CLDN8 — 40 ClinVar variants
All ClinVar germline CLDN8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
3 Benign · 2 Likely benign · 35 Uncertain significance
Full CLDN8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLDN8 p.Ala180Val Uncertain significance Single submitter
- CLDN8 p.Ala86Thr Uncertain significance Single submitter
- CLDN8 p.Asp110Asn Uncertain significance Single submitter
- CLDN8 p.Glu112Lys Uncertain significance Single submitter
- CLDN8 p.Gly130Val Uncertain significance Single submitter
- CLDN8 p.Gly15Asp Uncertain significance Single submitter
- CLDN8 p.Gly168Glu Uncertain significance Single submitter
- CLDN8 p.Gly179Arg Uncertain significance Single submitter
- CLDN8 p.His117Tyr Uncertain significance Single submitter
- CLDN8 p.Lys207Ile Uncertain significance Single submitter
- CLDN8 p.Lys213Asn Uncertain significance Single submitter
- CLDN8 p.Pro28Ser Uncertain significance Single submitter
- CLDN8 p.Ser138Ile Uncertain significance Single submitter
- CLDN8 p.Ser151Leu Uncertain significance Single submitter
- CLDN8 p.Thr204Ala Uncertain significance Single submitter
- CLDN8 p.Val32Ala Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- CLDN8 p.Glu190Gly Uncertain significance Single submitter
- CLDN8 p.Gly101Ser Uncertain significance Single submitter
- CLDN8 p.Gly109Glu Uncertain significance Single submitter
- CLDN8 p.Gly130Ala Uncertain significance Single submitter
- CLDN8 p.Gly212Arg Uncertain significance Single submitter
- CLDN8 p.Ile36Thr Uncertain significance Single submitter
- CLDN8 p.Ile40Val Uncertain significance Single submitter
- CLDN8 p.Leu134Phe Uncertain significance Single submitter
- CLDN8 p.Met52Lys Uncertain significance Single submitter
- CLDN8 p.Met62Thr Uncertain significance Single submitter
- CLDN8 p.Pro216Leu Benign Single submitter
- CLDN8 p.Ser201Phe Uncertain significance Single submitter
- CLDN8 p.Ser208Arg Likely benign Single submitter
- CLDN8 p.Ser208Ile Uncertain significance Single submitter
- CLDN8 p.Thr205Ile Uncertain significance Single submitter
- CLDN8 p.Tyr67His Uncertain significance Single submitter
- CLDN8 p.Val153Glu Uncertain significance Single submitter
- CLDN8 p.Val155Phe Uncertain significance Single submitter
- CLDN8 p.Val22Ala Uncertain significance Single submitter
All CLDN8 variants
Benign 3
- p.Ala94Val Multiple submitters
- p.Met97Thr Multiple submitters
- p.Pro216Leu Single submitter ⚠
Likely benign 2
- p.Phe46Leu Single submitter
- p.Ser208Arg Single submitter ⚠
Uncertain significance 35
- p.Ala180Val Single submitter ⚠
- p.Ala86Thr Single submitter ⚠
- p.Asp110Asn Single submitter ⚠
- p.Glu112Lys Single submitter ⚠
- p.Glu190Gly Single submitter ⚠
- p.Gly101Ser Single submitter ⚠
- p.Gly109Glu Single submitter ⚠
- p.Gly130Ala Single submitter ⚠
- p.Gly130Val Single submitter ⚠
- p.Gly15Asp Single submitter ⚠
- p.Gly168Glu Single submitter ⚠
- p.Gly179Arg Single submitter ⚠
- p.Gly212Arg Single submitter ⚠
- p.His117Tyr Single submitter ⚠
- p.Ile36Thr Single submitter ⚠
- p.Ile40Val Single submitter ⚠
- p.Leu134Phe Single submitter ⚠
- p.Lys207Ile Single submitter ⚠
- p.Lys213Asn Single submitter ⚠
- p.Met52Lys Single submitter ⚠
- p.Met62Thr Single submitter ⚠
- p.Pro28Ser Single submitter ⚠
- p.Ser138Ile Single submitter ⚠
- p.Ser151Leu Single submitter ⚠
- p.Ser201Phe Single submitter ⚠
- p.Ser208Ile Single submitter ⚠
- p.Thr204Ala Single submitter ⚠
- p.Thr205Ile Single submitter ⚠
- p.Tyr67His Single submitter ⚠
- p.Val153Glu Single submitter ⚠
- p.Val155Phe Single submitter ⚠
- p.Val22Ala Single submitter ⚠
- p.Val32Ala Single submitter ⚠
- p.Cys54Ter No assertion criteria
- p.Leu120= No assertion criteria