CNNM1 — 123 ClinVar variants
All ClinVar germline CNNM1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 112 flagged for review →
10 Benign · 2 Likely benign · 111 Uncertain significance
Full CNNM1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 112
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 65
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CNNM1 p.Ala229Glu Uncertain significance Single submitter
- CNNM1 p.Ala694Val Uncertain significance Single submitter
- CNNM1 p.Arg126Pro Uncertain significance Single submitter
- CNNM1 p.Arg165Pro Uncertain significance Single submitter
- CNNM1 p.Arg210Leu Uncertain significance Single submitter
- CNNM1 p.Arg746Leu Uncertain significance Single submitter
- CNNM1 p.Arg783Trp Uncertain significance Single submitter
- CNNM1 p.Arg837Ser Uncertain significance Single submitter
- CNNM1 p.Arg844His Uncertain significance Single submitter
- CNNM1 p.Asn575Asp Uncertain significance Single submitter
- CNNM1 p.Asn93His Uncertain significance Single submitter
- CNNM1 p.Asp438Glu Uncertain significance Single submitter
- CNNM1 p.Cys897Arg Uncertain significance Single submitter
- CNNM1 p.Gln928Pro Uncertain significance Single submitter
- CNNM1 p.Glu340Gly Uncertain significance Single submitter
- CNNM1 p.Glu455Val Uncertain significance Single submitter
- CNNM1 p.Glu538Ala Uncertain significance Single submitter
- CNNM1 p.Glu58Asp Uncertain significance Single submitter
- CNNM1 p.Glu682Lys Uncertain significance Single submitter
- CNNM1 p.Glu745Lys Uncertain significance Single submitter
- CNNM1 p.Glu873Lys Uncertain significance Single submitter
- CNNM1 p.Gly129Glu Uncertain significance Single submitter
- CNNM1 p.Gly12Ser Uncertain significance Single submitter
- CNNM1 p.Gly191Glu Uncertain significance Single submitter
- CNNM1 p.Gly216Arg Uncertain significance Single submitter
- CNNM1 p.Gly299Val Uncertain significance Single submitter
- CNNM1 p.Gly311Ala Uncertain significance Single submitter
- CNNM1 p.Gly677Asp Uncertain significance Single submitter
- CNNM1 p.Gly820Asp Uncertain significance Single submitter
- CNNM1 p.Gly95Glu Uncertain significance Single submitter
- CNNM1 p.Ile321Val Uncertain significance Single submitter
- CNNM1 p.Ile478Val Uncertain significance Single submitter
- CNNM1 p.Leu479Phe Uncertain significance Single submitter
- CNNM1 p.Leu647Val Uncertain significance Single submitter
- CNNM1 p.Met765Leu Uncertain significance Single submitter
- CNNM1 p.Met804Thr Uncertain significance Single submitter
- CNNM1 p.Phe624Ser Uncertain significance Single submitter
- CNNM1 p.Pro127Leu Uncertain significance Single submitter
- CNNM1 p.Pro148Ser Uncertain significance Single submitter
- CNNM1 p.Pro221Ala Uncertain significance Single submitter
- CNNM1 p.Pro324Ser Uncertain significance Single submitter
- CNNM1 p.Pro802Ser Uncertain significance Single submitter
- CNNM1 p.Pro816Ser Uncertain significance Single submitter
- CNNM1 p.Pro829Arg Uncertain significance Single submitter
- CNNM1 p.Pro829Thr Uncertain significance Single submitter
- CNNM1 p.Pro851Arg Uncertain significance Single submitter
- CNNM1 p.Pro851Leu Uncertain significance Single submitter
- CNNM1 p.Pro851Ser Uncertain significance Single submitter
- CNNM1 p.Pro884Ser Uncertain significance Single submitter
- CNNM1 p.Pro934Leu Uncertain significance Single submitter
- CNNM1 p.Ser121Arg Uncertain significance Single submitter
- CNNM1 p.Ser459Arg Uncertain significance Single submitter
- CNNM1 p.Ser630Leu Uncertain significance Single submitter
- CNNM1 p.Thr332Ile Uncertain significance Single submitter
- CNNM1 p.Thr434Asn Uncertain significance Single submitter
- CNNM1 p.Thr517Ala Uncertain significance Single submitter
- CNNM1 p.Thr818Ile Uncertain significance Single submitter
- CNNM1 p.Tyr697His Uncertain significance Single submitter
- CNNM1 p.Tyr856Cys Uncertain significance Single submitter
- CNNM1 p.Val162Ala Uncertain significance Single submitter
- CNNM1 p.Val330Leu Uncertain significance Single submitter
- CNNM1 p.Val643Met Uncertain significance Single submitter
- CNNM1 p.Val713Met Uncertain significance Single submitter
- CNNM1 p.Val854Leu Uncertain significance Single submitter
-
CNNM1 p.Glu319Asp
Uncertain significance
No assertion criteria
breast ductal adenocarcinoma
Predictors split 47
The independent predictors disagree with each other — read with care.
- CNNM1 p.Ala103Asp Uncertain significance Single submitter
- CNNM1 p.Ala368Thr Likely benign Single submitter
- CNNM1 p.Ala383Thr Uncertain significance Single submitter
- CNNM1 p.Ala3Thr Uncertain significance Single submitter
- CNNM1 p.Ala7Val Uncertain significance Single submitter
- CNNM1 p.Ala8Thr Uncertain significance Single submitter
- CNNM1 p.Arg16Gln Uncertain significance Single submitter
- CNNM1 p.Arg225Leu Uncertain significance Single submitter
- CNNM1 p.Arg271Ser Uncertain significance Single submitter
- CNNM1 p.Arg278Ser Uncertain significance Single submitter
- CNNM1 p.Arg584Trp Uncertain significance Single submitter
- CNNM1 p.Arg602Leu Uncertain significance Single submitter
- CNNM1 p.Arg664Cys Uncertain significance Single submitter
- CNNM1 p.Arg728Gln Uncertain significance Single submitter
- CNNM1 p.Arg728Trp Uncertain significance Single submitter
- CNNM1 p.Arg738Cys Uncertain significance Single submitter
- CNNM1 p.Arg783Gln Uncertain significance Single submitter
- CNNM1 p.Arg819Trp Uncertain significance Single submitter
- CNNM1 p.Arg844Cys Uncertain significance Single submitter
- CNNM1 p.Asn642Asp Uncertain significance Single submitter
- CNNM1 p.Asn642Ser Uncertain significance Single submitter
- CNNM1 p.Asn665Ser Uncertain significance Single submitter
- CNNM1 p.Asp912Asn Uncertain significance Single submitter
- CNNM1 p.Glu455Gln Uncertain significance Single submitter
- CNNM1 p.Gly176Arg Uncertain significance Single submitter
- CNNM1 p.Gly751Asp Uncertain significance Single submitter
- CNNM1 p.Leu257Val Uncertain significance Single submitter
- CNNM1 p.Leu27Phe Uncertain significance Single submitter
- CNNM1 p.Leu833Phe Uncertain significance Single submitter
- CNNM1 p.Pro120His Uncertain significance Single submitter
- CNNM1 p.Pro35Ser Uncertain significance Single submitter
- CNNM1 p.Ser20Asn Uncertain significance Single submitter
- CNNM1 p.Ser262Leu Uncertain significance Single submitter
- CNNM1 p.Ser626Cys Uncertain significance Single submitter
- CNNM1 p.Ser718Gly Uncertain significance Single submitter
- CNNM1 p.Ser774Arg Uncertain significance Single submitter
- CNNM1 p.Ser944Cys Uncertain significance Single submitter
- CNNM1 p.Thr390Ile Uncertain significance Single submitter
- CNNM1 p.Thr393Met Uncertain significance Single submitter
- CNNM1 p.Thr599Met Uncertain significance Single submitter
- CNNM1 p.Thr832Met Uncertain significance Single submitter
- CNNM1 p.Thr889Met Uncertain significance Single submitter
- CNNM1 p.Val118Met Uncertain significance Single submitter
- CNNM1 p.Val13Ile Uncertain significance Single submitter
- CNNM1 p.Val372Met Uncertain significance Single submitter
- CNNM1 p.Val603Gly Uncertain significance Single submitter
- CNNM1 p.Val700Ile Uncertain significance Single submitter
All CNNM1 variants
Benign 10
- c.1717+145G>A Multiple submitters
- c.1858+55C>T Multiple submitters
- c.2340+88G>A Multiple submitters
- c.2776+92A>G Multiple submitters
- p.Ala222= Multiple submitters
- p.Arg819Gln Multiple submitters
- p.Asp828= Multiple submitters
- p.Val428= Multiple submitters
- c.2129-112C>A Single submitter
- c.2776+183C>A Single submitter
Likely benign 2
- p.Ala103= Single submitter
- p.Ala368Thr Single submitter ⚠
Uncertain significance 111
- p.Ala103Asp Single submitter ⚠
- p.Ala229Glu Single submitter ⚠
- p.Ala383Thr Single submitter ⚠
- p.Ala3Thr Single submitter ⚠
- p.Ala694Val Single submitter ⚠
- p.Ala7Val Single submitter ⚠
- p.Ala8Thr Single submitter ⚠
- p.Arg126Pro Single submitter ⚠
- p.Arg165Pro Single submitter ⚠
- p.Arg16Gln Single submitter ⚠
- p.Arg210Leu Single submitter ⚠
- p.Arg225Leu Single submitter ⚠
- p.Arg271Ser Single submitter ⚠
- p.Arg278Ser Single submitter ⚠
- p.Arg584Trp Single submitter ⚠
- p.Arg602Leu Single submitter ⚠
- p.Arg664Cys Single submitter ⚠
- p.Arg728Gln Single submitter ⚠
- p.Arg728Trp Single submitter ⚠
- p.Arg738Cys Single submitter ⚠
- p.Arg746Leu Single submitter ⚠
- p.Arg783Gln Single submitter ⚠
- p.Arg783Trp Single submitter ⚠
- p.Arg819Trp Single submitter ⚠
- p.Arg837Ser Single submitter ⚠
- p.Arg844Cys Single submitter ⚠
- p.Arg844His Single submitter ⚠
- p.Asn575Asp Single submitter ⚠
- p.Asn642Asp Single submitter ⚠
- p.Asn642Ser Single submitter ⚠
- p.Asn665Ser Single submitter ⚠
- p.Asn93His Single submitter ⚠
- p.Asp438Glu Single submitter ⚠
- p.Asp912Asn Single submitter ⚠
- p.Cys897Arg Single submitter ⚠
- p.Gln928Pro Single submitter ⚠
- p.Glu340Gly Single submitter ⚠
- p.Glu455Gln Single submitter ⚠
- p.Glu455Val Single submitter ⚠
- p.Glu538Ala Single submitter ⚠
- p.Glu58Asp Single submitter ⚠
- p.Glu682Lys Single submitter ⚠
- p.Glu745Lys Single submitter ⚠
- p.Glu873Lys Single submitter ⚠
- p.Gly129Glu Single submitter ⚠
- p.Gly12Ser Single submitter ⚠
- p.Gly176Arg Single submitter ⚠
- p.Gly191Glu Single submitter ⚠
- p.Gly216Arg Single submitter ⚠
- p.Gly299Val Single submitter ⚠
- p.Gly311Ala Single submitter ⚠
- p.Gly677Asp Single submitter ⚠
- p.Gly751Asp Single submitter ⚠
- p.Gly820Asp Single submitter ⚠
- p.Gly95Glu Single submitter ⚠
- p.Ile321Val Single submitter ⚠
- p.Ile478Val Single submitter ⚠
- p.Leu257Val Single submitter ⚠
- p.Leu27Phe Single submitter ⚠
- p.Leu479Phe Single submitter ⚠
- p.Leu647Val Single submitter ⚠
- p.Leu833Phe Single submitter ⚠
- p.Met765Leu Single submitter ⚠
- p.Met804Thr Single submitter ⚠
- p.Phe624Ser Single submitter ⚠
- p.Pro120His Single submitter ⚠
- p.Pro127Leu Single submitter ⚠
- p.Pro148Ser Single submitter ⚠
- p.Pro221Ala Single submitter ⚠
- p.Pro324Ser Single submitter ⚠
- p.Pro35Ser Single submitter ⚠
- p.Pro802Ser Single submitter ⚠
- p.Pro816Ser Single submitter ⚠
- p.Pro829Arg Single submitter ⚠
- p.Pro829Thr Single submitter ⚠
- p.Pro851Arg Single submitter ⚠
- p.Pro851Leu Single submitter ⚠
- p.Pro851Ser Single submitter ⚠
- p.Pro884Ser Single submitter ⚠
- p.Pro934Leu Single submitter ⚠
- p.Ser121Arg Single submitter ⚠
- p.Ser20Asn Single submitter ⚠
- p.Ser262Leu Single submitter ⚠
- p.Ser459Arg Single submitter ⚠
- p.Ser626Cys Single submitter ⚠
- p.Ser630Leu Single submitter ⚠
- p.Ser718Gly Single submitter ⚠
- p.Ser774Arg Single submitter ⚠
- p.Ser944Cys Single submitter ⚠
- p.Thr332Ile Single submitter ⚠
- p.Thr390Ile Single submitter ⚠
- p.Thr393Met Single submitter ⚠
- p.Thr434Asn Single submitter ⚠
- p.Thr517Ala Single submitter ⚠
- p.Thr599Met Single submitter ⚠
- p.Thr818Ile Single submitter ⚠
- p.Thr832Met Single submitter ⚠
- p.Thr889Met Single submitter ⚠
- p.Tyr697His Single submitter ⚠
- p.Tyr856Cys Single submitter ⚠
- p.Val118Met Single submitter ⚠
- p.Val13Ile Single submitter ⚠
- p.Val162Ala Single submitter ⚠
- p.Val330Leu Single submitter ⚠
- p.Val372Met Single submitter ⚠
- p.Val603Gly Single submitter ⚠
- p.Val643Met Single submitter ⚠
- p.Val700Ile Single submitter ⚠
- p.Val713Met Single submitter ⚠
- p.Val854Leu Single submitter ⚠
- p.Glu319Asp No assertion criteria breast ductal adenocarcinoma ⚠