CLASRP — 126 ClinVar variants
All ClinVar germline CLASRP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 121 flagged for review →
5 Likely benign · 121 Uncertain significance
Full CLASRP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 121
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLASRP p.Ala231Val Uncertain significance Single submitter
- CLASRP p.Ala371Thr Uncertain significance Single submitter
- CLASRP p.Ala415Thr Uncertain significance Single submitter
- CLASRP p.Ala545Pro Uncertain significance Single submitter
- CLASRP p.Ala549Val Uncertain significance Single submitter
- CLASRP p.Ala561Thr Uncertain significance Single submitter
- CLASRP p.Asn122His Uncertain significance Single submitter
- CLASRP p.Asp72Tyr Uncertain significance Single submitter
- CLASRP p.Gln215Lys Uncertain significance Single submitter
- CLASRP p.Gln217Arg Uncertain significance Single submitter
- CLASRP p.Gln530Arg Uncertain significance Single submitter
- CLASRP p.Glu108Lys Uncertain significance Single submitter
- CLASRP p.Glu114Asp Uncertain significance Single submitter
- CLASRP p.Glu130Gly Uncertain significance Single submitter
- CLASRP p.Glu610Val Uncertain significance Single submitter
- CLASRP p.Gly321Val Uncertain significance Single submitter
- CLASRP p.Gly350Ala Uncertain significance Single submitter
- CLASRP p.Gly368Glu Uncertain significance Single submitter
- CLASRP p.Gly450Ala Uncertain significance Single submitter
- CLASRP p.Gly476Arg Uncertain significance Single submitter
- CLASRP p.Gly483Ser Uncertain significance Single submitter
- CLASRP p.His671Tyr Uncertain significance Single submitter
- CLASRP p.Leu541Pro Uncertain significance Single submitter
- CLASRP p.Pro95Ala Uncertain significance Single submitter
- CLASRP p.Pro95Ser Uncertain significance Single submitter
- CLASRP p.Ser443Ala Uncertain significance Single submitter
- CLASRP p.Ser447Phe Uncertain significance Single submitter
- CLASRP p.Thr171Ala Uncertain significance Single submitter
- CLASRP p.Thr509Pro Uncertain significance Single submitter
- CLASRP p.Thr93Ser Uncertain significance Single submitter
- CLASRP p.Trp422Arg Uncertain significance Single submitter
Predictors split 90
The independent predictors disagree with each other — read with care.
- CLASRP p.Ala157Thr Uncertain significance Single submitter
- CLASRP p.Ala346Gly Uncertain significance Single submitter
- CLASRP p.Ala592Val Uncertain significance Single submitter
- CLASRP p.Arg109Trp Uncertain significance Single submitter
- CLASRP p.Arg240Gln Uncertain significance Single submitter
- CLASRP p.Arg240Trp Uncertain significance Single submitter
- CLASRP p.Arg266Ser Uncertain significance Single submitter
- CLASRP p.Arg278Gln Uncertain significance Single submitter
- CLASRP p.Arg291His Uncertain significance Single submitter
- CLASRP p.Arg292Gln Uncertain significance Single submitter
- CLASRP p.Arg312Cys Uncertain significance Single submitter
- CLASRP p.Arg314Cys Uncertain significance Single submitter
- CLASRP p.Arg316His Uncertain significance Single submitter
- CLASRP p.Arg374Cys Uncertain significance Single submitter
- CLASRP p.Arg375Cys Uncertain significance Single submitter
- CLASRP p.Arg376Cys Uncertain significance Single submitter
- CLASRP p.Arg403Gly Uncertain significance Single submitter
- CLASRP p.Arg420Gly Uncertain significance Single submitter
- CLASRP p.Arg428Gly Uncertain significance Single submitter
- CLASRP p.Arg430Gly Uncertain significance Single submitter
- CLASRP p.Arg431Cys Uncertain significance Single submitter
- CLASRP p.Arg436Cys Uncertain significance Single submitter
- CLASRP p.Arg438Cys Uncertain significance Single submitter
- CLASRP p.Arg438Ser Uncertain significance Single submitter
- CLASRP p.Arg440Gln Uncertain significance Single submitter
- CLASRP p.Arg455Cys Uncertain significance Single submitter
- CLASRP p.Arg459Trp Uncertain significance Single submitter
- CLASRP p.Arg467Cys Uncertain significance Single submitter
- CLASRP p.Arg468Gly Uncertain significance Single submitter
- CLASRP p.Arg472Cys Uncertain significance Single submitter
- CLASRP p.Arg478Cys Uncertain significance Single submitter
- CLASRP p.Arg478His Uncertain significance Single submitter
- CLASRP p.Arg481Gln Uncertain significance Single submitter
- CLASRP p.Arg484Gln Uncertain significance Single submitter
- CLASRP p.Arg484Trp Uncertain significance Single submitter
- CLASRP p.Arg504Cys Uncertain significance Single submitter
- CLASRP p.Arg504His Uncertain significance Single submitter
- CLASRP p.Arg506Cys Uncertain significance Single submitter
- CLASRP p.Arg506His Uncertain significance Single submitter
- CLASRP p.Arg524Leu Uncertain significance Single submitter
- CLASRP p.Arg526Cys Uncertain significance Single submitter
- CLASRP p.Arg528His Uncertain significance Single submitter
- CLASRP p.Arg581Lys Uncertain significance Single submitter
- CLASRP p.Arg608Trp Uncertain significance Single submitter
- CLASRP p.Arg620His Uncertain significance Single submitter
- CLASRP p.Arg623His Uncertain significance Single submitter
- CLASRP p.Arg643Gln Uncertain significance Single submitter
- CLASRP p.Arg654Gln Uncertain significance Single submitter
- CLASRP p.Arg660Leu Uncertain significance Single submitter
- CLASRP p.Asp211Glu Uncertain significance Single submitter
- CLASRP p.Asp242Asn Uncertain significance Single submitter
- CLASRP p.Asp477Glu Uncertain significance Single submitter
- CLASRP p.Glu176Lys Uncertain significance Single submitter
- CLASRP p.Glu190Lys Uncertain significance Single submitter
- CLASRP p.Gly126Ser Uncertain significance Single submitter
- CLASRP p.Gly405Cys Uncertain significance Single submitter
- CLASRP p.Gly406Ala Uncertain significance Single submitter
- CLASRP p.Gly444Asp Uncertain significance Single submitter
- CLASRP p.Gly446Asp Uncertain significance Single submitter
- CLASRP p.Gly462Asp Uncertain significance Single submitter
- CLASRP p.Gly482Asp Uncertain significance Single submitter
- CLASRP p.Gly483Asp Uncertain significance Single submitter
- CLASRP p.Ile138Thr Uncertain significance Single submitter
- CLASRP p.Leu500Phe Uncertain significance Single submitter
- CLASRP p.Lys250Asn Uncertain significance Single submitter
- CLASRP p.Pro299Leu Uncertain significance Single submitter
- CLASRP p.Pro318Leu Uncertain significance Single submitter
- CLASRP p.Pro356His Uncertain significance Single submitter
- CLASRP p.Pro534Thr Uncertain significance Single submitter
- CLASRP p.Pro536Leu Uncertain significance Single submitter
- CLASRP p.Pro90Thr Uncertain significance Single submitter
- CLASRP p.Pro94Arg Uncertain significance Single submitter
- CLASRP p.Pro95Leu Uncertain significance Single submitter
- CLASRP p.Ser307Ala Uncertain significance Single submitter
- CLASRP p.Ser383Thr Uncertain significance Single submitter
- CLASRP p.Ser394Cys Uncertain significance Single submitter
- CLASRP p.Ser395Asn Uncertain significance Single submitter
- CLASRP p.Ser396Cys Uncertain significance Single submitter
- CLASRP p.Ser398Phe Uncertain significance Single submitter
- CLASRP p.Ser400Phe Uncertain significance Single submitter
- CLASRP p.Ser402Tyr Uncertain significance Single submitter
- CLASRP p.Ser427Cys Uncertain significance Single submitter
- CLASRP p.Ser521Asn Uncertain significance Single submitter
- CLASRP p.Thr166Asn Uncertain significance Single submitter
- CLASRP p.Thr171Met Uncertain significance Single submitter
- CLASRP p.Thr327Met Uncertain significance Single submitter
- CLASRP p.Trp422Cys Uncertain significance Single submitter
- CLASRP p.Tyr479Cys Uncertain significance Single submitter
- CLASRP p.Tyr656Cys Uncertain significance Single submitter
- CLASRP p.Val206Met Uncertain significance Single submitter
All CLASRP variants
Likely benign 5
- c.864-3T>C Single submitter
- p.Ala188= Single submitter
- p.Arg430_Arg431insSerArg Single submitter
- p.Pro544= Single submitter
- p.Thr93= Single submitter
Uncertain significance 121
- p.Ala157Thr Single submitter ⚠
- p.Ala231Val Single submitter ⚠
- p.Ala346Gly Single submitter ⚠
- p.Ala371Thr Single submitter ⚠
- p.Ala415Thr Single submitter ⚠
- p.Ala545Pro Single submitter ⚠
- p.Ala549Val Single submitter ⚠
- p.Ala561Thr Single submitter ⚠
- p.Ala592Val Single submitter ⚠
- p.Arg109Trp Single submitter ⚠
- p.Arg240Gln Single submitter ⚠
- p.Arg240Trp Single submitter ⚠
- p.Arg266Ser Single submitter ⚠
- p.Arg278Gln Single submitter ⚠
- p.Arg291His Single submitter ⚠
- p.Arg292Gln Single submitter ⚠
- p.Arg312Cys Single submitter ⚠
- p.Arg314Cys Single submitter ⚠
- p.Arg316His Single submitter ⚠
- p.Arg374Cys Single submitter ⚠
- p.Arg375Cys Single submitter ⚠
- p.Arg376Cys Single submitter ⚠
- p.Arg403Gly Single submitter ⚠
- p.Arg420Gly Single submitter ⚠
- p.Arg428Gly Single submitter ⚠
- p.Arg430Gly Single submitter ⚠
- p.Arg431Cys Single submitter ⚠
- p.Arg436Cys Single submitter ⚠
- p.Arg438Cys Single submitter ⚠
- p.Arg438Ser Single submitter ⚠
- p.Arg440Gln Single submitter ⚠
- p.Arg455Cys Single submitter ⚠
- p.Arg459Trp Single submitter ⚠
- p.Arg467Cys Single submitter ⚠
- p.Arg468Gly Single submitter ⚠
- p.Arg472Cys Single submitter ⚠
- p.Arg478Cys Single submitter ⚠
- p.Arg478His Single submitter ⚠
- p.Arg481Gln Single submitter ⚠
- p.Arg484Gln Single submitter ⚠
- p.Arg484Trp Single submitter ⚠
- p.Arg504Cys Single submitter ⚠
- p.Arg504His Single submitter ⚠
- p.Arg506Cys Single submitter ⚠
- p.Arg506His Single submitter ⚠
- p.Arg524Leu Single submitter ⚠
- p.Arg526Cys Single submitter ⚠
- p.Arg528His Single submitter ⚠
- p.Arg581Lys Single submitter ⚠
- p.Arg608Trp Single submitter ⚠
- p.Arg620His Single submitter ⚠
- p.Arg623His Single submitter ⚠
- p.Arg643Gln Single submitter ⚠
- p.Arg654Gln Single submitter ⚠
- p.Arg660Leu Single submitter ⚠
- p.Asn122His Single submitter ⚠
- p.Asp211Glu Single submitter ⚠
- p.Asp242Asn Single submitter ⚠
- p.Asp477Glu Single submitter ⚠
- p.Asp72Tyr Single submitter ⚠
- p.Gln215Lys Single submitter ⚠
- p.Gln217Arg Single submitter ⚠
- p.Gln530Arg Single submitter ⚠
- p.Glu108Lys Single submitter ⚠
- p.Glu114Asp Single submitter ⚠
- p.Glu130Gly Single submitter ⚠
- p.Glu176Lys Single submitter ⚠
- p.Glu190Lys Single submitter ⚠
- p.Glu610Val Single submitter ⚠
- p.Gly126Ser Single submitter ⚠
- p.Gly321Val Single submitter ⚠
- p.Gly350Ala Single submitter ⚠
- p.Gly368Glu Single submitter ⚠
- p.Gly405Cys Single submitter ⚠
- p.Gly406Ala Single submitter ⚠
- p.Gly444Asp Single submitter ⚠
- p.Gly446Asp Single submitter ⚠
- p.Gly450Ala Single submitter ⚠
- p.Gly462Asp Single submitter ⚠
- p.Gly476Arg Single submitter ⚠
- p.Gly482Asp Single submitter ⚠
- p.Gly483Asp Single submitter ⚠
- p.Gly483Ser Single submitter ⚠
- p.His671Tyr Single submitter ⚠
- p.Ile138Thr Single submitter ⚠
- p.Leu500Phe Single submitter ⚠
- p.Leu541Pro Single submitter ⚠
- p.Lys250Asn Single submitter ⚠
- p.Pro299Leu Single submitter ⚠
- p.Pro318Leu Single submitter ⚠
- p.Pro356His Single submitter ⚠
- p.Pro534Thr Single submitter ⚠
- p.Pro536Leu Single submitter ⚠
- p.Pro90Thr Single submitter ⚠
- p.Pro94Arg Single submitter ⚠
- p.Pro95Ala Single submitter ⚠
- p.Pro95Leu Single submitter ⚠
- p.Pro95Ser Single submitter ⚠
- p.Ser307Ala Single submitter ⚠
- p.Ser383Thr Single submitter ⚠
- p.Ser394Cys Single submitter ⚠
- p.Ser395Asn Single submitter ⚠
- p.Ser396Cys Single submitter ⚠
- p.Ser398Phe Single submitter ⚠
- p.Ser400Phe Single submitter ⚠
- p.Ser402Tyr Single submitter ⚠
- p.Ser427Cys Single submitter ⚠
- p.Ser443Ala Single submitter ⚠
- p.Ser447Phe Single submitter ⚠
- p.Ser521Asn Single submitter ⚠
- p.Thr166Asn Single submitter ⚠
- p.Thr171Ala Single submitter ⚠
- p.Thr171Met Single submitter ⚠
- p.Thr327Met Single submitter ⚠
- p.Thr509Pro Single submitter ⚠
- p.Thr93Ser Single submitter ⚠
- p.Trp422Arg Single submitter ⚠
- p.Trp422Cys Single submitter ⚠
- p.Tyr479Cys Single submitter ⚠
- p.Tyr656Cys Single submitter ⚠
- p.Val206Met Single submitter ⚠