COPG2 — 25 ClinVar variants
All ClinVar germline COPG2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
25 Uncertain significance
Full COPG2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 10
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- COPG2 p.Arg32Cys Uncertain significance Single submitter
- COPG2 p.Asp207Asn Uncertain significance Single submitter
- COPG2 p.Cys129Tyr Uncertain significance Single submitter
- COPG2 p.Ile190Val Uncertain significance Single submitter
- COPG2 p.Met87Ile Uncertain significance Single submitter
- COPG2 p.Pro123Leu Uncertain significance Single submitter
- COPG2 p.Ser170Asn Uncertain significance Single submitter
- COPG2 p.Thr106Ile Uncertain significance Single submitter
- COPG2 p.Thr114Ala Uncertain significance Single submitter
- COPG2 p.Thr64Met Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- COPG2 p.Ala96Thr Uncertain significance Single submitter
- COPG2 p.Arg130Ser Uncertain significance Single submitter
- COPG2 p.Arg75Gln Uncertain significance Single submitter
- COPG2 p.Asn179Ser Uncertain significance Single submitter
- COPG2 p.Asn189Ser Uncertain significance Single submitter
- COPG2 p.Asn40Thr Uncertain significance Single submitter
- COPG2 p.Asp81Asn Uncertain significance Single submitter
- COPG2 p.Gln138Glu Uncertain significance Single submitter
- COPG2 p.Ile125Leu Uncertain significance Single submitter
- COPG2 p.Ile125Val Uncertain significance Single submitter
- COPG2 p.Ile39Val Uncertain significance Single submitter
- COPG2 p.Ile92Val Uncertain significance Single submitter
- COPG2 p.Ile98Thr Uncertain significance Single submitter
- COPG2 p.Leu160Val Uncertain significance Single submitter
- COPG2 p.Leu48Ile Uncertain significance Single submitter
All COPG2 variants
Uncertain significance 25
- p.Ala96Thr Single submitter ⚠
- p.Arg130Ser Single submitter ⚠
- p.Arg32Cys Single submitter ⚠
- p.Arg75Gln Single submitter ⚠
- p.Asn179Ser Single submitter ⚠
- p.Asn189Ser Single submitter ⚠
- p.Asn40Thr Single submitter ⚠
- p.Asp207Asn Single submitter ⚠
- p.Asp81Asn Single submitter ⚠
- p.Cys129Tyr Single submitter ⚠
- p.Gln138Glu Single submitter ⚠
- p.Ile125Leu Single submitter ⚠
- p.Ile125Val Single submitter ⚠
- p.Ile190Val Single submitter ⚠
- p.Ile39Val Single submitter ⚠
- p.Ile92Val Single submitter ⚠
- p.Ile98Thr Single submitter ⚠
- p.Leu160Val Single submitter ⚠
- p.Leu48Ile Single submitter ⚠
- p.Met87Ile Single submitter ⚠
- p.Pro123Leu Single submitter ⚠
- p.Ser170Asn Single submitter ⚠
- p.Thr106Ile Single submitter ⚠
- p.Thr114Ala Single submitter ⚠
- p.Thr64Met Single submitter ⚠