CRIP2 — 43 ClinVar variants
All ClinVar germline CRIP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 38 flagged for review →
1 Benign · 4 Likely benign · 38 Uncertain significance
Full CRIP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 38
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRIP2 p.Ala113Val Uncertain significance Single submitter
- CRIP2 p.Ala166Thr Uncertain significance Single submitter
- CRIP2 p.Ala82Thr Uncertain significance Single submitter
- CRIP2 p.Ala96Gly Uncertain significance Single submitter
- CRIP2 p.Ala98Thr Uncertain significance Single submitter
- CRIP2 p.Arg148Gly Uncertain significance Single submitter
- CRIP2 p.Arg148Trp Uncertain significance Single submitter
- CRIP2 p.Arg200Gln Uncertain significance Single submitter
- CRIP2 p.Arg97Gln Uncertain significance Single submitter
- CRIP2 p.Cys53Tyr Uncertain significance Single submitter
- CRIP2 p.Glu83Gly Uncertain significance Single submitter
- CRIP2 p.Glu92Asp Uncertain significance Single submitter
- CRIP2 p.Gly194Ser Uncertain significance Single submitter
- CRIP2 p.Gly89Asp Uncertain significance Single submitter
- CRIP2 p.His175Pro Uncertain significance Single submitter
- CRIP2 p.Leu81Met Uncertain significance Single submitter
- CRIP2 p.Lys176Asn Uncertain significance Single submitter
- CRIP2 p.Lys23Asn Uncertain significance Single submitter
- CRIP2 p.Phe135Leu Uncertain significance Single submitter
- CRIP2 p.Pro127Ser Uncertain significance Single submitter
- CRIP2 p.Pro172Ser Uncertain significance Single submitter
- CRIP2 p.Pro56Arg Uncertain significance Single submitter
- CRIP2 p.Pro85Gln Uncertain significance Single submitter
- CRIP2 p.Ser114Ala Uncertain significance Single submitter
- CRIP2 p.Ser74Phe Uncertain significance Single submitter
- CRIP2 p.Tyr58His Uncertain significance Single submitter
- CRIP2 p.Val139Met Uncertain significance Single submitter
- CRIP2 p.Val188Leu Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- CRIP2 p.Arg128His Uncertain significance Single submitter
- CRIP2 p.Gln86His Uncertain significance Single submitter
- CRIP2 p.Glu100Lys Uncertain significance Single submitter
- CRIP2 p.Gly157Glu Uncertain significance Single submitter
- CRIP2 p.Gly170Ser Uncertain significance Single submitter
- CRIP2 p.Ile197Val Uncertain significance Single submitter
- CRIP2 p.Lys205Arg Uncertain significance Single submitter
- CRIP2 p.Ser104Arg Uncertain significance Single submitter
- CRIP2 p.Ser111Arg Uncertain significance Single submitter
- CRIP2 p.Thr38Met Uncertain significance Single submitter
All CRIP2 variants
Benign 1
- p.Asp169= Single submitter
Likely benign 4
- p.Ala95Val Single submitter
- p.His70= Single submitter
- p.Ser36Asn Single submitter
- p.Thr88= Single submitter
Uncertain significance 38
- p.Ala113Val Single submitter ⚠
- p.Ala166Thr Single submitter ⚠
- p.Ala82Thr Single submitter ⚠
- p.Ala96Gly Single submitter ⚠
- p.Ala98Thr Single submitter ⚠
- p.Arg128His Single submitter ⚠
- p.Arg148Gly Single submitter ⚠
- p.Arg148Trp Single submitter ⚠
- p.Arg200Gln Single submitter ⚠
- p.Arg97Gln Single submitter ⚠
- p.Cys53Tyr Single submitter ⚠
- p.Gln86His Single submitter ⚠
- p.Glu100Lys Single submitter ⚠
- p.Glu83Gly Single submitter ⚠
- p.Glu92Asp Single submitter ⚠
- p.Gly157Glu Single submitter ⚠
- p.Gly170Ser Single submitter ⚠
- p.Gly194Ser Single submitter ⚠
- p.Gly89Asp Single submitter ⚠
- p.His175Pro Single submitter ⚠
- p.Ile197Val Single submitter ⚠
- p.Leu81Met Single submitter ⚠
- p.Lys176Asn Single submitter ⚠
- p.Lys205Arg Single submitter ⚠
- p.Lys23Asn Single submitter ⚠
- p.Phe135Leu Single submitter ⚠
- p.Pro127Ser Single submitter ⚠
- p.Pro172Ser Single submitter ⚠
- p.Pro56Arg Single submitter ⚠
- p.Pro85Gln Single submitter ⚠
- p.Ser104Arg Single submitter ⚠
- p.Ser111Arg Single submitter ⚠
- p.Ser114Ala Single submitter ⚠
- p.Ser74Phe Single submitter ⚠
- p.Thr38Met Single submitter ⚠
- p.Tyr58His Single submitter ⚠
- p.Val139Met Single submitter ⚠
- p.Val188Leu Single submitter ⚠