CRB3 — 23 ClinVar variants
All ClinVar germline CRB3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
1 Likely benign · 22 Uncertain significance
Full CRB3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRB3 p.Arg20Cys Uncertain significance Single submitter
- CRB3 p.Glu85Lys Uncertain significance Single submitter
- CRB3 p.Ile57Thr Uncertain significance Single submitter
- CRB3 p.Thr30Ser Uncertain significance Single submitter
- CRB3 p.Thr89Met Uncertain significance Single submitter
- CRB3 p.Val80Leu Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- CRB3 p.Ala11Glu Uncertain significance Single submitter
- CRB3 p.Arg81Trp Likely benign Single submitter
- CRB3 p.Arg94Trp Uncertain significance Single submitter
- CRB3 p.Glu55Lys Uncertain significance Single submitter
- CRB3 p.Glu98Lys Uncertain significance Single submitter
- CRB3 p.Ile61Asn Uncertain significance Single submitter
- CRB3 p.Leu66Phe Uncertain significance Single submitter
- CRB3 p.Leu8Met Uncertain significance Single submitter
- CRB3 p.Leu9Pro Uncertain significance Single submitter
- CRB3 p.Pro15Arg Uncertain significance Single submitter
- CRB3 p.Ser32Phe Uncertain significance Single submitter
- CRB3 p.Ser46Cys Uncertain significance Single submitter
All CRB3 variants
Likely benign 1
- p.Arg81Trp Single submitter ⚠
Uncertain significance 22
- c.*294G>A Single submitter
- c.*300C>T Single submitter
- c.*304C>T Single submitter
- c.*314C>G Single submitter
- c.*342C>T Single submitter
- p.Ala11Glu Single submitter ⚠
- p.Arg20Cys Single submitter ⚠
- p.Arg94Trp Single submitter ⚠
- p.Glu55Lys Single submitter ⚠
- p.Glu85Lys Single submitter ⚠
- p.Glu98Lys Single submitter ⚠
- p.Ile57Thr Single submitter ⚠
- p.Ile61Asn Single submitter ⚠
- p.Leu66Phe Single submitter ⚠
- p.Leu8Met Single submitter ⚠
- p.Leu9Pro Single submitter ⚠
- p.Pro15Arg Single submitter ⚠
- p.Ser32Phe Single submitter ⚠
- p.Ser46Cys Single submitter ⚠
- p.Thr30Ser Single submitter ⚠
- p.Thr89Met Single submitter ⚠
- p.Val80Leu Single submitter ⚠