CNOT6 — 29 ClinVar variants
All ClinVar germline CNOT6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
29 Uncertain significance
Full CNOT6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CNOT6 p.Ala214Val Uncertain significance Single submitter
- CNOT6 p.Ala32Thr Uncertain significance Single submitter
- CNOT6 p.Arg277Lys Uncertain significance Single submitter
- CNOT6 p.Arg87His Uncertain significance Single submitter
- CNOT6 p.Glu101Val Uncertain significance Single submitter
- CNOT6 p.Gly400Glu Uncertain significance Single submitter
- CNOT6 p.His452Arg Uncertain significance Single submitter
- CNOT6 p.Leu122Phe Uncertain significance Single submitter
- CNOT6 p.Leu348Phe Uncertain significance Single submitter
- CNOT6 p.Lys118Arg Uncertain significance Single submitter
- CNOT6 p.Lys28Arg Uncertain significance Single submitter
- CNOT6 p.Pro2Leu Uncertain significance Single submitter
- CNOT6 p.Ser230Asn Uncertain significance Single submitter
- CNOT6 p.Tyr207His Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- CNOT6 p.Arg12Trp Uncertain significance Single submitter
- CNOT6 p.Arg392Cys Uncertain significance Single submitter
- CNOT6 p.Arg41Lys Uncertain significance Single submitter
- CNOT6 p.Glu22Gly Uncertain significance Single submitter
- CNOT6 p.Glu7Asp Uncertain significance Single submitter
- CNOT6 p.Gly208Ser Uncertain significance Single submitter
- CNOT6 p.Gly349Arg Uncertain significance Single submitter
- CNOT6 p.Gly460Arg Uncertain significance Single submitter
- CNOT6 p.Ile235Val Uncertain significance Single submitter
- CNOT6 p.Ile285Val Uncertain significance Single submitter
- CNOT6 p.Leu394Pro Uncertain significance Single submitter
- CNOT6 p.Met272Val Uncertain significance Single submitter
- CNOT6 p.Ser474Gly Uncertain significance Single submitter
- CNOT6 p.Thr186Ile Uncertain significance Single submitter
- CNOT6 p.Tyr152Cys Uncertain significance Single submitter
All CNOT6 variants
Uncertain significance 29
- p.Ala214Val Single submitter ⚠
- p.Ala32Thr Single submitter ⚠
- p.Arg12Trp Single submitter ⚠
- p.Arg277Lys Single submitter ⚠
- p.Arg392Cys Single submitter ⚠
- p.Arg41Lys Single submitter ⚠
- p.Arg87His Single submitter ⚠
- p.Glu101Val Single submitter ⚠
- p.Glu22Gly Single submitter ⚠
- p.Glu7Asp Single submitter ⚠
- p.Gly208Ser Single submitter ⚠
- p.Gly349Arg Single submitter ⚠
- p.Gly400Glu Single submitter ⚠
- p.Gly460Arg Single submitter ⚠
- p.His452Arg Single submitter ⚠
- p.Ile235Val Single submitter ⚠
- p.Ile285Val Single submitter ⚠
- p.Leu122Phe Single submitter ⚠
- p.Leu348Phe Single submitter ⚠
- p.Leu394Pro Single submitter ⚠
- p.Lys118Arg Single submitter ⚠
- p.Lys28Arg Single submitter ⚠
- p.Met272Val Single submitter ⚠
- p.Pro2Leu Single submitter ⚠
- p.Ser230Asn Single submitter ⚠
- p.Ser474Gly Single submitter ⚠
- p.Thr186Ile Single submitter ⚠
- p.Tyr152Cys Single submitter ⚠
- p.Tyr207His Single submitter ⚠