CORO2A — 93 ClinVar variants
All ClinVar germline CORO2A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 89 flagged for review →
5 Likely benign · 88 Uncertain significance
Full CORO2A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 89
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CORO2A p.Ala105Asp Uncertain significance Single submitter
- CORO2A p.Ala132Thr Uncertain significance Single submitter
- CORO2A p.Ala145Thr Uncertain significance Single submitter
- CORO2A p.Ala218Thr Uncertain significance Single submitter
-
CORO2A p.Arg133His
Uncertain significance
Single submitter
myoepithelial tumor
- CORO2A p.Arg13Cys Uncertain significance Single submitter
- CORO2A p.Arg13His Uncertain significance Single submitter
- CORO2A p.Arg13Leu Uncertain significance Single submitter
- CORO2A p.Arg13Ser Uncertain significance Single submitter
- CORO2A p.Arg205Trp Uncertain significance Single submitter
- CORO2A p.Arg248Trp Uncertain significance Single submitter
- CORO2A p.Arg339His Uncertain significance Single submitter
- CORO2A p.Arg504Gln Uncertain significance Single submitter
- CORO2A p.Asp154Gly Uncertain significance Single submitter
- CORO2A p.Asp281Ala Uncertain significance Single submitter
- CORO2A p.Asp303Glu Uncertain significance Single submitter
- CORO2A p.Cys335Gly Uncertain significance Single submitter
- CORO2A p.Gln507Leu Uncertain significance Single submitter
- CORO2A p.Glu336Lys Uncertain significance Single submitter
- CORO2A p.Glu473Lys Uncertain significance Single submitter
- CORO2A p.Gly289Arg Uncertain significance Single submitter
- CORO2A p.Gly80Arg Uncertain significance Single submitter
- CORO2A p.His131Gln Uncertain significance Single submitter
- CORO2A p.Ile31Val Uncertain significance Single submitter
- CORO2A p.Leu229Pro Uncertain significance Single submitter
- CORO2A p.Leu444Pro Uncertain significance Single submitter
- CORO2A p.Lys200Glu Uncertain significance Single submitter
- CORO2A p.Lys22Glu Uncertain significance Single submitter
- CORO2A p.Lys304Arg Uncertain significance Single submitter
- CORO2A p.Lys462Asn Uncertain significance Single submitter
- CORO2A p.Lys509Arg Uncertain significance Single submitter
- CORO2A p.Met186Thr Uncertain significance Single submitter
- CORO2A p.Phe40Leu Uncertain significance Single submitter
- CORO2A p.Pro421Thr Uncertain significance Single submitter
- CORO2A p.Pro476Leu Uncertain significance Single submitter
- CORO2A p.Thr52Ile Uncertain significance Single submitter
- CORO2A p.Trp253Arg Uncertain significance Single submitter
- CORO2A p.Trp3Leu Uncertain significance Single submitter
- CORO2A p.Tyr369His Uncertain significance Single submitter
- CORO2A p.Val15Ala Uncertain significance Single submitter
- CORO2A p.Val287Met Uncertain significance Single submitter
- CORO2A p.Val357Met Uncertain significance Single submitter
- CORO2A p.Val43Leu Uncertain significance Single submitter
Predictors split 46
The independent predictors disagree with each other — read with care.
- CORO2A p.Ala144Thr Uncertain significance Single submitter
- CORO2A p.Ala280Thr Uncertain significance Single submitter
- CORO2A p.Ala59Ser Uncertain significance Single submitter
- CORO2A p.Ala59Thr Uncertain significance Single submitter
- CORO2A p.Arg210Gln Uncertain significance Single submitter
- CORO2A p.Arg224Trp Uncertain significance Single submitter
- CORO2A p.Arg296His Uncertain significance Single submitter
- CORO2A p.Arg314Cys Uncertain significance Single submitter
- CORO2A p.Arg314His Uncertain significance Single submitter
- CORO2A p.Arg33Cys Uncertain significance Single submitter
- CORO2A p.Arg390Gln Likely benign Single submitter
- CORO2A p.Arg425Trp Uncertain significance Single submitter
- CORO2A p.Arg498Trp Uncertain significance Single submitter
- CORO2A p.Arg519Gln Uncertain significance Single submitter
- CORO2A p.Asn257Tyr Uncertain significance Single submitter
- CORO2A p.Asp266Asn Uncertain significance Single submitter
- CORO2A p.Asp27Asn Uncertain significance Single submitter
- CORO2A p.Asp27His Uncertain significance Single submitter
- CORO2A p.Asp303Asn Uncertain significance Single submitter
- CORO2A p.Asp303Gly Uncertain significance Single submitter
- CORO2A p.Asp72Asn Uncertain significance Single submitter
- CORO2A p.Gln503Lys Uncertain significance Single submitter
- CORO2A p.Glu166Lys Uncertain significance Single submitter
- CORO2A p.Glu480Asp Uncertain significance Single submitter
- CORO2A p.Gly232Arg Uncertain significance Single submitter
- CORO2A p.Gly387Arg Uncertain significance Single submitter
- CORO2A p.Gly83Ser Uncertain significance Single submitter
- CORO2A p.Leu394Val Uncertain significance Single submitter
- CORO2A p.Leu497Ile Uncertain significance Single submitter
- CORO2A p.Lys200Arg Uncertain significance Single submitter
- CORO2A p.Lys22Gln Uncertain significance Single submitter
- CORO2A p.Lys235Glu Uncertain significance Single submitter
- CORO2A p.Pro305Arg Uncertain significance Single submitter
- CORO2A p.Pro406Thr Uncertain significance Single submitter
- CORO2A p.Pro64Thr Uncertain significance Single submitter
- CORO2A p.Pro73Thr Uncertain significance Single submitter
- CORO2A p.Ser193Gly Uncertain significance Single submitter
- CORO2A p.Thr122Met Uncertain significance Single submitter
- CORO2A p.Thr175Met Uncertain significance Single submitter
- CORO2A p.Thr242Ile Uncertain significance Single submitter
- CORO2A p.Val135Ile Uncertain significance Single submitter
- CORO2A p.Val138Met Uncertain significance Single submitter
- CORO2A p.Val29Met Uncertain significance Single submitter
- CORO2A p.Val35Ile Uncertain significance Single submitter
- CORO2A p.Val62Ile Uncertain significance Single submitter
- CORO2A p.Val85Ile Uncertain significance Single submitter
All CORO2A variants
Likely benign 5
- p.Ala302Thr Single submitter
- p.Arg390Gln Single submitter ⚠
- p.Pro45= Single submitter
- p.Val206Ile Single submitter
- p.Val471Ile Single submitter
Uncertain significance 88
- p.Ala105Asp Single submitter ⚠
- p.Ala132Thr Single submitter ⚠
- p.Ala144Thr Single submitter ⚠
- p.Ala145Thr Single submitter ⚠
- p.Ala218Thr Single submitter ⚠
- p.Ala280Thr Single submitter ⚠
- p.Ala59Ser Single submitter ⚠
- p.Ala59Thr Single submitter ⚠
- p.Arg133His Single submitter myoepithelial tumor ⚠
- p.Arg13Cys Single submitter ⚠
- p.Arg13His Single submitter ⚠
- p.Arg13Leu Single submitter ⚠
- p.Arg13Ser Single submitter ⚠
- p.Arg205Trp Single submitter ⚠
- p.Arg210Gln Single submitter ⚠
- p.Arg224Trp Single submitter ⚠
- p.Arg248Trp Single submitter ⚠
- p.Arg296His Single submitter ⚠
- p.Arg314Cys Single submitter ⚠
- p.Arg314His Single submitter ⚠
- p.Arg339His Single submitter ⚠
- p.Arg33Cys Single submitter ⚠
- p.Arg425Trp Single submitter ⚠
- p.Arg498Trp Single submitter ⚠
- p.Arg504Gln Single submitter ⚠
- p.Arg519Gln Single submitter ⚠
- p.Asn257Tyr Single submitter ⚠
- p.Asp154Gly Single submitter ⚠
- p.Asp266Asn Single submitter ⚠
- p.Asp27Asn Single submitter ⚠
- p.Asp27His Single submitter ⚠
- p.Asp281Ala Single submitter ⚠
- p.Asp303Asn Single submitter ⚠
- p.Asp303Glu Single submitter ⚠
- p.Asp303Gly Single submitter ⚠
- p.Asp72Asn Single submitter ⚠
- p.Cys335Gly Single submitter ⚠
- p.Gln503Lys Single submitter ⚠
- p.Gln507Leu Single submitter ⚠
- p.Glu166Lys Single submitter ⚠
- p.Glu336Lys Single submitter ⚠
- p.Glu473Lys Single submitter ⚠
- p.Glu480Asp Single submitter ⚠
- p.Gly232Arg Single submitter ⚠
- p.Gly289Arg Single submitter ⚠
- p.Gly387Arg Single submitter ⚠
- p.Gly80Arg Single submitter ⚠
- p.Gly83Ser Single submitter ⚠
- p.His131Gln Single submitter ⚠
- p.Ile31Val Single submitter ⚠
- p.Leu229Pro Single submitter ⚠
- p.Leu394Val Single submitter ⚠
- p.Leu444Pro Single submitter ⚠
- p.Leu497Ile Single submitter ⚠
- p.Lys200Arg Single submitter ⚠
- p.Lys200Glu Single submitter ⚠
- p.Lys22Gln Single submitter ⚠
- p.Lys22Glu Single submitter ⚠
- p.Lys235Glu Single submitter ⚠
- p.Lys304Arg Single submitter ⚠
- p.Lys462Asn Single submitter ⚠
- p.Lys509Arg Single submitter ⚠
- p.Met186Thr Single submitter ⚠
- p.Phe40Leu Single submitter ⚠
- p.Pro305Arg Single submitter ⚠
- p.Pro406Thr Single submitter ⚠
- p.Pro421Thr Single submitter ⚠
- p.Pro476Leu Single submitter ⚠
- p.Pro64Thr Single submitter ⚠
- p.Pro73Thr Single submitter ⚠
- p.Ser193Gly Single submitter ⚠
- p.Thr122Met Single submitter ⚠
- p.Thr175Met Single submitter ⚠
- p.Thr242Ile Single submitter ⚠
- p.Thr52Ile Single submitter ⚠
- p.Trp253Arg Single submitter ⚠
- p.Trp3Leu Single submitter ⚠
- p.Tyr369His Single submitter ⚠
- p.Val135Ile Single submitter ⚠
- p.Val138Met Single submitter ⚠
- p.Val15Ala Single submitter ⚠
- p.Val287Met Single submitter ⚠
- p.Val29Met Single submitter ⚠
- p.Val357Met Single submitter ⚠
- p.Val35Ile Single submitter ⚠
- p.Val43Leu Single submitter ⚠
- p.Val62Ile Single submitter ⚠
- p.Val85Ile Single submitter ⚠