CHST7 — 42 ClinVar variants
All ClinVar germline CHST7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
1 Conflicting · 2 Benign · 3 Likely benign · 36 Uncertain significance
Full CHST7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CHST7 p.Ala172Thr Uncertain significance Single submitter
- CHST7 p.Ala413Ser Uncertain significance Single submitter
- CHST7 p.Ala413Thr Uncertain significance Single submitter
- CHST7 p.Ala453Val Uncertain significance Single submitter
- CHST7 p.Arg72Gln Uncertain significance Single submitter
- CHST7 p.Arg84Pro Uncertain significance Single submitter
- CHST7 p.Asn186Asp Uncertain significance Single submitter
- CHST7 p.Glu64Ala Uncertain significance Single submitter
- CHST7 p.Gly293Val Uncertain significance Single submitter
- CHST7 p.Gly361Arg Uncertain significance Single submitter
- CHST7 p.Leu192Val Uncertain significance Single submitter
- CHST7 p.Pro182Arg Uncertain significance Single submitter
- CHST7 p.Pro335Thr Uncertain significance Single submitter
- CHST7 p.Pro46Leu Uncertain significance Single submitter
- CHST7 p.Thr188Ser Uncertain significance Single submitter
- CHST7 p.Tyr375Cys Uncertain significance Single submitter
- CHST7 p.Val24Leu Uncertain significance Single submitter
- CHST7 p.Val28Ala Uncertain significance Single submitter
- CHST7 p.Val31Ile Uncertain significance Single submitter
- CHST7 p.Val320Leu Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- CHST7 p.Ala337Thr Uncertain significance Single submitter
- CHST7 p.Arg323Cys Uncertain significance Single submitter
- CHST7 p.Arg354Ser Uncertain significance Single submitter
- CHST7 p.Arg367Gln Uncertain significance Single submitter
- CHST7 p.Arg380Trp Conflicting Single submitter
- CHST7 p.Arg428Gly Uncertain significance Single submitter
- CHST7 p.Arg455His Uncertain significance Single submitter
- CHST7 p.Arg9Gly Uncertain significance Single submitter
- CHST7 p.Gly466Ser Uncertain significance Single submitter
- CHST7 p.Leu302Met Uncertain significance Single submitter
- CHST7 p.Met408Arg Uncertain significance Single submitter
- CHST7 p.Met408Thr Uncertain significance Single submitter
- CHST7 p.Phe404Leu Uncertain significance Single submitter
- CHST7 p.Pro174Leu Uncertain significance Single submitter
- CHST7 p.Ser148Arg Uncertain significance Single submitter
- CHST7 p.Val24Met Uncertain significance Single submitter
- CHST7 p.Val97Met Uncertain significance Single submitter
All CHST7 variants
Conflicting classifications of pathogenicity 1
- p.Arg380Trp Single submitter ⚠
Uncertain significance 36
- p.Ala172Thr Single submitter ⚠
- p.Ala337Thr Single submitter ⚠
- p.Ala413Ser Single submitter ⚠
- p.Ala413Thr Single submitter ⚠
- p.Ala453Val Single submitter ⚠
- p.Arg323Cys Single submitter ⚠
- p.Arg354Ser Single submitter ⚠
- p.Arg367Gln Single submitter ⚠
- p.Arg428Gly Single submitter ⚠
- p.Arg455His Single submitter ⚠
- p.Arg72Gln Single submitter ⚠
- p.Arg84Pro Single submitter ⚠
- p.Arg9Gly Single submitter ⚠
- p.Asn186Asp Single submitter ⚠
- p.Glu64Ala Single submitter ⚠
- p.Gly293Val Single submitter ⚠
- p.Gly361Arg Single submitter ⚠
- p.Gly466Ser Single submitter ⚠
- p.Leu192Val Single submitter ⚠
- p.Leu302Met Single submitter ⚠
- p.Met408Arg Single submitter ⚠
- p.Met408Thr Single submitter ⚠
- p.Phe404Leu Single submitter ⚠
- p.Pro174Leu Single submitter ⚠
- p.Pro182Arg Single submitter ⚠
- p.Pro335Thr Single submitter ⚠
- p.Pro46Leu Single submitter ⚠
- p.Ser148Arg Single submitter ⚠
- p.Thr188Ser Single submitter ⚠
- p.Tyr375Cys Single submitter ⚠
- p.Val24Leu Single submitter ⚠
- p.Val24Met Single submitter ⚠
- p.Val28Ala Single submitter ⚠
- p.Val31Ile Single submitter ⚠
- p.Val320Leu Single submitter ⚠
- p.Val97Met Single submitter ⚠