CRNN — 79 ClinVar variants
All ClinVar germline CRNN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 71 flagged for review →
8 Likely benign · 71 Uncertain significance
Full CRNN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 71
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 60
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRNN p.Ala109Asp Uncertain significance Single submitter
- CRNN p.Ala371Thr Uncertain significance Single submitter
- CRNN p.Ala473Thr Uncertain significance Single submitter
- CRNN p.Arg17His Uncertain significance Single submitter
- CRNN p.Arg424Pro Uncertain significance Single submitter
- CRNN p.Arg424Ser Uncertain significance Single submitter
- CRNN p.Arg479Pro Uncertain significance Single submitter
- CRNN p.Asn459Asp Uncertain significance Single submitter
- CRNN p.Asp361His Uncertain significance Single submitter
- CRNN p.Asp43Asn Uncertain significance Single submitter
- CRNN p.Asp444Glu Uncertain significance Single submitter
- CRNN p.Asp62His Uncertain significance Single submitter
- CRNN p.Asp62Val Uncertain significance Single submitter
- CRNN p.Gln147Lys Uncertain significance Single submitter
- CRNN p.Gln217Glu Uncertain significance Single submitter
- CRNN p.Gln233His Uncertain significance Single submitter
- CRNN p.Gln39Glu Uncertain significance Single submitter
- CRNN p.Glu115Lys Uncertain significance Single submitter
- CRNN p.Glu13Lys Uncertain significance Single submitter
- CRNN p.Glu225Lys Uncertain significance Single submitter
- CRNN p.Glu303Lys Uncertain significance Single submitter
- CRNN p.Glu397Val Uncertain significance Single submitter
- CRNN p.Glu476Gly Uncertain significance Single submitter
- CRNN p.Glu477Lys Uncertain significance Single submitter
- CRNN p.Glu91Lys Uncertain significance Single submitter
- CRNN p.Gly103Glu Uncertain significance Single submitter
- CRNN p.Gly108Val Uncertain significance Single submitter
- CRNN p.Gly143Cys Uncertain significance Single submitter
- CRNN p.Gly156Arg Uncertain significance Single submitter
- CRNN p.Gly160Val Uncertain significance Single submitter
- CRNN p.Gly237Ala Uncertain significance Single submitter
- CRNN p.Gly311Arg Uncertain significance Single submitter
- CRNN p.Gly31Ala Uncertain significance Single submitter
- CRNN p.Gly369Arg Uncertain significance Single submitter
- CRNN p.Gly402Arg Uncertain significance Single submitter
- CRNN p.Gly469Asp Uncertain significance Single submitter
- CRNN p.His137Arg Uncertain significance Single submitter
- CRNN p.Ile8Thr Uncertain significance Single submitter
- CRNN p.Leu105Pro Uncertain significance Single submitter
- CRNN p.Lys494Arg Uncertain significance Single submitter
- CRNN p.Pro181Leu Uncertain significance Single submitter
- CRNN p.Pro208Thr Uncertain significance Single submitter
- CRNN p.Ser102Pro Uncertain significance Single submitter
- CRNN p.Ser107Cys Uncertain significance Single submitter
- CRNN p.Ser110Leu Uncertain significance Single submitter
- CRNN p.Ser247Asn Uncertain significance Single submitter
- CRNN p.Ser254Arg Uncertain significance Single submitter
- CRNN p.Ser412Leu Uncertain significance Single submitter
- CRNN p.Ser447Pro Uncertain significance Single submitter
- CRNN p.Ser475Leu Uncertain significance Single submitter
- CRNN p.Ser488Cys Uncertain significance Single submitter
- CRNN p.Thr226Ile Uncertain significance Single submitter
- CRNN p.Thr26Arg Uncertain significance Single submitter
- CRNN p.Thr450Arg Uncertain significance Single submitter
- CRNN p.Thr66Ala Uncertain significance Single submitter
- CRNN p.Thr88Lys Uncertain significance Single submitter
- CRNN p.Val152Ile Uncertain significance Single submitter
- CRNN p.Val152Phe Uncertain significance Single submitter
- CRNN p.Val242Leu Uncertain significance Single submitter
- CRNN p.Val302Met Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- CRNN p.Gln340Arg Uncertain significance Single submitter
- CRNN p.Glu22Lys Uncertain significance Single submitter
- CRNN p.Gly334Val Uncertain significance Single submitter
- CRNN p.Ile11Thr Uncertain significance Single submitter
- CRNN p.Ile45Thr Uncertain significance Single submitter
- CRNN p.Leu28Val Uncertain significance Single submitter
- CRNN p.Leu36Phe Uncertain significance Single submitter
- CRNN p.Ser339Asn Uncertain significance Single submitter
- CRNN p.Thr234Pro Uncertain significance Single submitter
- CRNN p.Thr313Ile Uncertain significance Single submitter
- CRNN p.Tyr18Asn Uncertain significance Single submitter
All CRNN variants
Likely benign 8
- p.Ala260Ser Single submitter
- p.Arg386Lys Single submitter
- p.Arg479Gln Single submitter
- p.Gly198Asp Single submitter
- p.Gly272Ser Single submitter
- p.Gly98Ser Single submitter
- p.His368= Single submitter
- p.Pro181Gln Single submitter
Uncertain significance 71
- p.Ala109Asp Single submitter ⚠
- p.Ala371Thr Single submitter ⚠
- p.Ala473Thr Single submitter ⚠
- p.Arg17His Single submitter ⚠
- p.Arg424Pro Single submitter ⚠
- p.Arg424Ser Single submitter ⚠
- p.Arg479Pro Single submitter ⚠
- p.Asn459Asp Single submitter ⚠
- p.Asp361His Single submitter ⚠
- p.Asp43Asn Single submitter ⚠
- p.Asp444Glu Single submitter ⚠
- p.Asp62His Single submitter ⚠
- p.Asp62Val Single submitter ⚠
- p.Gln147Lys Single submitter ⚠
- p.Gln217Glu Single submitter ⚠
- p.Gln233His Single submitter ⚠
- p.Gln340Arg Single submitter ⚠
- p.Gln39Glu Single submitter ⚠
- p.Glu115Lys Single submitter ⚠
- p.Glu13Lys Single submitter ⚠
- p.Glu225Lys Single submitter ⚠
- p.Glu22Lys Single submitter ⚠
- p.Glu303Lys Single submitter ⚠
- p.Glu397Val Single submitter ⚠
- p.Glu476Gly Single submitter ⚠
- p.Glu477Lys Single submitter ⚠
- p.Glu91Lys Single submitter ⚠
- p.Gly103Glu Single submitter ⚠
- p.Gly108Val Single submitter ⚠
- p.Gly143Cys Single submitter ⚠
- p.Gly156Arg Single submitter ⚠
- p.Gly160Val Single submitter ⚠
- p.Gly237Ala Single submitter ⚠
- p.Gly311Arg Single submitter ⚠
- p.Gly31Ala Single submitter ⚠
- p.Gly334Val Single submitter ⚠
- p.Gly369Arg Single submitter ⚠
- p.Gly402Arg Single submitter ⚠
- p.Gly469Asp Single submitter ⚠
- p.His137Arg Single submitter ⚠
- p.Ile11Thr Single submitter ⚠
- p.Ile45Thr Single submitter ⚠
- p.Ile8Thr Single submitter ⚠
- p.Leu105Pro Single submitter ⚠
- p.Leu28Val Single submitter ⚠
- p.Leu36Phe Single submitter ⚠
- p.Lys494Arg Single submitter ⚠
- p.Pro181Leu Single submitter ⚠
- p.Pro208Thr Single submitter ⚠
- p.Ser102Pro Single submitter ⚠
- p.Ser107Cys Single submitter ⚠
- p.Ser110Leu Single submitter ⚠
- p.Ser247Asn Single submitter ⚠
- p.Ser254Arg Single submitter ⚠
- p.Ser339Asn Single submitter ⚠
- p.Ser412Leu Single submitter ⚠
- p.Ser447Pro Single submitter ⚠
- p.Ser475Leu Single submitter ⚠
- p.Ser488Cys Single submitter ⚠
- p.Thr226Ile Single submitter ⚠
- p.Thr234Pro Single submitter ⚠
- p.Thr26Arg Single submitter ⚠
- p.Thr313Ile Single submitter ⚠
- p.Thr450Arg Single submitter ⚠
- p.Thr66Ala Single submitter ⚠
- p.Thr88Lys Single submitter ⚠
- p.Tyr18Asn Single submitter ⚠
- p.Val152Ile Single submitter ⚠
- p.Val152Phe Single submitter ⚠
- p.Val242Leu Single submitter ⚠
- p.Val302Met Single submitter ⚠