Pro502Ser Single submitter ⚠
- p.Ser239Gly Single submitter ⚠
- p.Thr154Ser Single submitter ⚠
- p.Thr435Ala Single submitter ⚠
- p.Thr459Ile Single submitter ⚠
- p.Tyr205Phe Single submitter ⚠
- p.Tyr62Cys Single submitter ⚠
- p.Val197Leu Single submitter ⚠
- p.Val422Leu Single submitter ⚠
- p.Val470Ala Single submitter ⚠