CIDEB — 39 ClinVar variants
All ClinVar germline CIDEB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
2 Likely benign · 37 Uncertain significance
Full CIDEB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CIDEB p.Ala154Asp Uncertain significance Single submitter
- CIDEB p.Ala203Pro Uncertain significance Single submitter
- CIDEB p.Ala63Glu Uncertain significance Single submitter
- CIDEB p.Arg122Pro Uncertain significance Single submitter
- CIDEB p.Arg144Gln Uncertain significance Single submitter
- CIDEB p.Arg215Cys Uncertain significance Single submitter
- CIDEB p.Arg215His Uncertain significance Single submitter
- CIDEB p.Arg56His Uncertain significance Single submitter
- CIDEB p.Cys41Tyr Uncertain significance Single submitter
- CIDEB p.Gln187Arg Uncertain significance Single submitter
- CIDEB p.Glu208Lys Uncertain significance Single submitter
- CIDEB p.Glu58Lys Uncertain significance Single submitter
- CIDEB p.Gly81Ala Uncertain significance Single submitter
- CIDEB p.Leu12Val Uncertain significance Single submitter
- CIDEB p.Leu75Arg Uncertain significance Single submitter
- CIDEB p.Leu92Met Uncertain significance Single submitter
- CIDEB p.Met100Ile Uncertain significance Single submitter
- CIDEB p.Met192Thr Uncertain significance Single submitter
- CIDEB p.Phe23Ser Uncertain significance Single submitter
- CIDEB p.Pro37Leu Uncertain significance Single submitter
- CIDEB p.Pro37Thr Uncertain significance Single submitter
- CIDEB p.Val138Met Uncertain significance Single submitter
- CIDEB p.Val174Ala Uncertain significance Single submitter
- CIDEB p.Val27Ile Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- CIDEB p.Arg25Gln Uncertain significance Single submitter
- CIDEB p.Arg25Trp Uncertain significance Single submitter
- CIDEB p.Arg39Cys Uncertain significance Single submitter
- CIDEB p.Arg39His Uncertain significance Single submitter
- CIDEB p.Arg48Gln Uncertain significance Single submitter
- CIDEB p.Arg48Trp Uncertain significance Single submitter
- CIDEB p.Asp85Asn Uncertain significance Single submitter
- CIDEB p.Cys98Arg Uncertain significance Single submitter
- CIDEB p.Cys98Tyr Uncertain significance Single submitter
- CIDEB p.Glu58Gly Uncertain significance Single submitter
- CIDEB p.Glu87Lys Uncertain significance Single submitter
- CIDEB p.Leu67Ile Uncertain significance Single submitter
- CIDEB p.Ser109Arg Uncertain significance Single submitter
All CIDEB variants
Likely benign 2
- p.Ala83Thr Single submitter
- p.Arg124Lys Single submitter
Uncertain significance 37
- p.Ala154Asp Single submitter ⚠
- p.Ala203Pro Single submitter ⚠
- p.Ala63Glu Single submitter ⚠
- p.Arg122Pro Single submitter ⚠
- p.Arg144Gln Single submitter ⚠
- p.Arg215Cys Single submitter ⚠
- p.Arg215His Single submitter ⚠
- p.Arg25Gln Single submitter ⚠
- p.Arg25Trp Single submitter ⚠
- p.Arg39Cys Single submitter ⚠
- p.Arg39His Single submitter ⚠
- p.Arg48Gln Single submitter ⚠
- p.Arg48Trp Single submitter ⚠
- p.Arg56His Single submitter ⚠
- p.Asp85Asn Single submitter ⚠
- p.Cys41Tyr Single submitter ⚠
- p.Cys98Arg Single submitter ⚠
- p.Cys98Tyr Single submitter ⚠
- p.Gln187Arg Single submitter ⚠
- p.Glu208Lys Single submitter ⚠
- p.Glu58Gly Single submitter ⚠
- p.Glu58Lys Single submitter ⚠
- p.Glu87Lys Single submitter ⚠
- p.Gly81Ala Single submitter ⚠
- p.Leu12Val Single submitter ⚠
- p.Leu67Ile Single submitter ⚠
- p.Leu75Arg Single submitter ⚠
- p.Leu92Met Single submitter ⚠
- p.Met100Ile Single submitter ⚠
- p.Met192Thr Single submitter ⚠
- p.Phe23Ser Single submitter ⚠
- p.Pro37Leu Single submitter ⚠
- p.Pro37Thr Single submitter ⚠
- p.Ser109Arg Single submitter ⚠
- p.Val138Met Single submitter ⚠
- p.Val174Ala Single submitter ⚠
- p.Val27Ile Single submitter ⚠