CPLX3 — 25 ClinVar variants
All ClinVar germline CPLX3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
25 Uncertain significance
Full CPLX3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CPLX3 p.Arg103Gln Uncertain significance Single submitter
- CPLX3 p.Arg58Trp Uncertain significance Single submitter
- CPLX3 p.Arg69Trp Uncertain significance Single submitter
- CPLX3 p.Arg77Gln Uncertain significance Single submitter
- CPLX3 p.Arg81Gln Uncertain significance Single submitter
- CPLX3 p.Asp59Gly Uncertain significance Single submitter
- CPLX3 p.Asp98Asn Uncertain significance Single submitter
- CPLX3 p.Asp98Glu Uncertain significance Single submitter
- CPLX3 p.Glu110Lys Uncertain significance Single submitter
- CPLX3 p.Gly11Ser Uncertain significance Single submitter
- CPLX3 p.Ile92Thr Uncertain significance Single submitter
- CPLX3 p.Ile92Val Uncertain significance Single submitter
- CPLX3 p.Lys149Gln Uncertain significance Single submitter
- CPLX3 p.Lys79Thr Uncertain significance Single submitter
- CPLX3 p.Pro102Thr Uncertain significance Single submitter
- CPLX3 p.Thr71Ala Uncertain significance Single submitter
- CPLX3 p.Tyr80Cys Uncertain significance Single submitter
- CPLX3 p.Val52Leu Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CPLX3 p.Arg103Trp Uncertain significance Single submitter
- CPLX3 p.Arg81Trp Uncertain significance Single submitter
- CPLX3 p.Asn85Ser Uncertain significance Single submitter
- CPLX3 p.Gln142His Uncertain significance Single submitter
- CPLX3 p.Leu129Arg Uncertain significance Single submitter
- CPLX3 p.Met39Val Uncertain significance Single submitter
- CPLX3 p.Val99Met Uncertain significance Single submitter
All CPLX3 variants
Uncertain significance 25
- p.Arg103Gln Single submitter ⚠
- p.Arg103Trp Single submitter ⚠
- p.Arg58Trp Single submitter ⚠
- p.Arg69Trp Single submitter ⚠
- p.Arg77Gln Single submitter ⚠
- p.Arg81Gln Single submitter ⚠
- p.Arg81Trp Single submitter ⚠
- p.Asn85Ser Single submitter ⚠
- p.Asp59Gly Single submitter ⚠
- p.Asp98Asn Single submitter ⚠
- p.Asp98Glu Single submitter ⚠
- p.Gln142His Single submitter ⚠
- p.Glu110Lys Single submitter ⚠
- p.Gly11Ser Single submitter ⚠
- p.Ile92Thr Single submitter ⚠
- p.Ile92Val Single submitter ⚠
- p.Leu129Arg Single submitter ⚠
- p.Lys149Gln Single submitter ⚠
- p.Lys79Thr Single submitter ⚠
- p.Met39Val Single submitter ⚠
- p.Pro102Thr Single submitter ⚠
- p.Thr71Ala Single submitter ⚠
- p.Tyr80Cys Single submitter ⚠
- p.Val52Leu Single submitter ⚠
- p.Val99Met Single submitter ⚠