CHST5 — 78 ClinVar variants
All ClinVar germline CHST5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
3 Benign · 9 Likely benign · 66 Uncertain significance
Full CHST5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CHST5 p.Ala11Val Uncertain significance Single submitter
- CHST5 p.Ala150Glu Uncertain significance Single submitter
- CHST5 p.Ala214Thr Uncertain significance Single submitter
- CHST5 p.Ala275Ser Uncertain significance Single submitter
- CHST5 p.Ala299Pro Uncertain significance Single submitter
- CHST5 p.Ala340Gly Uncertain significance Single submitter
- CHST5 p.Arg115His Uncertain significance Single submitter
- CHST5 p.Arg188Ser Uncertain significance Single submitter
- CHST5 p.Arg199Cys Uncertain significance Single submitter
- CHST5 p.Arg199His Uncertain significance Single submitter
- CHST5 p.Arg199Ser Uncertain significance Single submitter
- CHST5 p.Arg269His Uncertain significance Single submitter
- CHST5 p.Arg273His Uncertain significance Single submitter
- CHST5 p.Arg50Trp Uncertain significance Single submitter
- CHST5 p.Asn144Ser Uncertain significance Single submitter
- CHST5 p.Asn251Lys Uncertain significance Single submitter
- CHST5 p.Asp127Glu Uncertain significance Single submitter
- CHST5 p.Asp61Asn Uncertain significance Single submitter
- CHST5 p.Gln104Arg Uncertain significance Single submitter
- CHST5 p.Glu60Lys Uncertain significance Single submitter
- CHST5 p.Gly163Ser Uncertain significance Single submitter
- CHST5 p.Gly245Ser Uncertain significance Single submitter
- CHST5 p.Gly401Val Uncertain significance Single submitter
- CHST5 p.His221Gln Uncertain significance Single submitter
- CHST5 p.His85Leu Uncertain significance Single submitter
- CHST5 p.Leu24Val Uncertain significance Single submitter
- CHST5 p.Met22Ile Uncertain significance Single submitter
- CHST5 p.Met3Lys Uncertain significance Single submitter
- CHST5 p.Phe27Ile Uncertain significance Single submitter
- CHST5 p.Pro17Ser Uncertain significance Single submitter
- CHST5 p.Ser158Thr Uncertain significance Single submitter
- CHST5 p.Ser29Arg Uncertain significance Single submitter
- CHST5 p.Ser29Asn Uncertain significance Single submitter
- CHST5 p.Ser49Cys Uncertain significance Single submitter
- CHST5 p.Ser70Trp Uncertain significance Single submitter
- CHST5 p.Ser83Asn Uncertain significance Single submitter
- CHST5 p.Trp254Arg Uncertain significance Single submitter
- CHST5 p.Tyr384His Uncertain significance Single submitter
- CHST5 p.Val170Ile Uncertain significance Single submitter
- CHST5 p.Val370Ala Uncertain significance Single submitter
Predictors split 29
The independent predictors disagree with each other — read with care.
- CHST5 p.Arg6Trp Benign Multiple submitters
- CHST5 p.Ala108Pro Likely benign Single submitter
- CHST5 p.Ala159Thr Uncertain significance Single submitter
- CHST5 p.Ala348Thr Uncertain significance Single submitter
- CHST5 p.Ala57Val Uncertain significance Single submitter
- CHST5 p.Arg21Cys Uncertain significance Single submitter
- CHST5 p.Arg21His Uncertain significance Single submitter
- CHST5 p.Arg233Gln Uncertain significance Single submitter
- CHST5 p.Arg242Ser Uncertain significance Single submitter
- CHST5 p.Arg26Gly Uncertain significance Single submitter
- CHST5 p.Arg26Trp Uncertain significance Single submitter
- CHST5 p.Arg291Cys Uncertain significance Single submitter
- CHST5 p.Arg300Trp Uncertain significance Single submitter
- CHST5 p.Arg390Gly Uncertain significance Single submitter
- CHST5 p.Arg50Gln Likely benign Single submitter
- CHST5 p.Asn138His Uncertain significance Single submitter
- CHST5 p.Asp87Asn Uncertain significance Single submitter
- CHST5 p.Glu305Gly Uncertain significance Single submitter
- CHST5 p.Gly288Ser Uncertain significance Single submitter
- CHST5 p.Ile219Met Uncertain significance Single submitter
- CHST5 p.Leu209Val Uncertain significance Single submitter
- CHST5 p.Lys30Asn Uncertain significance Single submitter
- CHST5 p.Pro208Arg Uncertain significance Single submitter
- CHST5 p.Pro56Leu Uncertain significance Single submitter
- CHST5 p.Val193Met Uncertain significance Single submitter
- CHST5 p.Val229Met Uncertain significance Single submitter
- CHST5 p.Val34Met Uncertain significance Single submitter
- CHST5 p.Val63Ala Uncertain significance Single submitter
- CHST5 p.Val98Met Uncertain significance Single submitter
All CHST5 variants
Benign 3
- p.Ala311Thr Multiple submitters
- p.Arg6Trp Multiple submitters ⚠
- p.Glu322Gln Multiple submitters
Likely benign 9
- p.Ala108Pro Single submitter ⚠
- p.Arg349Leu Single submitter
- p.Arg50Gln Single submitter ⚠
- p.Gly373Ser Single submitter
- p.Ile246Thr Single submitter Rieger anomaly
- p.Ile264Val Single submitter
- p.Ser103= Single submitter
- p.Thr31Ala Single submitter
- p.Thr393Ser Single submitter
Uncertain significance 66
- p.Ala11Val Single submitter ⚠
- p.Ala150Glu Single submitter ⚠
- p.Ala159Thr Single submitter ⚠
- p.Ala214Thr Single submitter ⚠
- p.Ala275Ser Single submitter ⚠
- p.Ala299Pro Single submitter ⚠
- p.Ala340Gly Single submitter ⚠
- p.Ala348Thr Single submitter ⚠
- p.Ala57Val Single submitter ⚠
- p.Arg115His Single submitter ⚠
- p.Arg188Ser Single submitter ⚠
- p.Arg199Cys Single submitter ⚠
- p.Arg199His Single submitter ⚠
- p.Arg199Ser Single submitter ⚠
- p.Arg21Cys Single submitter ⚠
- p.Arg21His Single submitter ⚠
- p.Arg233Gln Single submitter ⚠
- p.Arg242Ser Single submitter ⚠
- p.Arg269His Single submitter ⚠
- p.Arg26Gly Single submitter ⚠
- p.Arg26Trp Single submitter ⚠
- p.Arg273His Single submitter ⚠
- p.Arg291Cys Single submitter ⚠
- p.Arg300Trp Single submitter ⚠
- p.Arg390Gly Single submitter ⚠
- p.Arg50Trp Single submitter ⚠
- p.Asn138His Single submitter ⚠
- p.Asn144Ser Single submitter ⚠
- p.Asn251Lys Single submitter ⚠
- p.Asp127Glu Single submitter ⚠
- p.Asp61Asn Single submitter ⚠
- p.Asp87Asn Single submitter ⚠
- p.Gln104Arg Single submitter ⚠
- p.Glu305Gly Single submitter ⚠
- p.Glu60Lys Single submitter ⚠
- p.Gly163Ser Single submitter ⚠
- p.Gly245Ser Single submitter ⚠
- p.Gly288Ser Single submitter ⚠
- p.Gly401Val Single submitter ⚠
- p.His221Gln Single submitter ⚠
- p.His85Leu Single submitter ⚠
- p.Ile219Met Single submitter ⚠
- p.Leu209Val Single submitter ⚠
- p.Leu24Val Single submitter ⚠
- p.Lys30Asn Single submitter ⚠
- p.Met22Ile Single submitter ⚠
- p.Met3Lys Single submitter ⚠
- p.Phe27Ile Single submitter ⚠
- p.Pro17Ser Single submitter ⚠
- p.Pro208Arg Single submitter ⚠
- p.Pro56Leu Single submitter ⚠
- p.Ser158Thr Single submitter ⚠
- p.Ser29Arg Single submitter ⚠
- p.Ser29Asn Single submitter ⚠
- p.Ser49Cys Single submitter ⚠
- p.Ser70Trp Single submitter ⚠
- p.Ser83Asn Single submitter ⚠
- p.Trp254Arg Single submitter ⚠
- p.Tyr384His Single submitter ⚠
- p.Val170Ile Single submitter ⚠
- p.Val193Met Single submitter ⚠
- p.Val229Met Single submitter ⚠
- p.Val34Met Single submitter ⚠
- p.Val370Ala Single submitter ⚠
- p.Val63Ala Single submitter ⚠
- p.Val98Met Single submitter ⚠