CMTM3 — 23 ClinVar variants
All ClinVar germline CMTM3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
23 Uncertain significance
Full CMTM3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CMTM3 p.Ala29Thr Uncertain significance Single submitter
- CMTM3 p.Ala61Gly Uncertain significance Single submitter
- CMTM3 p.Ala61Val Uncertain significance Single submitter
- CMTM3 p.Arg105Ser Uncertain significance Single submitter
- CMTM3 p.Arg28Cys Uncertain significance Single submitter
- CMTM3 p.Glu173Gly Uncertain significance Single submitter
- CMTM3 p.Gly17Ser Uncertain significance Single submitter
- CMTM3 p.Ile118Val Uncertain significance Single submitter
- CMTM3 p.Ile141Thr Uncertain significance Single submitter
- CMTM3 p.Pro14Thr Uncertain significance Single submitter
- CMTM3 p.Pro22Leu Uncertain significance Single submitter
- CMTM3 p.Pro22Ser Uncertain significance Single submitter
- CMTM3 p.Pro25Arg Uncertain significance Single submitter
- CMTM3 p.Ser179Leu Uncertain significance Single submitter
- CMTM3 p.Thr167Pro Uncertain significance Single submitter
- CMTM3 p.Thr168Ile Uncertain significance Single submitter
- CMTM3 p.Val142Leu Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All CMTM3 variants
Uncertain significance 23
- p.Ala29Thr Single submitter ⚠
- p.Ala61Gly Single submitter ⚠
- p.Ala61Pro Single submitter
- p.Ala61Val Single submitter ⚠
- p.Arg105Cys Single submitter ⚠
- p.Arg105Ser Single submitter ⚠
- p.Arg28Cys Single submitter ⚠
- p.Glu173Gly Single submitter ⚠
- p.Glu48Asp Single submitter ⚠
- p.Gly17Ser Single submitter ⚠
- p.Ile118Val Single submitter ⚠
- p.Ile141Thr Single submitter ⚠
- p.Pro14Thr Single submitter ⚠
- p.Pro22Leu Single submitter ⚠
- p.Pro22Ser Single submitter ⚠
- p.Pro25Arg Single submitter ⚠
- p.Ser179Leu Single submitter ⚠
- p.Thr119Arg Single submitter ⚠
- p.Thr167Pro Single submitter ⚠
- p.Thr168Ile Single submitter ⚠
- p.Tyr124Cys Single submitter
- p.Val142Leu Single submitter ⚠
- p.Val142Met Single submitter ⚠