COPE — 53 ClinVar variants
All ClinVar germline COPE variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
53 Uncertain significance
Full COPE gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- COPE p.Ala124Thr Uncertain significance Single submitter
- COPE p.Ala139Val Uncertain significance Single submitter
- COPE p.Ala308Thr Uncertain significance Single submitter
- COPE p.Ala59Val Uncertain significance Single submitter
- COPE p.Ala92Thr Uncertain significance Single submitter
- COPE p.Ala9Ser Uncertain significance Single submitter
- COPE p.Arg106Gln Uncertain significance Single submitter
- COPE p.Arg161Cys Uncertain significance Single submitter
- COPE p.Arg231His Uncertain significance Single submitter
- COPE p.Gln303Arg Uncertain significance Single submitter
- COPE p.Glu236Lys Uncertain significance Single submitter
- COPE p.Gly14Glu Uncertain significance Single submitter
- COPE p.His129Tyr Uncertain significance Single submitter
- COPE p.Phe297Leu Uncertain significance Single submitter
- COPE p.Pro8Arg Uncertain significance Single submitter
- COPE p.Val114Leu Uncertain significance Single submitter
- COPE p.Val50Leu Uncertain significance Single submitter
- COPE p.Val54Ile Uncertain significance Single submitter
- COPE p.Val69Phe Uncertain significance Single submitter
Predictors split 34
The independent predictors disagree with each other — read with care.
- COPE p.Ala185Thr Uncertain significance Single submitter
- COPE p.Ala224Thr Uncertain significance Single submitter
- COPE p.Ala25Thr Uncertain significance Single submitter
- COPE p.Ala2Gly Uncertain significance Single submitter
- COPE p.Ala83Ser Uncertain significance Single submitter
- COPE p.Ala9Val Uncertain significance Single submitter
- COPE p.Arg166Gly Uncertain significance Single submitter
- COPE p.Arg166Trp Uncertain significance Single submitter
- COPE p.Arg171Ile Uncertain significance Single submitter
- COPE p.Arg282Gly Uncertain significance Single submitter
- COPE p.Arg299Lys Uncertain significance Single submitter
- COPE p.Arg85Cys Uncertain significance Single submitter
- COPE p.Arg96Trp Uncertain significance Single submitter
- COPE p.Asp130His Uncertain significance Single submitter
- COPE p.Asp144Tyr Uncertain significance Single submitter
- COPE p.Asp160His Uncertain significance Single submitter
- COPE p.Asp71Gly Uncertain significance Single submitter
- COPE p.Leu121Phe Uncertain significance Single submitter
- COPE p.Leu157Val Uncertain significance Single submitter
- COPE p.Leu162Pro Uncertain significance Single submitter
- COPE p.Leu216Arg Uncertain significance Single submitter
- COPE p.Leu216Met Uncertain significance Single submitter
- COPE p.Met108Ile Uncertain significance Single submitter
- COPE p.Met122Thr Uncertain significance Single submitter
- COPE p.Phe119Leu Uncertain significance Single submitter
- COPE p.Pro306Ala Uncertain significance Single submitter
- COPE p.Pro3Leu Uncertain significance Single submitter
- COPE p.Pro8Leu Uncertain significance Single submitter
- COPE p.Ser247Ile Uncertain significance Single submitter
- COPE p.Ser77Leu Uncertain significance Single submitter
- COPE p.Thr152Lys Uncertain significance Single submitter
- COPE p.Tyr90Cys Uncertain significance Single submitter
- COPE p.Val101Met Uncertain significance Single submitter
- COPE p.Val16Ile Uncertain significance Single submitter
All COPE variants
Uncertain significance 53
- p.Ala124Thr Single submitter ⚠
- p.Ala139Val Single submitter ⚠
- p.Ala185Thr Single submitter ⚠
- p.Ala224Thr Single submitter ⚠
- p.Ala25Thr Single submitter ⚠
- p.Ala2Gly Single submitter ⚠
- p.Ala308Thr Single submitter ⚠
- p.Ala59Val Single submitter ⚠
- p.Ala83Ser Single submitter ⚠
- p.Ala92Thr Single submitter ⚠
- p.Ala9Ser Single submitter ⚠
- p.Ala9Val Single submitter ⚠
- p.Arg106Gln Single submitter ⚠
- p.Arg161Cys Single submitter ⚠
- p.Arg166Gly Single submitter ⚠
- p.Arg166Trp Single submitter ⚠
- p.Arg171Ile Single submitter ⚠
- p.Arg231His Single submitter ⚠
- p.Arg282Gly Single submitter ⚠
- p.Arg299Lys Single submitter ⚠
- p.Arg85Cys Single submitter ⚠
- p.Arg96Trp Single submitter ⚠
- p.Asp130His Single submitter ⚠
- p.Asp144Tyr Single submitter ⚠
- p.Asp160His Single submitter ⚠
- p.Asp71Gly Single submitter ⚠
- p.Gln303Arg Single submitter ⚠
- p.Glu236Lys Single submitter ⚠
- p.Gly14Glu Single submitter ⚠
- p.His129Tyr Single submitter ⚠
- p.Leu121Phe Single submitter ⚠
- p.Leu157Val Single submitter ⚠
- p.Leu162Pro Single submitter ⚠
- p.Leu216Arg Single submitter ⚠
- p.Leu216Met Single submitter ⚠
- p.Met108Ile Single submitter ⚠
- p.Met122Thr Single submitter ⚠
- p.Phe119Leu Single submitter ⚠
- p.Phe297Leu Single submitter ⚠
- p.Pro306Ala Single submitter ⚠
- p.Pro3Leu Single submitter ⚠
- p.Pro8Arg Single submitter ⚠
- p.Pro8Leu Single submitter ⚠
- p.Ser247Ile Single submitter ⚠
- p.Ser77Leu Single submitter ⚠
- p.Thr152Lys Single submitter ⚠
- p.Tyr90Cys Single submitter ⚠
- p.Val101Met Single submitter ⚠
- p.Val114Leu Single submitter ⚠
- p.Val16Ile Single submitter ⚠
- p.Val50Leu Single submitter ⚠
- p.Val54Ile Single submitter ⚠
- p.Val69Phe Single submitter ⚠