CLEC4A — 37 ClinVar variants
All ClinVar germline CLEC4A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
1 Benign · 6 Likely benign · 30 Uncertain significance
Full CLEC4A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLEC4A p.Arg194Cys Uncertain significance Multiple submitters
- CLEC4A p.Ala102Pro Uncertain significance Single submitter
- CLEC4A p.Arg174Gln Uncertain significance Single submitter
- CLEC4A p.Arg202His Uncertain significance Single submitter
- CLEC4A p.Arg209His Uncertain significance Single submitter
- CLEC4A p.Asp198Gly Uncertain significance Single submitter
- CLEC4A p.Cys230Tyr Uncertain significance Single submitter
- CLEC4A p.Ile21Phe Uncertain significance Single submitter
- CLEC4A p.Leu84Met Uncertain significance Single submitter
- CLEC4A p.Lys234Gln Uncertain significance Single submitter
- CLEC4A p.Phe154Ser Uncertain significance Single submitter
- CLEC4A p.Pro225Ser Uncertain significance Single submitter
- CLEC4A p.Ser29Cys Uncertain significance Single submitter
- CLEC4A p.Ser3Leu Uncertain significance Single submitter
- CLEC4A p.Thr101Ile Uncertain significance Single submitter
- CLEC4A p.Thr80Ile Uncertain significance Single submitter
- CLEC4A p.Val165Met Uncertain significance Single submitter
- CLEC4A p.Val92Ala Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- CLEC4A p.Arg202Cys Uncertain significance Single submitter
- CLEC4A p.Arg209Cys Uncertain significance Single submitter
- CLEC4A p.Asn185Asp Uncertain significance Single submitter
- CLEC4A p.Gln226Pro Uncertain significance Single submitter
- CLEC4A p.Gly216Asp Uncertain significance Single submitter
- CLEC4A p.His140Tyr Uncertain significance Single submitter
- CLEC4A p.Ile144Thr Uncertain significance Single submitter
- CLEC4A p.Leu76Pro Uncertain significance Single submitter
- CLEC4A p.Ser104Cys Uncertain significance Single submitter
- CLEC4A p.Ser197Cys Uncertain significance Single submitter
- CLEC4A p.Tyr184Cys Uncertain significance Single submitter
All CLEC4A variants
Benign 1
- p.Ter238Arg Multiple submitters
Likely benign 6
- p.Arg194His Single submitter
- p.Glu231Lys Single submitter
- p.Ile21Thr Single submitter
- p.Pro43Ser Single submitter
- p.Ser197Asn Single submitter
- p.Val98Met Single submitter
Uncertain significance 30
- p.Arg194Cys Multiple submitters ⚠
- p.Ala102Pro Single submitter ⚠
- p.Arg174Gln Single submitter ⚠
- p.Arg202Cys Single submitter ⚠
- p.Arg202His Single submitter ⚠
- p.Arg209Cys Single submitter ⚠
- p.Arg209His Single submitter ⚠
- p.Asn185Asp Single submitter ⚠
- p.Asn95fs Single submitter
- p.Asp198Gly Single submitter ⚠
- p.Cys230Tyr Single submitter ⚠
- p.Gln226Pro Single submitter ⚠
- p.Gly216Asp Single submitter ⚠
- p.His140Tyr Single submitter ⚠
- p.Ile144Thr Single submitter ⚠
- p.Ile21Phe Single submitter ⚠
- p.Leu76Pro Single submitter ⚠
- p.Leu84Met Single submitter ⚠
- p.Lys234Gln Single submitter ⚠
- p.Phe154Ser Single submitter ⚠
- p.Pro225Ser Single submitter ⚠
- p.Ser104Cys Single submitter ⚠
- p.Ser197Cys Single submitter ⚠
- p.Ser29Cys Single submitter ⚠
- p.Ser3Leu Single submitter ⚠
- p.Thr101Ile Single submitter ⚠
- p.Thr80Ile Single submitter ⚠
- p.Tyr184Cys Single submitter ⚠
- p.Val165Met Single submitter ⚠
- p.Val92Ala Single submitter ⚠