CNR1 — 46 ClinVar variants
All ClinVar germline CNR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
1 Benign · 9 Likely benign · 36 Uncertain significance
Full CNR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CNR1 p.Ala439Val Uncertain significance Single submitter
- CNR1 p.Ala446Thr Uncertain significance Single submitter
- CNR1 p.Ala64Val Uncertain significance Single submitter
- CNR1 p.Arg145Ser Uncertain significance Single submitter
- CNR1 p.Arg311His Uncertain significance Single submitter
- CNR1 p.Arg409Gln Uncertain significance Single submitter
- CNR1 p.Asp428Val Uncertain significance Single submitter
- CNR1 p.Asp74Gly Uncertain significance Single submitter
- CNR1 p.Gln420Arg Uncertain significance Single submitter
- CNR1 p.Gln59Arg Uncertain significance Single submitter
- CNR1 p.Gln75Glu Uncertain significance Single submitter
- CNR1 p.Glu31Lys Uncertain significance Single submitter
- CNR1 p.Gly157Ser Uncertain significance Single submitter
- CNR1 p.Gly195Arg Uncertain significance Single submitter
- CNR1 p.His406Leu Uncertain significance Single submitter
- CNR1 p.Ile245Val Uncertain significance Single submitter
- CNR1 p.Ile28Asn Uncertain significance Single submitter
- CNR1 p.Ile33Val Uncertain significance Single submitter
- CNR1 p.Ile456Leu Uncertain significance Single submitter
- CNR1 p.Leu374Val Uncertain significance Single submitter
- CNR1 p.Leu41Ser Uncertain significance Single submitter
- CNR1 p.Leu50Ser Uncertain significance Single submitter
- CNR1 p.Leu86Phe Uncertain significance Single submitter
- CNR1 p.Met37Ile Uncertain significance Single submitter
- CNR1 p.Met62Thr Uncertain significance Single submitter
- CNR1 p.Phe13Val Uncertain significance Single submitter
- CNR1 p.Ser429Leu Uncertain significance Single submitter
- CNR1 p.Ser87Pro Uncertain significance Single submitter
- CNR1 p.Val23Met Uncertain significance Single submitter
- CNR1 p.Val291Leu Uncertain significance Single submitter
- CNR1 p.Val351Leu Uncertain significance Single submitter
- CNR1 p.Val442Gly Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All CNR1 variants
Benign 1
- p.His304= Single submitter
Likely benign 9
- p.Ala160= Single submitter
- p.Ile227= Single submitter
- p.Ser87= Single submitter
- p.Thr377= Single submitter
- p.Thr467= Single submitter
- p.Val364= Single submitter
- p.Ala248= No assertion criteria CNR1-related disorder
- p.Ala305= No assertion criteria CNR1-related disorder
- p.Asp10= No assertion criteria CNR1-related disorder
Uncertain significance 36
- p.Ala439Val Single submitter ⚠
- p.Ala446Thr Single submitter ⚠
- p.Ala64Val Single submitter ⚠
- p.Arg145Ser Single submitter ⚠
- p.Arg311His Single submitter ⚠
- p.Arg409Gln Single submitter ⚠
- p.Asp428Val Single submitter ⚠
- p.Asp74Gly Single submitter ⚠
- p.Gln420Arg Single submitter ⚠
- p.Gln59Arg Single submitter ⚠
- p.Gln75Glu Single submitter ⚠
- p.Glu31Lys Single submitter ⚠
- p.Gly157Ser Single submitter ⚠
- p.Gly195Arg Single submitter ⚠
- p.His406Leu Single submitter ⚠
- p.Ile16Ser Single submitter ⚠
- p.Ile245Val Single submitter ⚠
- p.Ile28Asn Single submitter ⚠
- p.Ile33Val Single submitter ⚠
- p.Ile456Leu Single submitter ⚠
- p.Leu164Phe Single submitter ⚠
- p.Leu374Val Single submitter ⚠
- p.Leu41Ser Single submitter ⚠
- p.Leu50Ser Single submitter ⚠
- p.Leu86Phe Single submitter ⚠
- p.Met37Ile Single submitter ⚠
- p.Met62Thr Single submitter ⚠
- p.Phe13Val Single submitter ⚠
- p.Ser429Leu Single submitter ⚠
- p.Ser87Pro Single submitter ⚠
- p.Thr377Ala Single submitter ⚠
- p.Val23Met Single submitter ⚠
- p.Val291Leu Single submitter ⚠
- p.Val351Ala Single submitter ⚠
- p.Val351Leu Single submitter ⚠
- p.Val442Gly Single submitter ⚠