CORO1C — 39 ClinVar variants
All ClinVar germline CORO1C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
39 Uncertain significance
Full CORO1C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CORO1C p.Ala371Ser Uncertain significance Single submitter
- CORO1C p.Arg143Cys Uncertain significance Single submitter
- CORO1C p.Arg28Trp Uncertain significance Single submitter
- CORO1C p.Asn113Asp Uncertain significance Single submitter
- CORO1C p.Asn20Ser Uncertain significance Single submitter
- CORO1C p.Asn231Ser Uncertain significance Single submitter
- CORO1C p.Asn457Lys Uncertain significance Single submitter
- CORO1C p.Asp384Glu Uncertain significance Single submitter
- CORO1C p.Asp421Glu Uncertain significance Single submitter
- CORO1C p.Gln206Glu Uncertain significance Single submitter
- CORO1C p.Glu376Asp Uncertain significance Single submitter
- CORO1C p.Gly54Trp Uncertain significance Single submitter
- CORO1C p.His173Tyr Uncertain significance Single submitter
- CORO1C p.His392Asp Uncertain significance Single submitter
- CORO1C p.Ile279Val Uncertain significance Single submitter
- CORO1C p.Ile472Met Uncertain significance Single submitter
- CORO1C p.Lys406Arg Uncertain significance Single submitter
- CORO1C p.Pro300Leu Uncertain significance Single submitter
- CORO1C p.Pro426Leu Uncertain significance Single submitter
- CORO1C p.Ser181Arg Uncertain significance Single submitter
- CORO1C p.Thr415Ser Uncertain significance Single submitter
- CORO1C p.Thr432Met Uncertain significance Single submitter
- CORO1C p.Tyr24His Uncertain significance Single submitter
- CORO1C p.Tyr273Cys Uncertain significance Single submitter
- CORO1C p.Val435Met Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- CORO1C p.Ala142Val Uncertain significance Single submitter
- CORO1C p.Arg184Trp Uncertain significance Single submitter
- CORO1C p.Asn144Ser Uncertain significance Single submitter
- CORO1C p.Glu242Gln Uncertain significance Single submitter
- CORO1C p.Lys407Glu Uncertain significance Single submitter
- CORO1C p.Met172Ile Uncertain significance Single submitter
- CORO1C p.Met222Val Uncertain significance Single submitter
- CORO1C p.Met240Val Uncertain significance Single submitter
- CORO1C p.Phe308Leu Uncertain significance Single submitter
- CORO1C p.Pro250Ala Uncertain significance Single submitter
- CORO1C p.Thr141Ala Uncertain significance Single submitter
- CORO1C p.Thr307Ala Uncertain significance Single submitter
- CORO1C p.Thr80Arg Uncertain significance Single submitter
- CORO1C p.Val404Ala Uncertain significance Single submitter
All CORO1C variants
Uncertain significance 39
- p.Ala142Val Single submitter ⚠
- p.Ala371Ser Single submitter ⚠
- p.Arg143Cys Single submitter ⚠
- p.Arg184Trp Single submitter ⚠
- p.Arg28Trp Single submitter ⚠
- p.Asn113Asp Single submitter ⚠
- p.Asn144Ser Single submitter ⚠
- p.Asn20Ser Single submitter ⚠
- p.Asn231Ser Single submitter ⚠
- p.Asn457Lys Single submitter ⚠
- p.Asp384Glu Single submitter ⚠
- p.Asp421Glu Single submitter ⚠
- p.Gln206Glu Single submitter ⚠
- p.Glu242Gln Single submitter ⚠
- p.Glu376Asp Single submitter ⚠
- p.Gly54Trp Single submitter ⚠
- p.His173Tyr Single submitter ⚠
- p.His392Asp Single submitter ⚠
- p.Ile279Val Single submitter ⚠
- p.Ile472Met Single submitter ⚠
- p.Lys406Arg Single submitter ⚠
- p.Lys407Glu Single submitter ⚠
- p.Met172Ile Single submitter ⚠
- p.Met222Val Single submitter ⚠
- p.Met240Val Single submitter ⚠
- p.Phe308Leu Single submitter ⚠
- p.Pro250Ala Single submitter ⚠
- p.Pro300Leu Single submitter ⚠
- p.Pro426Leu Single submitter ⚠
- p.Ser181Arg Single submitter ⚠
- p.Thr141Ala Single submitter ⚠
- p.Thr307Ala Single submitter ⚠
- p.Thr415Ser Single submitter ⚠
- p.Thr432Met Single submitter ⚠
- p.Thr80Arg Single submitter ⚠
- p.Tyr24His Single submitter ⚠
- p.Tyr273Cys Single submitter ⚠
- p.Val404Ala Single submitter ⚠
- p.Val435Met Single submitter ⚠