CREG2 — 52 ClinVar variants
All ClinVar germline CREG2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 52 flagged for review →
1 Likely benign · 51 Uncertain significance
Full CREG2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 52
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CREG2 p.Ala133Val Uncertain significance Single submitter
- CREG2 p.Ala290Ser Uncertain significance Single submitter
- CREG2 p.Ala290Val Uncertain significance Single submitter
- CREG2 p.Ala29Ser Uncertain significance Single submitter
- CREG2 p.Ala29Thr Uncertain significance Single submitter
- CREG2 p.Ala99Pro Uncertain significance Single submitter
- CREG2 p.Arg107Leu Uncertain significance Single submitter
- CREG2 p.Arg251His Uncertain significance Single submitter
- CREG2 p.Arg279Ser Uncertain significance Single submitter
- CREG2 p.Arg288Gly Uncertain significance Single submitter
- CREG2 p.Arg4Leu Uncertain significance Single submitter
- CREG2 p.Arg93Gly Uncertain significance Single submitter
- CREG2 p.Asp51Val Uncertain significance Single submitter
- CREG2 p.Glu45Lys Uncertain significance Single submitter
- CREG2 p.Glu64Val Uncertain significance Single submitter
- CREG2 p.Gly222Ala Uncertain significance Single submitter
- CREG2 p.His145Tyr Uncertain significance Single submitter
- CREG2 p.His264Tyr Uncertain significance Single submitter
- CREG2 p.Ile207Thr Uncertain significance Single submitter
- CREG2 p.Ile265Thr Uncertain significance Single submitter
- CREG2 p.Met175Leu Uncertain significance Single submitter
- CREG2 p.Met186Leu Uncertain significance Single submitter
- CREG2 p.Met239Thr Uncertain significance Single submitter
- CREG2 p.Pro12Arg Uncertain significance Single submitter
- CREG2 p.Pro75Ser Uncertain significance Single submitter
- CREG2 p.Ser39Thr Uncertain significance Single submitter
- CREG2 p.Ser73Ile Uncertain significance Single submitter
- CREG2 p.Trp136Arg Uncertain significance Single submitter
- CREG2 p.Val208Ile Uncertain significance Single submitter
- CREG2 p.Val3Leu Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- CREG2 p.Ala124Pro Likely benign Single submitter
- CREG2 p.Ala30Glu Uncertain significance Single submitter
- CREG2 p.Ala92Val Uncertain significance Single submitter
- CREG2 p.Arg4His Uncertain significance Single submitter
- CREG2 p.Glu48Lys Uncertain significance Single submitter
- CREG2 p.Glu57Lys Uncertain significance Single submitter
- CREG2 p.His243Tyr Uncertain significance Single submitter
- CREG2 p.His264Gln Uncertain significance Single submitter
- CREG2 p.Leu26Pro Uncertain significance Single submitter
- CREG2 p.Phe202Leu Uncertain significance Single submitter
- CREG2 p.Pro163Ala Uncertain significance Single submitter
- CREG2 p.Pro213Leu Uncertain significance Single submitter
- CREG2 p.Pro287Ser Uncertain significance Single submitter
- CREG2 p.Ser105Cys Uncertain significance Single submitter
- CREG2 p.Ser134Arg Uncertain significance Single submitter
- CREG2 p.Ser143Pro Uncertain significance Single submitter
- CREG2 p.Ser160Cys Uncertain significance Single submitter
- CREG2 p.Ser27Tyr Uncertain significance Single submitter
- CREG2 p.Ser73Asn Uncertain significance Single submitter
- CREG2 p.Thr113Met Uncertain significance Single submitter
- CREG2 p.Val216Phe Uncertain significance Single submitter
- CREG2 p.Val232Ala Uncertain significance Single submitter
All CREG2 variants
Likely benign 1
- p.Ala124Pro Single submitter ⚠
Uncertain significance 51
- p.Ala133Val Single submitter ⚠
- p.Ala290Ser Single submitter ⚠
- p.Ala290Val Single submitter ⚠
- p.Ala29Ser Single submitter ⚠
- p.Ala29Thr Single submitter ⚠
- p.Ala30Glu Single submitter ⚠
- p.Ala92Val Single submitter ⚠
- p.Ala99Pro Single submitter ⚠
- p.Arg107Leu Single submitter ⚠
- p.Arg251His Single submitter ⚠
- p.Arg279Ser Single submitter ⚠
- p.Arg288Gly Single submitter ⚠
- p.Arg4His Single submitter ⚠
- p.Arg4Leu Single submitter ⚠
- p.Arg93Gly Single submitter ⚠
- p.Asp51Val Single submitter ⚠
- p.Glu45Lys Single submitter ⚠
- p.Glu48Lys Single submitter ⚠
- p.Glu57Lys Single submitter ⚠
- p.Glu64Val Single submitter ⚠
- p.Gly222Ala Single submitter ⚠
- p.His145Tyr Single submitter ⚠
- p.His243Tyr Single submitter ⚠
- p.His264Gln Single submitter ⚠
- p.His264Tyr Single submitter ⚠
- p.Ile207Thr Single submitter ⚠
- p.Ile265Thr Single submitter ⚠
- p.Leu26Pro Single submitter ⚠
- p.Met175Leu Single submitter ⚠
- p.Met186Leu Single submitter ⚠
- p.Met239Thr Single submitter ⚠
- p.Phe202Leu Single submitter ⚠
- p.Pro12Arg Single submitter ⚠
- p.Pro163Ala Single submitter ⚠
- p.Pro213Leu Single submitter ⚠
- p.Pro287Ser Single submitter ⚠
- p.Pro75Ser Single submitter ⚠
- p.Ser105Cys Single submitter ⚠
- p.Ser134Arg Single submitter ⚠
- p.Ser143Pro Single submitter ⚠
- p.Ser160Cys Single submitter ⚠
- p.Ser27Tyr Single submitter ⚠
- p.Ser39Thr Single submitter ⚠
- p.Ser73Asn Single submitter ⚠
- p.Ser73Ile Single submitter ⚠
- p.Thr113Met Single submitter ⚠
- p.Trp136Arg Single submitter ⚠
- p.Val208Ile Single submitter ⚠
- p.Val216Phe Single submitter ⚠
- p.Val232Ala Single submitter ⚠
- p.Val3Leu Single submitter ⚠