CLEC4D — 40 ClinVar variants
All ClinVar germline CLEC4D variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
1 Benign · 4 Likely benign · 35 Uncertain significance
Full CLEC4D gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLEC4D p.Ala90Gly Uncertain significance Single submitter
- CLEC4D p.Arg205Thr Uncertain significance Single submitter
- CLEC4D p.Cys199Phe Uncertain significance Single submitter
- CLEC4D p.Gln153Arg Uncertain significance Single submitter
- CLEC4D p.Glu125Lys Uncertain significance Single submitter
- CLEC4D p.Glu72Lys Uncertain significance Single submitter
- CLEC4D p.Gly54Glu Uncertain significance Single submitter
- CLEC4D p.His15Leu Uncertain significance Single submitter
- CLEC4D p.His170Arg Uncertain significance Single submitter
- CLEC4D p.His170Gln Uncertain significance Single submitter
- CLEC4D p.Ile206Val Uncertain significance Single submitter
- CLEC4D p.Ile67Val Uncertain significance Single submitter
- CLEC4D p.Leu73Pro Uncertain significance Single submitter
- CLEC4D p.Leu73Val Uncertain significance Single submitter
- CLEC4D p.Leu99Phe Uncertain significance Single submitter
- CLEC4D p.Lys57Arg Uncertain significance Single submitter
- CLEC4D p.Phe46Ser Uncertain significance Single submitter
- CLEC4D p.Thr100Ala Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- CLEC4D p.Ala117Ser Uncertain significance Single submitter
- CLEC4D p.Ala126Thr Uncertain significance Single submitter
- CLEC4D p.Ala37Glu Uncertain significance Single submitter
- CLEC4D p.Arg110Ser Uncertain significance Single submitter
- CLEC4D p.Arg138Trp Uncertain significance Single submitter
- CLEC4D p.Arg155Cys Uncertain significance Single submitter
- CLEC4D p.Asp136Val Uncertain significance Single submitter
- CLEC4D p.Cys66Phe Uncertain significance Single submitter
- CLEC4D p.Cys83Gly Uncertain significance Single submitter
- CLEC4D p.Glu109Lys Uncertain significance Single submitter
- CLEC4D p.Gly152Ser Uncertain significance Single submitter
- CLEC4D p.Leu135Met Uncertain significance Single submitter
- CLEC4D p.Leu145Val Uncertain significance Single submitter
- CLEC4D p.Leu64Ile Uncertain significance Single submitter
- CLEC4D p.Pro98His Uncertain significance Single submitter
- CLEC4D p.Thr104Met Uncertain significance Single submitter
- CLEC4D p.Thr160Met Likely benign Single submitter
- CLEC4D p.Val184Phe Uncertain significance Single submitter
All CLEC4D variants
Benign 1
- p.Ser32Gly Multiple submitters
Likely benign 4
- p.Ile86Val Single submitter
- p.Phe201Ser Single submitter
- p.Thr160Met Single submitter ⚠
- p.Glu59= No assertion criteria
Uncertain significance 35
- p.Ala117Ser Single submitter ⚠
- p.Ala126Thr Single submitter ⚠
- p.Ala37Glu Single submitter ⚠
- p.Ala90Gly Single submitter ⚠
- p.Arg110Ser Single submitter ⚠
- p.Arg138Trp Single submitter ⚠
- p.Arg155Cys Single submitter ⚠
- p.Arg205Thr Single submitter ⚠
- p.Asp136Val Single submitter ⚠
- p.Cys199Phe Single submitter ⚠
- p.Cys66Phe Single submitter ⚠
- p.Cys83Gly Single submitter ⚠
- p.Gln153Arg Single submitter ⚠
- p.Glu109Lys Single submitter ⚠
- p.Glu125Lys Single submitter ⚠
- p.Glu72Lys Single submitter ⚠
- p.Gly152Ser Single submitter ⚠
- p.Gly54Glu Single submitter ⚠
- p.His15Leu Single submitter ⚠
- p.His170Arg Single submitter ⚠
- p.His170Gln Single submitter ⚠
- p.Ile206Val Single submitter ⚠
- p.Ile67Val Single submitter ⚠
- p.Leu135Met Single submitter ⚠
- p.Leu145Val Single submitter ⚠
- p.Leu64Ile Single submitter ⚠
- p.Leu73Pro Single submitter ⚠
- p.Leu73Val Single submitter ⚠
- p.Leu99Phe Single submitter ⚠
- p.Lys57Arg Single submitter ⚠
- p.Phe46Ser Single submitter ⚠
- p.Pro98His Single submitter ⚠
- p.Thr100Ala Single submitter ⚠
- p.Thr104Met Single submitter ⚠
- p.Val184Phe Single submitter ⚠