COQ3 — 52 ClinVar variants
All ClinVar germline COQ3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
4 Likely benign · 48 Uncertain significance
Full COQ3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- COQ3 p.Ala169Pro Uncertain significance Single submitter
- COQ3 p.Arg201Lys Uncertain significance Single submitter
- COQ3 p.Arg29Cys Uncertain significance Single submitter
- COQ3 p.Arg29His Uncertain significance Single submitter
- COQ3 p.Asp175His Uncertain significance Single submitter
- COQ3 p.Cys358Tyr Uncertain significance Single submitter
- COQ3 p.Gln236Arg Uncertain significance Single submitter
- COQ3 p.Gln354Lys Uncertain significance Single submitter
- COQ3 p.Gln41Glu Uncertain significance Single submitter
- COQ3 p.Gln41His Uncertain significance Single submitter
- COQ3 p.Glu214Gly Uncertain significance Single submitter
- COQ3 p.His317Gln Uncertain significance Single submitter
- COQ3 p.Ile253Val Uncertain significance Single submitter
- COQ3 p.Leu167Pro Uncertain significance Single submitter
- COQ3 p.Leu231Ile Uncertain significance Single submitter
- COQ3 p.Phe284Ser Uncertain significance Single submitter
- COQ3 p.Phe53Ser Uncertain significance Single submitter
- COQ3 p.Pro20Leu Uncertain significance Single submitter
- COQ3 p.Ser222Phe Uncertain significance Single submitter
- COQ3 p.Ser267Leu Uncertain significance Single submitter
- COQ3 p.Ser272Asn Uncertain significance Single submitter
- COQ3 p.Ser9Phe Uncertain significance Single submitter
- COQ3 p.Thr212Ala Uncertain significance Single submitter
- COQ3 p.Thr212Asn Uncertain significance Single submitter
- COQ3 p.Thr251Asn Uncertain significance Single submitter
- COQ3 p.Thr25Lys Uncertain significance Single submitter
- COQ3 p.Thr289Ala Uncertain significance Single submitter
- COQ3 p.Trp318Arg Uncertain significance Single submitter
- COQ3 p.Tyr37His Uncertain significance Single submitter
- COQ3 p.Val301Ile Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- COQ3 p.Arg197Ile Uncertain significance Single submitter
- COQ3 p.Asp109Val Uncertain significance Single submitter
- COQ3 p.Asp191Asn Uncertain significance Single submitter
- COQ3 p.Glu211Ala Uncertain significance Single submitter
- COQ3 p.Gly245Arg Uncertain significance Single submitter
- COQ3 p.Leu18Arg Uncertain significance Single submitter
- COQ3 p.Lys134Thr Uncertain significance Single submitter
- COQ3 p.Pro311Ser Uncertain significance Single submitter
- COQ3 p.Pro311Thr Uncertain significance Single submitter
- COQ3 p.Ser286Leu Uncertain significance Single submitter
- COQ3 p.Ser296Leu Uncertain significance Single submitter
- COQ3 p.Ser313Leu Uncertain significance Single submitter
- COQ3 p.Ser33Phe Uncertain significance Single submitter
- COQ3 p.Ser69Phe Uncertain significance Single submitter
- COQ3 p.Thr303Ile Uncertain significance Single submitter
- COQ3 p.Val202Met Likely benign Single submitter
- COQ3 p.Val241Ala Uncertain significance Single submitter
- COQ3 p.Val304Ala Uncertain significance Single submitter
- COQ3 p.Val363Met Uncertain significance Single submitter
All COQ3 variants
Likely benign 4
- p.Arg334Gly Single submitter
- p.Asn180= Single submitter
- p.Asn54Ser Single submitter
- p.Val202Met Single submitter ⚠
Uncertain significance 48
- p.Ala169Pro Single submitter ⚠
- p.Arg197Ile Single submitter ⚠
- p.Arg201Lys Single submitter ⚠
- p.Arg29Cys Single submitter ⚠
- p.Arg29His Single submitter ⚠
- p.Asp109Val Single submitter ⚠
- p.Asp175His Single submitter ⚠
- p.Asp191Asn Single submitter ⚠
- p.Cys358Tyr Single submitter ⚠
- p.Gln236Arg Single submitter ⚠
- p.Gln354Lys Single submitter ⚠
- p.Gln41Glu Single submitter ⚠
- p.Gln41His Single submitter ⚠
- p.Glu211Ala Single submitter ⚠
- p.Glu214Gly Single submitter ⚠
- p.Gly245Arg Single submitter ⚠
- p.His317Gln Single submitter ⚠
- p.Ile253Val Single submitter ⚠
- p.Leu167Pro Single submitter ⚠
- p.Leu18Arg Single submitter ⚠
- p.Leu231Ile Single submitter ⚠
- p.Lys134Thr Single submitter ⚠
- p.Phe284Ser Single submitter ⚠
- p.Phe53Ser Single submitter ⚠
- p.Pro20Leu Single submitter ⚠
- p.Pro311Ser Single submitter ⚠
- p.Pro311Thr Single submitter ⚠
- p.Ser222Phe Single submitter ⚠
- p.Ser267Leu Single submitter ⚠
- p.Ser272Asn Single submitter ⚠
- p.Ser286Leu Single submitter ⚠
- p.Ser296Leu Single submitter ⚠
- p.Ser313Leu Single submitter ⚠
- p.Ser33Phe Single submitter ⚠
- p.Ser69Phe Single submitter ⚠
- p.Ser9Phe Single submitter ⚠
- p.Thr212Ala Single submitter ⚠
- p.Thr212Asn Single submitter ⚠
- p.Thr251Asn Single submitter ⚠
- p.Thr25Lys Single submitter ⚠
- p.Thr289Ala Single submitter ⚠
- p.Thr303Ile Single submitter ⚠
- p.Trp318Arg Single submitter ⚠
- p.Tyr37His Single submitter ⚠
- p.Val241Ala Single submitter ⚠
- p.Val301Ile Single submitter ⚠
- p.Val304Ala Single submitter ⚠
- p.Val363Met Single submitter ⚠