CRELD2 — 96 ClinVar variants
All ClinVar germline CRELD2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 76 flagged for review →
3 Benign · 1 Benign/Likely benign · 5 Likely benign · 87 Uncertain significance
Full CRELD2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 76
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRELD2 p.Ala227Thr Uncertain significance Single submitter
- CRELD2 p.Ala282Val Uncertain significance Single submitter
- CRELD2 p.Ala289Glu Uncertain significance Single submitter
- CRELD2 p.Arg189Gln Uncertain significance Single submitter
- CRELD2 p.Asp232Asn Uncertain significance Single submitter
- CRELD2 p.Asp352Glu Uncertain significance Single submitter
- CRELD2 p.Cys166Ser Uncertain significance Single submitter
- CRELD2 p.Cys288Tyr Uncertain significance Single submitter
- CRELD2 p.Gln173Arg Uncertain significance Single submitter
- CRELD2 p.Glu201Lys Uncertain significance Single submitter
- CRELD2 p.Glu218Lys Uncertain significance Single submitter
- CRELD2 p.Glu258Ala Uncertain significance Single submitter
- CRELD2 p.Glu293Lys Uncertain significance Single submitter
- CRELD2 p.Glu324Lys Uncertain significance Single submitter
- CRELD2 p.Glu342Asp Uncertain significance Single submitter
- CRELD2 p.Glu72Lys Uncertain significance Single submitter
- CRELD2 p.Gly134Arg Uncertain significance Single submitter
- CRELD2 p.Gly134Cys Uncertain significance Single submitter
- CRELD2 p.Gly156Arg Uncertain significance Single submitter
- CRELD2 p.Gly162Asp Uncertain significance Single submitter
- CRELD2 p.Gly164Arg Uncertain significance Single submitter
- CRELD2 p.Gly280Asp Uncertain significance Single submitter
- CRELD2 p.Gly36Arg Uncertain significance Single submitter
- CRELD2 p.Gly56Arg Uncertain significance Single submitter
- CRELD2 p.Ile278Thr Uncertain significance Single submitter
- CRELD2 p.Met181Thr Uncertain significance Single submitter
- CRELD2 p.Pro22Leu Uncertain significance Single submitter
- CRELD2 p.Pro348Ala Uncertain significance Single submitter
- CRELD2 p.Ser110Gly Uncertain significance Single submitter
- CRELD2 p.Ser144Pro Uncertain significance Single submitter
- CRELD2 p.Ser194Arg Uncertain significance Single submitter
- CRELD2 p.Ser295Leu Uncertain significance Single submitter
- CRELD2 p.Ser343Asn Uncertain significance Single submitter
- CRELD2 p.Thr255Ala Uncertain significance Single submitter
- CRELD2 p.Thr339Ala Uncertain significance Single submitter
- CRELD2 p.Trp118Cys Uncertain significance Single submitter
- CRELD2 p.Tyr315Cys Uncertain significance Single submitter
- CRELD2 p.Val316Ile Uncertain significance Single submitter
Predictors split 38
The independent predictors disagree with each other — read with care.
- CRELD2 p.Ala235Val Uncertain significance Single submitter
- CRELD2 p.Arg167Trp Uncertain significance Single submitter
- CRELD2 p.Arg212Gly Uncertain significance Single submitter
- CRELD2 p.Arg2Pro Uncertain significance Single submitter
- CRELD2 p.Arg33Gln Uncertain significance Single submitter
- CRELD2 p.Arg33Gly Uncertain significance Single submitter
- CRELD2 p.Arg33Trp Uncertain significance Single submitter
- CRELD2 p.Arg5Cys Uncertain significance Single submitter
- CRELD2 p.Arg6Gln Uncertain significance Single submitter
- CRELD2 p.Asn190Ser Uncertain significance Single submitter
- CRELD2 p.Asn211Ser Uncertain significance Single submitter
- CRELD2 p.Asp136Asn Uncertain significance Single submitter
- CRELD2 p.Gln92Arg Uncertain significance Single submitter
- CRELD2 p.Gln92His Uncertain significance Single submitter
- CRELD2 p.Gln97Arg Uncertain significance Single submitter
- CRELD2 p.Glu257Lys Uncertain significance Single submitter
- CRELD2 p.Glu306Lys Uncertain significance Single submitter
- CRELD2 p.Glu325Asp Uncertain significance Single submitter
- CRELD2 p.Glu340Val Uncertain significance Single submitter
- CRELD2 p.Gly134Ser Uncertain significance Single submitter
- CRELD2 p.Gly150Arg Uncertain significance Single submitter
- CRELD2 p.Gly183Ala Uncertain significance Single submitter
- CRELD2 p.Gly183Ser Uncertain significance Single submitter
- CRELD2 p.Gly322Ser Uncertain significance Single submitter
- CRELD2 p.Gly322Val Uncertain significance Single submitter
- CRELD2 p.Leu14Phe Uncertain significance Single submitter
- CRELD2 p.Leu188Pro Uncertain significance Single submitter
- CRELD2 p.Phe116Leu Uncertain significance Single submitter
- CRELD2 p.Pro175Leu Uncertain significance Single submitter
- CRELD2 p.Pro312Ala Uncertain significance Single submitter
- CRELD2 p.Pro312Leu Uncertain significance Single submitter
- CRELD2 p.Ser207Leu Uncertain significance Single submitter
- CRELD2 p.Ser349Cys Uncertain significance Single submitter
- CRELD2 p.Thr205Arg Uncertain significance Single submitter
- CRELD2 p.Thr255Met Uncertain significance Single submitter
- CRELD2 p.Thr326Met Uncertain significance Single submitter
- CRELD2 p.Val231Met Uncertain significance Single submitter
- CRELD2 p.Val38Leu Uncertain significance Single submitter
All CRELD2 variants
Benign 3
- p.Ala236= Multiple submitters
- p.Gly162= Multiple submitters
- c.593-322_593-286del Single submitter
Benign/Likely benign 1
- p.Cys294= Multiple submitters
Likely benign 5
- p.Ala282Thr Single submitter
- p.Arg167Gln Single submitter
- p.Asn249= Single submitter
- p.Lys248Glu Single submitter
- p.Ser207= Single submitter
Uncertain significance 87
- c.593-181G>T Single submitter
- c.593-202A>T Single submitter
- c.593-208G>T Single submitter
- c.593-222C>T Single submitter
- c.593-228G>A Single submitter
- c.593-229C>T Single submitter
- c.593-234G>A Single submitter
- c.593-241T>C Single submitter
- c.593-244G>A Single submitter
- c.593-294C>G Single submitter
- c.593-313A>G Single submitter
- p.Ala227Thr Single submitter ⚠
- p.Ala235Val Single submitter ⚠
- p.Ala282Val Single submitter ⚠
- p.Ala289Glu Single submitter ⚠
- p.Arg167Trp Single submitter ⚠
- p.Arg189Gln Single submitter ⚠
- p.Arg212Gly Single submitter ⚠
- p.Arg2Pro Single submitter ⚠
- p.Arg33Gln Single submitter ⚠
- p.Arg33Gly Single submitter ⚠
- p.Arg33Trp Single submitter ⚠
- p.Arg5Cys Single submitter ⚠
- p.Arg6Gln Single submitter ⚠
- p.Asn190Ser Single submitter ⚠
- p.Asn211Ser Single submitter ⚠
- p.Asp136Asn Single submitter ⚠
- p.Asp232Asn Single submitter ⚠
- p.Asp352Glu Single submitter ⚠
- p.Cys166Ser Single submitter ⚠
- p.Cys288Tyr Single submitter ⚠
- p.Gln173Arg Single submitter ⚠
- p.Gln92Arg Single submitter ⚠
- p.Gln92His Single submitter ⚠
- p.Gln97Arg Single submitter ⚠
- p.Glu201Lys Single submitter ⚠
- p.Glu218Lys Single submitter ⚠
- p.Glu257Lys Single submitter ⚠
- p.Glu258Ala Single submitter ⚠
- p.Glu293Lys Single submitter ⚠
- p.Glu306Lys Single submitter ⚠
- p.Glu324Lys Single submitter ⚠
- p.Glu325Asp Single submitter ⚠
- p.Glu340Val Single submitter ⚠
- p.Glu342Asp Single submitter ⚠
- p.Glu72Lys Single submitter ⚠
- p.Gly134Arg Single submitter ⚠
- p.Gly134Cys Single submitter ⚠
- p.Gly134Ser Single submitter ⚠
- p.Gly150Arg Single submitter ⚠
- p.Gly156Arg Single submitter ⚠
- p.Gly162Asp Single submitter ⚠
- p.Gly164Arg Single submitter ⚠
- p.Gly183Ala Single submitter ⚠
- p.Gly183Ser Single submitter ⚠
- p.Gly280Asp Single submitter ⚠
- p.Gly322Ser Single submitter ⚠
- p.Gly322Val Single submitter ⚠
- p.Gly36Arg Single submitter ⚠
- p.Gly56Arg Single submitter ⚠
- p.Ile278Thr Single submitter ⚠
- p.Leu14Phe Single submitter ⚠
- p.Leu188Pro Single submitter ⚠
- p.Met181Thr Single submitter ⚠
- p.Phe116Leu Single submitter ⚠
- p.Pro175Leu Single submitter ⚠
- p.Pro22Leu Single submitter ⚠
- p.Pro312Ala Single submitter ⚠
- p.Pro312Leu Single submitter ⚠
- p.Pro348Ala Single submitter ⚠
- p.Ser110Gly Single submitter ⚠
- p.Ser144Pro Single submitter ⚠
- p.Ser194Arg Single submitter ⚠
- p.Ser207Leu Single submitter ⚠
- p.Ser295Leu Single submitter ⚠
- p.Ser343Asn Single submitter ⚠
- p.Ser349Cys Single submitter ⚠
- p.Thr205Arg Single submitter ⚠
- p.Thr255Ala Single submitter ⚠
- p.Thr255Met Single submitter ⚠
- p.Thr326Met Single submitter ⚠
- p.Thr339Ala Single submitter ⚠
- p.Trp118Cys Single submitter ⚠
- p.Tyr315Cys Single submitter ⚠
- p.Val231Met Single submitter ⚠
- p.Val316Ile Single submitter ⚠
- p.Val38Leu Single submitter ⚠