COMMD10 — 35 ClinVar variants
All ClinVar germline COMMD10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
3 Likely benign · 32 Uncertain significance
Full COMMD10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- COMMD10 p.Ala196Thr Uncertain significance Single submitter
- COMMD10 p.Ala5Thr Uncertain significance Single submitter
- COMMD10 p.Arg36Trp Uncertain significance Single submitter
- COMMD10 p.Asn166Lys Uncertain significance Single submitter
- COMMD10 p.Glu192Gly Uncertain significance Single submitter
- COMMD10 p.Glu192Val Uncertain significance Single submitter
- COMMD10 p.Gly163Glu Uncertain significance Single submitter
- COMMD10 p.His181Gln Uncertain significance Single submitter
- COMMD10 p.Ile75Val Uncertain significance Single submitter
- COMMD10 p.Ile8Val Uncertain significance Single submitter
- COMMD10 p.Leu41Pro Uncertain significance Single submitter
- COMMD10 p.Lys105Arg Uncertain significance Single submitter
- COMMD10 p.Met116Val Uncertain significance Single submitter
- COMMD10 p.Met145Val Uncertain significance Single submitter
- COMMD10 p.Met15Thr Uncertain significance Single submitter
- COMMD10 p.Phe77Leu Uncertain significance Single submitter
- COMMD10 p.Tyr188His Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- COMMD10 p.Ala2Pro Uncertain significance Single submitter
- COMMD10 p.Ala90Val Uncertain significance Single submitter
- COMMD10 p.Arg125Gln Uncertain significance Single submitter
- COMMD10 p.Arg125Trp Uncertain significance Single submitter
- COMMD10 p.Asp186Tyr Uncertain significance Single submitter
- COMMD10 p.Asp26His Uncertain significance Single submitter
- COMMD10 p.Asp67Tyr Uncertain significance Single submitter
- COMMD10 p.Gln157Glu Uncertain significance Single submitter
- COMMD10 p.Glu54Val Uncertain significance Single submitter
- COMMD10 p.Glu55Lys Uncertain significance Single submitter
- COMMD10 p.Gly163Arg Uncertain significance Single submitter
- COMMD10 p.Leu134Val Uncertain significance Single submitter
- COMMD10 p.Leu68Val Uncertain significance Single submitter
- COMMD10 p.Lys182Met Uncertain significance Single submitter
- COMMD10 p.Val19Ala Uncertain significance Single submitter
All COMMD10 variants
Likely benign 3
- p.Ala24Glu Single submitter
- p.Ala59Val Single submitter
- p.Pro4Ser Single submitter
Uncertain significance 32
- p.Ala196Thr Single submitter ⚠
- p.Ala2Pro Single submitter ⚠
- p.Ala5Thr Single submitter ⚠
- p.Ala90Val Single submitter ⚠
- p.Arg125Gln Single submitter ⚠
- p.Arg125Trp Single submitter ⚠
- p.Arg36Trp Single submitter ⚠
- p.Asn166Lys Single submitter ⚠
- p.Asp186Tyr Single submitter ⚠
- p.Asp26His Single submitter ⚠
- p.Asp67Tyr Single submitter ⚠
- p.Gln157Glu Single submitter ⚠
- p.Glu192Gly Single submitter ⚠
- p.Glu192Val Single submitter ⚠
- p.Glu54Val Single submitter ⚠
- p.Glu55Lys Single submitter ⚠
- p.Gly163Arg Single submitter ⚠
- p.Gly163Glu Single submitter ⚠
- p.His181Gln Single submitter ⚠
- p.Ile75Val Single submitter ⚠
- p.Ile8Val Single submitter ⚠
- p.Leu134Val Single submitter ⚠
- p.Leu41Pro Single submitter ⚠
- p.Leu68Val Single submitter ⚠
- p.Lys105Arg Single submitter ⚠
- p.Lys182Met Single submitter ⚠
- p.Met116Val Single submitter ⚠
- p.Met145Val Single submitter ⚠
- p.Met15Thr Single submitter ⚠
- p.Phe77Leu Single submitter ⚠
- p.Tyr188His Single submitter ⚠
- p.Val19Ala Single submitter ⚠