CRIP3 — 30 ClinVar variants
All ClinVar germline CRIP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
1 Likely benign · 29 Uncertain significance
Full CRIP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRIP3 p.Ala60Thr Uncertain significance Single submitter
- CRIP3 p.Asn78Ser Uncertain significance Single submitter
- CRIP3 p.Cys127Tyr Uncertain significance Single submitter
- CRIP3 p.Cys151Tyr Uncertain significance Single submitter
- CRIP3 p.Cys154Phe Uncertain significance Single submitter
- CRIP3 p.Cys5Arg Uncertain significance Single submitter
- CRIP3 p.Gly161Glu Uncertain significance Single submitter
- CRIP3 p.His44Asn Uncertain significance Single submitter
- CRIP3 p.Pro89Ser Uncertain significance Single submitter
- CRIP3 p.Ser2Thr Uncertain significance Single submitter
- CRIP3 p.Thr88Ala Uncertain significance Single submitter
- CRIP3 p.Trp25Gly Uncertain significance Single submitter
- CRIP3 p.Tyr132His Uncertain significance Single submitter
- CRIP3 p.Tyr77His Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- CRIP3 p.Arg146Gln Uncertain significance Single submitter
- CRIP3 p.Arg50Trp Uncertain significance Single submitter
- CRIP3 p.Ile38Phe Uncertain significance Single submitter
- CRIP3 p.Phe13Leu Uncertain significance Single submitter
- CRIP3 p.Pro147Leu Uncertain significance Single submitter
- CRIP3 p.Ser110Asn Uncertain significance Single submitter
- CRIP3 p.Ser40Tyr Uncertain significance Single submitter
- CRIP3 p.Ser83Asn Uncertain significance Single submitter
- CRIP3 p.Ser94Gly Uncertain significance Single submitter
- CRIP3 p.Ser96Asn Uncertain significance Single submitter
- CRIP3 p.Thr118Ile Uncertain significance Single submitter
- CRIP3 p.Tyr75Cys Uncertain significance Single submitter
- CRIP3 p.Val131Ile Uncertain significance Single submitter
- CRIP3 p.Val174Ile Likely benign Single submitter
- CRIP3 p.Val67Leu Uncertain significance Single submitter
All CRIP3 variants
Likely benign 1
- p.Val174Ile Single submitter ⚠
Uncertain significance 29
- p.Ala60Thr Single submitter ⚠
- p.Arg146Gln Single submitter ⚠
- p.Arg50Trp Single submitter ⚠
- p.Asn78Ser Single submitter ⚠
- p.Cys127Tyr Single submitter ⚠
- p.Cys151Tyr Single submitter ⚠
- p.Cys154Phe Single submitter ⚠
- p.Cys5Arg Single submitter ⚠
- p.Gly161Glu Single submitter ⚠
- p.Gly192Asp Single submitter
- p.His44Asn Single submitter ⚠
- p.Ile38Phe Single submitter ⚠
- p.Phe13Leu Single submitter ⚠
- p.Pro147Leu Single submitter ⚠
- p.Pro89Ser Single submitter ⚠
- p.Ser110Asn Single submitter ⚠
- p.Ser2Thr Single submitter ⚠
- p.Ser40Tyr Single submitter ⚠
- p.Ser83Asn Single submitter ⚠
- p.Ser94Gly Single submitter ⚠
- p.Ser96Asn Single submitter ⚠
- p.Thr118Ile Single submitter ⚠
- p.Thr88Ala Single submitter ⚠
- p.Trp25Gly Single submitter ⚠
- p.Tyr132His Single submitter ⚠
- p.Tyr75Cys Single submitter ⚠
- p.Tyr77His Single submitter ⚠
- p.Val131Ile Single submitter ⚠
- p.Val67Leu Single submitter ⚠