CLECL1 — 17 ClinVar variants
All ClinVar germline CLECL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 15 flagged for review →
2 Likely benign · 15 Uncertain significance
Full CLECL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 15
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLECL1 c.4-35C>A Uncertain significance Single submitter
- CLECL1 c.-27G>A Uncertain significance Single submitter
- CLECL1 c.-5G>C Uncertain significance Single submitter
- CLECL1 n.231T>C Uncertain significance Single submitter
- CLECL1 n.303G>A Uncertain significance Single submitter
- CLECL1 n.307G>A Uncertain significance Single submitter
- CLECL1 n.373A>C Uncertain significance Single submitter
- CLECL1 n.52A>G Uncertain significance Single submitter
- CLECL1 p.Ala8Val Uncertain significance Single submitter
- CLECL1 p.His36Arg Uncertain significance Single submitter
- CLECL1 p.Met84Thr Uncertain significance Single submitter
- CLECL1 p.Pro17Leu Uncertain significance Single submitter
- CLECL1 p.Val46Met Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All CLECL1 variants
Likely benign 2
- c.4-35C>T Single submitter
- p.Val46Leu Single submitter
Uncertain significance 15
- c.4-35C>A Single submitter ⚠
- c.-27G>A Single submitter ⚠
- c.-5G>C Single submitter ⚠
- n.231T>C Single submitter ⚠
- n.303G>A Single submitter ⚠
- n.307G>A Single submitter ⚠
- n.373A>C Single submitter ⚠
- n.52A>G Single submitter ⚠
- p.Ala8Val Single submitter ⚠
- p.His36Arg Single submitter ⚠
- p.Lys58Asn Single submitter ⚠
- p.Met84Thr Single submitter ⚠
- p.Pro17Leu Single submitter ⚠
- p.Tyr74Cys Single submitter ⚠
- p.Val46Met Single submitter ⚠