CRACR2A — 141 ClinVar variants
All ClinVar germline CRACR2A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 116 flagged for review →
19 Benign · 8 Likely benign · 114 Uncertain significance
Full CRACR2A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 116
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 60
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRACR2A p.Ala211Thr Uncertain significance Single submitter
- CRACR2A p.Ala340Val Uncertain significance Single submitter
- CRACR2A p.Ala392Ser Uncertain significance Single submitter
- CRACR2A p.Ala646Ser Uncertain significance Single submitter
- CRACR2A p.Ala703Thr Uncertain significance Single submitter
- CRACR2A p.Ala71Ser Uncertain significance Single submitter
- CRACR2A p.Ala71Thr Uncertain significance Single submitter
- CRACR2A p.Arg135Cys Uncertain significance Single submitter
- CRACR2A p.Arg419Thr Uncertain significance Single submitter
- CRACR2A p.Arg466Gln Uncertain significance Single submitter
- CRACR2A p.Arg469His Uncertain significance Single submitter
- CRACR2A p.Arg523Gln Uncertain significance Single submitter
- CRACR2A p.Arg569Gln Uncertain significance Single submitter
- CRACR2A p.Arg583His Uncertain significance Single submitter
- CRACR2A p.Arg637Gln Uncertain significance Single submitter
- CRACR2A p.Asn390Ser Uncertain significance Single submitter
- CRACR2A p.Asp148Val Uncertain significance Single submitter
- CRACR2A p.Asp151Asn Uncertain significance Single submitter
- CRACR2A p.Asp502Glu Uncertain significance Single submitter
- CRACR2A p.Asp63Glu Uncertain significance Single submitter
- CRACR2A p.Gln243Pro Uncertain significance Single submitter
- CRACR2A p.Gln612Glu Uncertain significance Single submitter
- CRACR2A p.Glu108Lys Uncertain significance Single submitter
- CRACR2A p.Glu108Val Uncertain significance Single submitter
- CRACR2A p.Glu667Gln Uncertain significance Single submitter
- CRACR2A p.Gly25Ala Uncertain significance Single submitter
- CRACR2A p.Gly461Glu Uncertain significance Single submitter
- CRACR2A p.Gly47Asp Uncertain significance Single submitter
- CRACR2A p.Gly524Glu Uncertain significance Single submitter
- CRACR2A p.Gly673Arg Uncertain significance Single submitter
- CRACR2A p.Gly721Ser Uncertain significance Single submitter
- CRACR2A p.His299Leu Uncertain significance Single submitter
- CRACR2A p.Ile412Thr Uncertain significance Single submitter
- CRACR2A p.Ile683Leu Uncertain significance Single submitter
- CRACR2A p.Leu104Met Uncertain significance Single submitter
- CRACR2A p.Leu682Gln Uncertain significance Single submitter
- CRACR2A p.Leu86Pro Uncertain significance Single submitter
- CRACR2A p.Lys171Asn Uncertain significance Single submitter
- CRACR2A p.Lys394Asn Uncertain significance Single submitter
- CRACR2A p.Met164Leu Uncertain significance Single submitter
- CRACR2A p.Phe570Leu Uncertain significance Single submitter
- CRACR2A p.Pro447Arg Uncertain significance Single submitter
- CRACR2A p.Pro463Leu Uncertain significance Single submitter
- CRACR2A p.Pro465Ala Uncertain significance Single submitter
- CRACR2A p.Pro465Arg Uncertain significance Single submitter
- CRACR2A p.Pro480Leu Uncertain significance Single submitter
- CRACR2A p.Pro510Leu Uncertain significance Single submitter
- CRACR2A p.Pro513Leu Uncertain significance Single submitter
- CRACR2A p.Pro519Leu Uncertain significance Single submitter
- CRACR2A p.Ser554Phe Uncertain significance Single submitter
- CRACR2A p.Thr111Ser Uncertain significance Single submitter
- CRACR2A p.Thr449Arg Uncertain significance Single submitter
- CRACR2A p.Thr455Ser Uncertain significance Single submitter
- CRACR2A p.Thr518Ala Uncertain significance Single submitter
- CRACR2A p.Thr601Lys Uncertain significance Single submitter
- CRACR2A p.Tyr141Cys Uncertain significance Single submitter
- CRACR2A p.Tyr464His Uncertain significance Single submitter
- CRACR2A p.Tyr607His Uncertain significance Single submitter
- CRACR2A p.Val132Leu Uncertain significance Single submitter
- CRACR2A p.Val505Leu Uncertain significance Single submitter
Predictors split 56
The independent predictors disagree with each other — read with care.
- CRACR2A p.Ala555Val Uncertain significance Single submitter
- CRACR2A p.Ala575Val Uncertain significance Single submitter
- CRACR2A p.Ala595Val Uncertain significance Single submitter
- CRACR2A p.Arg317Trp Uncertain significance Single submitter
- CRACR2A p.Arg321Trp Uncertain significance Single submitter
- CRACR2A p.Arg353Cys Uncertain significance Single submitter
- CRACR2A p.Arg353His Uncertain significance Single submitter
- CRACR2A p.Arg360Cys Uncertain significance Single submitter
- CRACR2A p.Arg360His Uncertain significance Single submitter
- CRACR2A p.Arg380Trp Uncertain significance Single submitter
- CRACR2A p.Arg383Trp Uncertain significance Single submitter
- CRACR2A p.Arg469Cys Uncertain significance Single submitter
- CRACR2A p.Arg544Gln Uncertain significance Single submitter
- CRACR2A p.Arg569Trp Uncertain significance Single submitter
- CRACR2A p.Arg583Cys Uncertain significance Single submitter
- CRACR2A p.Arg666Gln Uncertain significance Single submitter
- CRACR2A p.Arg666Trp Uncertain significance Single submitter
- CRACR2A p.Arg670Trp Uncertain significance Single submitter
- CRACR2A p.Asp590Tyr Uncertain significance Single submitter
- CRACR2A p.Gln264Glu Uncertain significance Single submitter
- CRACR2A p.Gln604Arg Uncertain significance Single submitter
- CRACR2A p.Glu154Lys Benign Single submitter
- CRACR2A p.Glu189Lys Uncertain significance Single submitter
- CRACR2A p.Glu274Gly Uncertain significance Single submitter
- CRACR2A p.Glu428Lys Uncertain significance Single submitter
- CRACR2A p.Glu667Asp Uncertain significance Single submitter
- CRACR2A p.Gly100Ser Uncertain significance Single submitter
- CRACR2A p.Gly100Val Uncertain significance Single submitter
- CRACR2A p.Gly168Val Uncertain significance Single submitter
- CRACR2A p.Gly364Arg Uncertain significance Single submitter
- CRACR2A p.Gly462Cys Uncertain significance Single submitter
- CRACR2A p.His192Arg Uncertain significance Single submitter
- CRACR2A p.His212Asp Uncertain significance Single submitter
- CRACR2A p.His344Pro Uncertain significance Single submitter
- CRACR2A p.Leu208Phe Uncertain significance Single submitter
- CRACR2A p.Leu266Met Uncertain significance Single submitter
- CRACR2A p.Leu319Met Uncertain significance Single submitter
- CRACR2A p.Leu336Phe Uncertain significance Single submitter
- CRACR2A p.Leu468Phe Uncertain significance Single submitter
- CRACR2A p.Leu587Val Likely benign Single submitter
- CRACR2A p.Leu676Ile Uncertain significance Single submitter
- CRACR2A p.Lys67Thr Uncertain significance Single submitter
- CRACR2A p.Lys707Gln Uncertain significance Single submitter
- CRACR2A p.Met164Arg Uncertain significance Single submitter
- CRACR2A p.Met624Thr Uncertain significance Single submitter
- CRACR2A p.Phe433Leu Uncertain significance Single submitter
- CRACR2A p.Phe570Tyr Uncertain significance Single submitter
- CRACR2A p.Pro83Leu Uncertain significance Single submitter
- CRACR2A p.Ser10Cys Uncertain significance Single submitter
- CRACR2A p.Ser501Phe Uncertain significance Single submitter
- CRACR2A p.Thr355Met Uncertain significance Single submitter
- CRACR2A p.Thr45Met Uncertain significance Single submitter
- CRACR2A p.Thr695Ala Uncertain significance Single submitter
- CRACR2A p.Tyr229Cys Uncertain significance Single submitter
- CRACR2A p.Tyr685Cys Uncertain significance Single submitter
- CRACR2A p.Glu278Asp Uncertain significance No assertion criteria
All CRACR2A variants
Benign 19
- c.1046+61T>C Single submitter
- c.1118+160A>G Single submitter
- c.1165-42A>G Single submitter
- c.1736-68G>A Single submitter
- c.1818-18G>A Single submitter
- c.1818-29A>G Single submitter
- c.229-37dup Single submitter
- c.229-47C>G Single submitter
- c.229-48C>T Single submitter
- c.229-92A>C Single submitter
- c.525-21T>C Single submitter
- c.762+25G>T Single submitter
- p.Ala128Val Single submitter
- p.Ala98Thr Single submitter
- p.Arg7Gly Single submitter
- p.Glu154Lys Single submitter ⚠
- p.His212Gln Single submitter
- p.Leu194= Single submitter
- p.Lys139= Single submitter
Likely benign 8
- c.1602+6G>A Single submitter
- p.Arg161Gln Single submitter
- p.Arg317Gln Single submitter
- p.Asn122= Single submitter
- p.Asn591Asp Single submitter
- p.Leu532Val Single submitter
- p.Leu587Val Single submitter ⚠
- p.Lys630Arg Single submitter
Uncertain significance 114
- p.Ala211Thr Single submitter ⚠
- p.Ala340Val Single submitter ⚠
- p.Ala392Ser Single submitter ⚠
- p.Ala555Val Single submitter ⚠
- p.Ala575Val Single submitter ⚠
- p.Ala595Val Single submitter ⚠
- p.Ala646Ser Single submitter ⚠
- p.Ala703Thr Single submitter ⚠
- p.Ala71Ser Single submitter ⚠
- p.Ala71Thr Single submitter ⚠
- p.Arg135Cys Single submitter ⚠
- p.Arg317Trp Single submitter ⚠
- p.Arg321Trp Single submitter ⚠
- p.Arg353Cys Single submitter ⚠
- p.Arg353His Single submitter ⚠
- p.Arg360Cys Single submitter ⚠
- p.Arg360His Single submitter ⚠
- p.Arg380Trp Single submitter ⚠
- p.Arg383Trp Single submitter ⚠
- p.Arg419Thr Single submitter ⚠
- p.Arg466Gln Single submitter ⚠
- p.Arg469Cys Single submitter ⚠
- p.Arg469His Single submitter ⚠
- p.Arg523Gln Single submitter ⚠
- p.Arg544Gln Single submitter ⚠
- p.Arg569Gln Single submitter ⚠
- p.Arg569Trp Single submitter ⚠
- p.Arg583Cys Single submitter ⚠
- p.Arg583His Single submitter ⚠
- p.Arg637Gln Single submitter ⚠
- p.Arg666Gln Single submitter ⚠
- p.Arg666Trp Single submitter ⚠
- p.Arg670Trp Single submitter ⚠
- p.Asn390Ser Single submitter ⚠
- p.Asp148Val Single submitter ⚠
- p.Asp151Asn Single submitter ⚠
- p.Asp502Glu Single submitter ⚠
- p.Asp590Tyr Single submitter ⚠
- p.Asp63Glu Single submitter ⚠
- p.Gln243Pro Single submitter ⚠
- p.Gln264Glu Single submitter ⚠
- p.Gln604Arg Single submitter ⚠
- p.Gln612Glu Single submitter ⚠
- p.Glu108Lys Single submitter ⚠
- p.Glu108Val Single submitter ⚠
- p.Glu189Lys Single submitter ⚠
- p.Glu274Gly Single submitter ⚠
- p.Glu428Lys Single submitter ⚠
- p.Glu667Asp Single submitter ⚠
- p.Glu667Gln Single submitter ⚠
- p.Gly100Ser Single submitter ⚠
- p.Gly100Val Single submitter ⚠
- p.Gly168Val Single submitter ⚠
- p.Gly25Ala Single submitter ⚠
- p.Gly364Arg Single submitter ⚠
- p.Gly461Glu Single submitter ⚠
- p.Gly462Cys Single submitter ⚠
- p.Gly47Asp Single submitter ⚠
- p.Gly524Glu Single submitter ⚠
- p.Gly673Arg Single submitter ⚠
- p.Gly721Ser Single submitter ⚠
- p.His192Arg Single submitter ⚠
- p.His212Asp Single submitter ⚠
- p.His299Leu Single submitter ⚠
- p.His344Pro Single submitter ⚠
- p.Ile412Thr Single submitter ⚠
- p.Ile683Leu Single submitter ⚠
- p.Leu104Met Single submitter ⚠
- p.Leu208Phe Single submitter ⚠
- p.Leu266Met Single submitter ⚠
- p.Leu319Met Single submitter ⚠
- p.Leu336Phe Single submitter ⚠
- p.Leu468Phe Single submitter ⚠
- p.Leu676Ile Single submitter ⚠
- p.Leu682Gln Single submitter ⚠
- p.Leu86Pro Single submitter ⚠
- p.Lys171Asn Single submitter ⚠
- p.Lys394Asn Single submitter ⚠
- p.Lys67Thr Single submitter ⚠
- p.Lys707Gln Single submitter ⚠
- p.Met164Arg Single submitter ⚠
- p.Met164Leu Single submitter ⚠
- p.Met624Thr Single submitter ⚠
- p.Phe433Leu Single submitter ⚠
- p.Phe570Leu Single submitter ⚠
- p.Phe570Tyr Single submitter ⚠
- p.Pro447Arg Single submitter ⚠
- p.Pro463Leu Single submitter ⚠
- p.Pro465Ala Single submitter ⚠
- p.Pro465Arg Single submitter ⚠
- p.Pro480Leu Single submitter ⚠
- p.Pro510Leu Single submitter ⚠
- p.Pro513Leu Single submitter ⚠
- p.Pro519Leu Single submitter ⚠
- p.Pro83Leu Single submitter ⚠
- p.Ser10Cys Single submitter ⚠
- p.Ser501Phe Single submitter ⚠
- p.Ser554Phe Single submitter ⚠
- p.Thr111Ser Single submitter ⚠
- p.Thr355Met Single submitter ⚠
- p.Thr449Arg Single submitter ⚠
- p.Thr455Ser Single submitter ⚠
- p.Thr45Met Single submitter ⚠
- p.Thr518Ala Single submitter ⚠
- p.Thr601Lys Single submitter ⚠
- p.Thr695Ala Single submitter ⚠
- p.Tyr141Cys Single submitter ⚠
- p.Tyr229Cys Single submitter ⚠
- p.Tyr464His Single submitter ⚠
- p.Tyr607His Single submitter ⚠
- p.Tyr685Cys Single submitter ⚠
- p.Val132Leu Single submitter ⚠
- p.Val505Leu Single submitter ⚠
- p.Glu278Asp No assertion criteria ⚠