CORO2B — 59 ClinVar variants
All ClinVar germline CORO2B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
3 Likely benign · 56 Uncertain significance
Full CORO2B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CORO2B p.Ala334Val Uncertain significance Single submitter
- CORO2B p.Ala60Thr Uncertain significance Single submitter
- CORO2B p.Arg124Gln Uncertain significance Single submitter
- CORO2B p.Arg244Thr Uncertain significance Single submitter
- CORO2B p.Arg359Gln Uncertain significance Single submitter
- CORO2B p.Arg440Gln Uncertain significance Single submitter
- CORO2B p.Arg451Pro Uncertain significance Single submitter
- CORO2B p.Arg462His Uncertain significance Single submitter
- CORO2B p.Arg464Gln Uncertain significance Single submitter
- CORO2B p.Asn150Thr Uncertain significance Single submitter
- CORO2B p.Asn479Ile Uncertain significance Single submitter
- CORO2B p.Asp279Tyr Uncertain significance Single submitter
- CORO2B p.Asp32Glu Uncertain significance Single submitter
- CORO2B p.Asp425Gly Uncertain significance Single submitter
- CORO2B p.Cys30Tyr Uncertain significance Single submitter
- CORO2B p.Gly120Cys Uncertain significance Single submitter
- CORO2B p.Gly121Arg Uncertain significance Single submitter
- CORO2B p.Gly241Arg Uncertain significance Single submitter
- CORO2B p.His146Gln Uncertain significance Single submitter
- CORO2B p.Ile263Phe Uncertain significance Single submitter
- CORO2B p.Ile413Val Uncertain significance Single submitter
- CORO2B p.Leu237Ile Uncertain significance Single submitter
- CORO2B p.Met260Leu Uncertain significance Single submitter
- CORO2B p.Met311Thr Uncertain significance Single submitter
- CORO2B p.Met395Ile Uncertain significance Single submitter
- CORO2B p.Met441Ile Uncertain significance Single submitter
- CORO2B p.Phe409Val Uncertain significance Single submitter
- CORO2B p.Pro477Thr Uncertain significance Single submitter
- CORO2B p.Ser111Leu Uncertain significance Single submitter
- CORO2B p.Ser418Arg Uncertain significance Single submitter
- CORO2B p.Ser476Gly Uncertain significance Single submitter
- CORO2B p.Thr180Met Uncertain significance Single submitter
- CORO2B p.Trp115Leu Uncertain significance Single submitter
- CORO2B p.Trp145Cys Uncertain significance Single submitter
- CORO2B p.Val56Ile Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- CORO2B p.Arg13His Uncertain significance Single submitter
- CORO2B p.Arg213His Uncertain significance Single submitter
- CORO2B p.Arg227Gln Uncertain significance Single submitter
- CORO2B p.Arg236Gln Uncertain significance Single submitter
- CORO2B p.Arg444Trp Uncertain significance Single submitter
- CORO2B p.Arg464Trp Uncertain significance Single submitter
- CORO2B p.Arg51His Uncertain significance Single submitter
- CORO2B p.Arg9His Uncertain significance Single submitter
- CORO2B p.Glu119Lys Uncertain significance Single submitter
- CORO2B p.Glu399Gly Uncertain significance Single submitter
- CORO2B p.Glu77Ala Uncertain significance Single submitter
- CORO2B p.Gly386Arg Uncertain significance Single submitter
- CORO2B p.Gly387Ser Uncertain significance Single submitter
- CORO2B p.Ile102Thr Uncertain significance Single submitter
- CORO2B p.Ile350Met Uncertain significance Single submitter
- CORO2B p.Leu194Gln Likely benign Single submitter
- CORO2B p.Lys342Arg Uncertain significance Single submitter
- CORO2B p.Lys94Arg Uncertain significance Single submitter
- CORO2B p.Met126Val Uncertain significance Single submitter
- CORO2B p.Pro10Leu Uncertain significance Single submitter
- CORO2B p.Tyr401Cys Uncertain significance Single submitter
- CORO2B p.Val67Ile Uncertain significance Single submitter
All CORO2B variants
Likely benign 3
- p.Gly62= Single submitter
- p.Leu194Gln Single submitter ⚠
- p.Thr180= Single submitter
Uncertain significance 56
- p.Ala334Val Single submitter ⚠
- p.Ala60Thr Single submitter ⚠
- p.Arg124Gln Single submitter ⚠
- p.Arg13His Single submitter ⚠
- p.Arg213His Single submitter ⚠
- p.Arg227Gln Single submitter ⚠
- p.Arg236Gln Single submitter ⚠
- p.Arg244Thr Single submitter ⚠
- p.Arg359Gln Single submitter ⚠
- p.Arg440Gln Single submitter ⚠
- p.Arg444Trp Single submitter ⚠
- p.Arg451Pro Single submitter ⚠
- p.Arg462His Single submitter ⚠
- p.Arg464Gln Single submitter ⚠
- p.Arg464Trp Single submitter ⚠
- p.Arg51His Single submitter ⚠
- p.Arg9His Single submitter ⚠
- p.Asn150Thr Single submitter ⚠
- p.Asn479Ile Single submitter ⚠
- p.Asp279Tyr Single submitter ⚠
- p.Asp32Glu Single submitter ⚠
- p.Asp425Gly Single submitter ⚠
- p.Cys30Tyr Single submitter ⚠
- p.Glu119Lys Single submitter ⚠
- p.Glu399Gly Single submitter ⚠
- p.Glu77Ala Single submitter ⚠
- p.Gly120Cys Single submitter ⚠
- p.Gly121Arg Single submitter ⚠
- p.Gly241Arg Single submitter ⚠
- p.Gly386Arg Single submitter ⚠
- p.Gly387Ser Single submitter ⚠
- p.His146Gln Single submitter ⚠
- p.Ile102Thr Single submitter ⚠
- p.Ile263Phe Single submitter ⚠
- p.Ile350Met Single submitter ⚠
- p.Ile413Val Single submitter ⚠
- p.Leu237Ile Single submitter ⚠
- p.Lys342Arg Single submitter ⚠
- p.Lys94Arg Single submitter ⚠
- p.Met126Val Single submitter ⚠
- p.Met260Leu Single submitter ⚠
- p.Met311Thr Single submitter ⚠
- p.Met395Ile Single submitter ⚠
- p.Met441Ile Single submitter ⚠
- p.Phe409Val Single submitter ⚠
- p.Pro10Leu Single submitter ⚠
- p.Pro477Thr Single submitter ⚠
- p.Ser111Leu Single submitter ⚠
- p.Ser418Arg Single submitter ⚠
- p.Ser476Gly Single submitter ⚠
- p.Thr180Met Single submitter ⚠
- p.Trp115Leu Single submitter ⚠
- p.Trp145Cys Single submitter ⚠
- p.Tyr401Cys Single submitter ⚠
- p.Val56Ile Single submitter ⚠
- p.Val67Ile Single submitter ⚠