CPLX4 — 16 ClinVar variants
All ClinVar germline CPLX4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 16 flagged for review →
16 Uncertain significance
Full CPLX4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 16
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CPLX4 p.Asp119Asn Uncertain significance Single submitter
- CPLX4 p.Asp60Glu Uncertain significance Single submitter
- CPLX4 p.Ile138Thr Uncertain significance Single submitter
- CPLX4 p.Ile138Val Uncertain significance Single submitter
- CPLX4 p.Ile53Val Uncertain significance Single submitter
- CPLX4 p.Met8Lys Uncertain significance Single submitter
- CPLX4 p.Tyr48His Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- CPLX4 p.Ala153Thr Uncertain significance Single submitter
- CPLX4 p.Ala35Val Uncertain significance Single submitter
- CPLX4 p.Ala36Gly Uncertain significance Single submitter
- CPLX4 p.Ala62Ser Uncertain significance Single submitter
- CPLX4 p.Arg107Trp Uncertain significance Single submitter
- CPLX4 p.Gln12Lys Uncertain significance Single submitter
- CPLX4 p.His76Leu Uncertain significance Single submitter
- CPLX4 p.Leu77Phe Uncertain significance Single submitter
- CPLX4 p.Met109Ile Uncertain significance Single submitter
All CPLX4 variants
Uncertain significance 16
- p.Ala153Thr Single submitter ⚠
- p.Ala35Val Single submitter ⚠
- p.Ala36Gly Single submitter ⚠
- p.Ala62Ser Single submitter ⚠
- p.Arg107Trp Single submitter ⚠
- p.Asp119Asn Single submitter ⚠
- p.Asp60Glu Single submitter ⚠
- p.Gln12Lys Single submitter ⚠
- p.His76Leu Single submitter ⚠
- p.Ile138Thr Single submitter ⚠
- p.Ile138Val Single submitter ⚠
- p.Ile53Val Single submitter ⚠
- p.Leu77Phe Single submitter ⚠
- p.Met109Ile Single submitter ⚠
- p.Met8Lys Single submitter ⚠
- p.Tyr48His Single submitter ⚠