CNOT10 — 80 ClinVar variants
All ClinVar germline CNOT10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 78 flagged for review →
2 Likely benign · 78 Uncertain significance
Full CNOT10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 78
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 49
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CNOT10 p.Ala11Gly Uncertain significance Single submitter
- CNOT10 p.Ala250Val Uncertain significance Single submitter
- CNOT10 p.Ala279Thr Uncertain significance Single submitter
- CNOT10 p.Ala305Val Uncertain significance Single submitter
- CNOT10 p.Ala669Val Uncertain significance Single submitter
- CNOT10 p.Arg124Gln Uncertain significance Single submitter
- CNOT10 p.Arg224Gln Uncertain significance Single submitter
- CNOT10 p.Asn184Ser Uncertain significance Single submitter
- CNOT10 p.Asn196Ser Uncertain significance Single submitter
- CNOT10 p.Asn33Lys Uncertain significance Single submitter
- CNOT10 p.Asn483Ser Uncertain significance Single submitter
- CNOT10 p.Asn706His Uncertain significance Single submitter
- CNOT10 p.Asp478Val Uncertain significance Single submitter
- CNOT10 p.Cys235Arg Uncertain significance Single submitter
- CNOT10 p.Cys293Tyr Uncertain significance Single submitter
- CNOT10 p.Cys361Ser Uncertain significance Single submitter
- CNOT10 p.Gln438Arg Uncertain significance Single submitter
- CNOT10 p.Gln561Arg Uncertain significance Single submitter
- CNOT10 p.Gln731Arg Uncertain significance Single submitter
- CNOT10 p.Glu100Asp Uncertain significance Single submitter
- CNOT10 p.Glu717Val Uncertain significance Single submitter
- CNOT10 p.Gly10Glu Uncertain significance Single submitter
- CNOT10 p.Gly413Ala Uncertain significance Single submitter
- CNOT10 p.Gly511Glu Uncertain significance Single submitter
- CNOT10 p.His14Arg Uncertain significance Single submitter
- CNOT10 p.His203Tyr Uncertain significance Single submitter
- CNOT10 p.His509Arg Uncertain significance Single submitter
- CNOT10 p.His667Tyr Uncertain significance Single submitter
- CNOT10 p.Ile218Thr Uncertain significance Single submitter
- CNOT10 p.Ile463Val Uncertain significance Single submitter
- CNOT10 p.Ile515Leu Uncertain significance Single submitter
- CNOT10 p.Ile515Val Uncertain significance Single submitter
- CNOT10 p.Ile730Thr Uncertain significance Single submitter
- CNOT10 p.Leu655Val Uncertain significance Single submitter
- CNOT10 p.Lys217Gln Uncertain significance Single submitter
- CNOT10 p.Lys564Thr Uncertain significance Single submitter
- CNOT10 p.Met101Val Uncertain significance Single submitter
- CNOT10 p.Met111Leu Uncertain significance Single submitter
- CNOT10 p.Met285Val Uncertain significance Single submitter
- CNOT10 p.Phe316Val Uncertain significance Single submitter
- CNOT10 p.Pro251Leu Uncertain significance Single submitter
- CNOT10 p.Pro631Ser Uncertain significance Single submitter
- CNOT10 p.Ser110Asn Uncertain significance Single submitter
- CNOT10 p.Ser457Thr Uncertain significance Single submitter
- CNOT10 p.Thr24Ser Uncertain significance Single submitter
- CNOT10 p.Thr714Ser Uncertain significance Single submitter
- CNOT10 p.Tyr163His Uncertain significance Single submitter
- CNOT10 p.Tyr355Asp Uncertain significance Single submitter
- CNOT10 p.Tyr429Ser Uncertain significance Single submitter
Predictors split 29
The independent predictors disagree with each other — read with care.
- CNOT10 p.Ala225Val Uncertain significance Single submitter
- CNOT10 p.Ala2Thr Uncertain significance Single submitter
- CNOT10 p.Ala319Ser Uncertain significance Single submitter
- CNOT10 p.Arg124Trp Uncertain significance Single submitter
- CNOT10 p.Arg292Thr Uncertain significance Single submitter
- CNOT10 p.Glu376Gln Uncertain significance Single submitter
- CNOT10 p.Glu529Lys Uncertain significance Single submitter
- CNOT10 p.Gly405Arg Uncertain significance Single submitter
- CNOT10 p.Ile160Val Uncertain significance Single submitter
- CNOT10 p.Ile218Leu Uncertain significance Single submitter
- CNOT10 p.Leu154Phe Uncertain significance Single submitter
- CNOT10 p.Leu155Ile Uncertain significance Single submitter
- CNOT10 p.Leu581Phe Uncertain significance Single submitter
- CNOT10 p.Lys480Arg Uncertain significance Single submitter
- CNOT10 p.Lys558Glu Uncertain significance Single submitter
- CNOT10 p.Met243Ile Uncertain significance Single submitter
- CNOT10 p.Met294Thr Uncertain significance Single submitter
- CNOT10 p.Met346Thr Uncertain significance Single submitter
- CNOT10 p.Met672Val Uncertain significance Single submitter
- CNOT10 p.Pro282Ser Uncertain significance Single submitter
- CNOT10 p.Ser20Cys Uncertain significance Single submitter
- CNOT10 p.Ser506Ile Uncertain significance Single submitter
- CNOT10 p.Ser603Phe Uncertain significance Single submitter
- CNOT10 p.Tyr159His Uncertain significance Single submitter
- CNOT10 p.Tyr315Cys Uncertain significance Single submitter
- CNOT10 p.Val118Ile Uncertain significance Single submitter
- CNOT10 p.Val151Met Uncertain significance Single submitter
- CNOT10 p.Val270Met Uncertain significance Single submitter
- CNOT10 p.Val712Met Uncertain significance Single submitter
All CNOT10 variants
Likely benign 2
- p.Asn183= Single submitter
- p.Asn33Ser Single submitter
Uncertain significance 78
- p.Ala11Gly Single submitter ⚠
- p.Ala225Val Single submitter ⚠
- p.Ala250Val Single submitter ⚠
- p.Ala279Thr Single submitter ⚠
- p.Ala2Thr Single submitter ⚠
- p.Ala305Val Single submitter ⚠
- p.Ala319Ser Single submitter ⚠
- p.Ala669Val Single submitter ⚠
- p.Arg124Gln Single submitter ⚠
- p.Arg124Trp Single submitter ⚠
- p.Arg224Gln Single submitter ⚠
- p.Arg292Thr Single submitter ⚠
- p.Asn184Ser Single submitter ⚠
- p.Asn196Ser Single submitter ⚠
- p.Asn33Lys Single submitter ⚠
- p.Asn483Ser Single submitter ⚠
- p.Asn706His Single submitter ⚠
- p.Asp478Val Single submitter ⚠
- p.Cys235Arg Single submitter ⚠
- p.Cys293Tyr Single submitter ⚠
- p.Cys361Ser Single submitter ⚠
- p.Gln438Arg Single submitter ⚠
- p.Gln561Arg Single submitter ⚠
- p.Gln731Arg Single submitter ⚠
- p.Glu100Asp Single submitter ⚠
- p.Glu376Gln Single submitter ⚠
- p.Glu529Lys Single submitter ⚠
- p.Glu717Val Single submitter ⚠
- p.Gly10Glu Single submitter ⚠
- p.Gly405Arg Single submitter ⚠
- p.Gly413Ala Single submitter ⚠
- p.Gly511Glu Single submitter ⚠
- p.His14Arg Single submitter ⚠
- p.His203Tyr Single submitter ⚠
- p.His509Arg Single submitter ⚠
- p.His667Tyr Single submitter ⚠
- p.Ile160Val Single submitter ⚠
- p.Ile218Leu Single submitter ⚠
- p.Ile218Thr Single submitter ⚠
- p.Ile463Val Single submitter ⚠
- p.Ile515Leu Single submitter ⚠
- p.Ile515Val Single submitter ⚠
- p.Ile730Thr Single submitter ⚠
- p.Leu154Phe Single submitter ⚠
- p.Leu155Ile Single submitter ⚠
- p.Leu581Phe Single submitter ⚠
- p.Leu655Val Single submitter ⚠
- p.Lys217Gln Single submitter ⚠
- p.Lys480Arg Single submitter ⚠
- p.Lys558Glu Single submitter ⚠
- p.Lys564Thr Single submitter ⚠
- p.Met101Val Single submitter ⚠
- p.Met111Leu Single submitter ⚠
- p.Met243Ile Single submitter ⚠
- p.Met285Val Single submitter ⚠
- p.Met294Thr Single submitter ⚠
- p.Met346Thr Single submitter ⚠
- p.Met672Val Single submitter ⚠
- p.Phe316Val Single submitter ⚠
- p.Pro251Leu Single submitter ⚠
- p.Pro282Ser Single submitter ⚠
- p.Pro631Ser Single submitter ⚠
- p.Ser110Asn Single submitter ⚠
- p.Ser20Cys Single submitter ⚠
- p.Ser457Thr Single submitter ⚠
- p.Ser506Ile Single submitter ⚠
- p.Ser603Phe Single submitter ⚠
- p.Thr24Ser Single submitter ⚠
- p.Thr714Ser Single submitter ⚠
- p.Tyr159His Single submitter ⚠
- p.Tyr163His Single submitter ⚠
- p.Tyr315Cys Single submitter ⚠
- p.Tyr355Asp Single submitter ⚠
- p.Tyr429Ser Single submitter ⚠
- p.Val118Ile Single submitter ⚠
- p.Val151Met Single submitter ⚠
- p.Val270Met Single submitter ⚠
- p.Val712Met Single submitter ⚠