CRLF3 — 43 ClinVar variants
All ClinVar germline CRLF3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
1 Likely benign · 42 Uncertain significance
Full CRLF3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRLF3 p.Ala308Ser Uncertain significance Single submitter
- CRLF3 p.Ala308Thr Uncertain significance Single submitter
- CRLF3 p.Arg348Gln Uncertain significance Single submitter
- CRLF3 p.Asn394Ser Uncertain significance Single submitter
- CRLF3 p.Asn60Lys Uncertain significance Single submitter
- CRLF3 p.Asp225Gly Uncertain significance Single submitter
- CRLF3 p.Asp240Glu Uncertain significance Single submitter
- CRLF3 p.Asp344Asn Uncertain significance Single submitter
- CRLF3 p.Asp420His Uncertain significance Single submitter
- CRLF3 p.Cys313Trp Uncertain significance Single submitter
- CRLF3 p.Cys423Arg Uncertain significance Single submitter
- CRLF3 p.Gln209Glu Uncertain significance Single submitter
- CRLF3 p.Gln421Glu Uncertain significance Single submitter
- CRLF3 p.Glu338Gln Uncertain significance Single submitter
- CRLF3 p.Glu338Lys Uncertain significance Single submitter
- CRLF3 p.Glu87Lys Uncertain significance Single submitter
- CRLF3 p.Glu8Asp Uncertain significance Single submitter
- CRLF3 p.Gly390Val Uncertain significance Single submitter
- CRLF3 p.Gly424Arg Uncertain significance Single submitter
- CRLF3 p.Ile195Val Uncertain significance Single submitter
- CRLF3 p.Leu12Val Uncertain significance Single submitter
- CRLF3 p.Lys173Asn Uncertain significance Single submitter
- CRLF3 p.Lys56Arg Uncertain significance Single submitter
- CRLF3 p.Phe312Ser Uncertain significance Single submitter
- CRLF3 p.Pro241Ser Uncertain significance Single submitter
- CRLF3 p.Ser301Leu Uncertain significance Single submitter
- CRLF3 p.Ser355Thr Uncertain significance Single submitter
- CRLF3 p.Thr88Ala Uncertain significance Single submitter
- CRLF3 p.Val103Ile Uncertain significance Single submitter
- CRLF3 p.Val228Ile Uncertain significance Single submitter
- CRLF3 p.Val236Ile Uncertain significance Single submitter
- CRLF3 p.Val321Ile Uncertain significance Single submitter
- CRLF3 p.Val380Ile Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- CRLF3 p.Arg38Cys Uncertain significance Single submitter
- CRLF3 p.Ile292Arg Uncertain significance Single submitter
- CRLF3 p.Leu155Ile Uncertain significance Single submitter
- CRLF3 p.Leu77Phe Uncertain significance Single submitter
- CRLF3 p.Lys97Met Uncertain significance Single submitter
- CRLF3 p.Ser260Gly Uncertain significance Single submitter
- CRLF3 p.Ser270Cys Uncertain significance Single submitter
- CRLF3 p.Val226Leu Uncertain significance Single submitter
- CRLF3 p.Val243Ile Uncertain significance Single submitter
All CRLF3 variants
Likely benign 1
- p.Arg111Gln Single submitter
Uncertain significance 42
- p.Ala308Ser Single submitter ⚠
- p.Ala308Thr Single submitter ⚠
- p.Arg348Gln Single submitter ⚠
- p.Arg38Cys Single submitter ⚠
- p.Asn394Ser Single submitter ⚠
- p.Asn60Lys Single submitter ⚠
- p.Asp225Gly Single submitter ⚠
- p.Asp240Glu Single submitter ⚠
- p.Asp344Asn Single submitter ⚠
- p.Asp420His Single submitter ⚠
- p.Cys313Trp Single submitter ⚠
- p.Cys423Arg Single submitter ⚠
- p.Gln209Glu Single submitter ⚠
- p.Gln421Glu Single submitter ⚠
- p.Glu338Gln Single submitter ⚠
- p.Glu338Lys Single submitter ⚠
- p.Glu87Lys Single submitter ⚠
- p.Glu8Asp Single submitter ⚠
- p.Gly390Val Single submitter ⚠
- p.Gly424Arg Single submitter ⚠
- p.Ile195Val Single submitter ⚠
- p.Ile292Arg Single submitter ⚠
- p.Leu12Val Single submitter ⚠
- p.Leu155Ile Single submitter ⚠
- p.Leu77Phe Single submitter ⚠
- p.Lys173Asn Single submitter ⚠
- p.Lys56Arg Single submitter ⚠
- p.Lys97Met Single submitter ⚠
- p.Phe312Ser Single submitter ⚠
- p.Pro241Ser Single submitter ⚠
- p.Ser260Gly Single submitter ⚠
- p.Ser270Cys Single submitter ⚠
- p.Ser301Leu Single submitter ⚠
- p.Ser355Thr Single submitter ⚠
- p.Thr88Ala Single submitter ⚠
- p.Val103Ile Single submitter ⚠
- p.Val226Leu Single submitter ⚠
- p.Val228Ile Single submitter ⚠
- p.Val236Ile Single submitter ⚠
- p.Val243Ile Single submitter ⚠
- p.Val321Ile Single submitter ⚠
- p.Val380Ile Single submitter ⚠