CRACR2B — 50 ClinVar variants
All ClinVar germline CRACR2B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
1 Likely benign · 49 Uncertain significance
Full CRACR2B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRACR2B p.Ala104Glu Uncertain significance Single submitter
- CRACR2B p.Ala156Thr Uncertain significance Single submitter
- CRACR2B p.Ala182Thr Uncertain significance Single submitter
- CRACR2B p.Ala34Pro Uncertain significance Single submitter
- CRACR2B p.Ala45Val Uncertain significance Single submitter
- CRACR2B p.Arg155Gly Uncertain significance Single submitter
- CRACR2B p.Arg181His Uncertain significance Single submitter
- CRACR2B p.Arg238Gly Uncertain significance Single submitter
- CRACR2B p.Arg27Trp Uncertain significance Single submitter
- CRACR2B p.Asp10Asn Uncertain significance Single submitter
- CRACR2B p.Asp53Asn Uncertain significance Single submitter
- CRACR2B p.Cys89Ser Uncertain significance Single submitter
- CRACR2B p.Gln165His Uncertain significance Single submitter
- CRACR2B p.Gln67Leu Uncertain significance Single submitter
- CRACR2B p.Glu130Ala Uncertain significance Single submitter
- CRACR2B p.Glu131Ala Uncertain significance Single submitter
- CRACR2B p.Glu167Gln Uncertain significance Single submitter
- CRACR2B p.Glu208Gln Uncertain significance Single submitter
- CRACR2B p.Glu20Lys Uncertain significance Single submitter
- CRACR2B p.Glu32Lys Uncertain significance Single submitter
- CRACR2B p.Glu36Asp Uncertain significance Single submitter
- CRACR2B p.Gly17Arg Uncertain significance Single submitter
- CRACR2B p.Gly25Arg Uncertain significance Single submitter
- CRACR2B p.Gly47Ser Uncertain significance Single submitter
- CRACR2B p.Gly81Ser Uncertain significance Single submitter
- CRACR2B p.Gly97Glu Uncertain significance Single submitter
- CRACR2B p.Ile49Thr Uncertain significance Single submitter
- CRACR2B p.Leu214Val Uncertain significance Single submitter
- CRACR2B p.Leu31Val Uncertain significance Single submitter
- CRACR2B p.Met327Val Uncertain significance Single submitter
- CRACR2B p.Phe38Ser Uncertain significance Single submitter
- CRACR2B p.Pro26Arg Uncertain significance Single submitter
- CRACR2B p.Pro26Leu Uncertain significance Single submitter
- CRACR2B p.Ser127Cys Uncertain significance Single submitter
- CRACR2B p.Ser225Gly Uncertain significance Single submitter
- CRACR2B p.Val121Met Uncertain significance Single submitter
- CRACR2B p.Val178Ala Uncertain significance Single submitter
- CRACR2B p.Val71Ala Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- CRACR2B p.Ala184Asp Uncertain significance Single submitter
- CRACR2B p.Arg193Pro Uncertain significance Single submitter
- CRACR2B p.Arg336Trp Uncertain significance Single submitter
- CRACR2B p.Glu16Lys Uncertain significance Single submitter
- CRACR2B p.Glu210Gly Uncertain significance Single submitter
- CRACR2B p.Leu31Pro Uncertain significance Single submitter
- CRACR2B p.Leu341Phe Uncertain significance Single submitter
- CRACR2B p.Phe114Leu Uncertain significance Single submitter
- CRACR2B p.Trp161Leu Uncertain significance Single submitter
All CRACR2B variants
Likely benign 1
- p.Arg27Gln Single submitter
Uncertain significance 49
- p.Ala104Glu Single submitter ⚠
- p.Ala156Thr Single submitter ⚠
- p.Ala182Thr Single submitter ⚠
- p.Ala184Asp Single submitter ⚠
- p.Ala34Pro Single submitter ⚠
- p.Ala45Val Single submitter ⚠
- p.Arg155Gly Single submitter ⚠
- p.Arg181His Single submitter ⚠
- p.Arg193Pro Single submitter ⚠
- p.Arg238Gly Single submitter ⚠
- p.Arg27Trp Single submitter ⚠
- p.Arg325= Single submitter
- p.Arg336Trp Single submitter ⚠
- p.Asp10Asn Single submitter ⚠
- p.Asp53Asn Single submitter ⚠
- p.Cys89Ser Single submitter ⚠
- p.Gln165His Single submitter ⚠
- p.Gln67Leu Single submitter ⚠
- p.Glu130Ala Single submitter ⚠
- p.Glu131Ala Single submitter ⚠
- p.Glu167Gln Single submitter ⚠
- p.Glu16Lys Single submitter ⚠
- p.Glu208Gln Single submitter ⚠
- p.Glu20Lys Single submitter ⚠
- p.Glu210Gly Single submitter ⚠
- p.Glu32Lys Single submitter ⚠
- p.Glu36Asp Single submitter ⚠
- p.Gly17Arg Single submitter ⚠
- p.Gly25Arg Single submitter ⚠
- p.Gly47Ser Single submitter ⚠
- p.Gly81Ser Single submitter ⚠
- p.Gly97Glu Single submitter ⚠
- p.Ile49Thr Single submitter ⚠
- p.Leu214Val Single submitter ⚠
- p.Leu31Pro Single submitter ⚠
- p.Leu31Val Single submitter ⚠
- p.Leu334= Single submitter
- p.Leu341Phe Single submitter ⚠
- p.Met327Val Single submitter ⚠
- p.Phe114Leu Single submitter ⚠
- p.Phe38Ser Single submitter ⚠
- p.Pro26Arg Single submitter ⚠
- p.Pro26Leu Single submitter ⚠
- p.Ser127Cys Single submitter ⚠
- p.Ser225Gly Single submitter ⚠
- p.Trp161Leu Single submitter ⚠
- p.Val121Met Single submitter ⚠
- p.Val178Ala Single submitter ⚠
- p.Val71Ala Single submitter ⚠