CROT — 99 ClinVar variants

All ClinVar germline CROT variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 88 flagged for review →

1 Benign · 6 Likely benign · 92 Uncertain significance

Full CROT gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 88

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 45

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 43

The independent predictors disagree with each other — read with care.

All CROT variants

Benign 1

p.Glu83Asp Single submitter

Likely benign 6

c.1063-8A>G Single submitter
p.Ala397Val Single submitter
p.Arg187His Single submitter
p.Asn475Ser Single submitter
p.Ile371Thr Single submitter
p.Val168Ile Single submitter

Uncertain significance 92

c.116-1631C>T Single submitter
c.116-1651G>A Single submitter
c.116-1663C>A Single submitter
c.116-1686C>G Single submitter
p.Ala104Val Single submitter ⚠
p.Ala238Thr Single submitter ⚠
p.Ala328Gly Single submitter ⚠
p.Ala577Gly Single submitter ⚠
p.Ala580Pro Single submitter ⚠
p.Arg12Gln Single submitter ⚠
p.Arg160Gln Single submitter ⚠
p.Arg197Gly Single submitter ⚠
p.Arg252Gln Single submitter ⚠
p.Arg305His Single submitter ⚠
p.Arg389Gly Single submitter ⚠
p.Arg451His Single submitter ⚠
p.Arg451Pro Single submitter ⚠
p.Arg464Ser Single submitter ⚠
p.Arg479Gln Single submitter ⚠
p.Arg505His Single submitter ⚠
p.Arg570Thr Single submitter ⚠
p.Asn538Tyr Single submitter ⚠
p.Asp259Ala Single submitter ⚠
p.Asp343Asn Single submitter ⚠
p.Asp417Asn Single submitter ⚠
p.Asp527Glu Single submitter ⚠
p.Asp92Gly Single submitter ⚠
p.Cys578Ser Single submitter ⚠
p.Gln15Arg Single submitter ⚠
p.Gln270Arg Single submitter ⚠
p.Glu118Gly Single submitter ⚠
p.Glu123Lys Single submitter ⚠
p.Glu231Lys Single submitter ⚠
p.Glu279Gly Single submitter ⚠
p.Glu374Lys Single submitter ⚠
p.Glu453Asp Single submitter ⚠
p.Glu478Gly Single submitter ⚠
p.Glu516Gly Single submitter ⚠
p.Gly119Val Single submitter ⚠
p.Gly170Glu Single submitter ⚠
p.Gly186Arg Single submitter ⚠
p.Gly307Asp Single submitter ⚠
p.Gly405Ala Single submitter ⚠
p.Gly534Arg Single submitter ⚠
p.His225Leu Single submitter ⚠
p.His229Arg Single submitter ⚠
p.His229Leu Single submitter ⚠
p.His432Leu Single submitter ⚠
p.His449Tyr Single submitter ⚠
p.His560Arg Single submitter ⚠
p.Ile237Thr Single submitter ⚠
p.Ile269Asn Single submitter ⚠
p.Ile346Ser Single submitter ⚠
p.Ile346Thr Single submitter ⚠
p.Ile95Thr Single submitter ⚠
p.Leu133Ser Single submitter ⚠
p.Leu414Ile Single submitter ⚠
p.Leu512Phe Single submitter ⚠
p.Leu519Phe Single submitter ⚠
p.Leu529Val Single submitter ⚠
p.Met333Val Single submitter ⚠
p.Met469Thr Single submitter ⚠
p.Met558Thr Single submitter ⚠
p.Phe103Ser Single submitter ⚠
p.Phe180Val Single submitter ⚠
p.Phe404Leu Single submitter ⚠
p.Phe574Leu Single submitter ⚠
p.Pro115Leu Single submitter ⚠
p.Pro153Thr Single submitter ⚠
p.Pro214Thr Single submitter ⚠
p.Pro522Leu Single submitter ⚠
p.Pro528Ala Single submitter ⚠
p.Pro557Ala Single submitter ⚠
p.Ser272Asn Single submitter ⚠
p.Ser31Thr Single submitter ⚠
p.Ser473Phe Single submitter ⚠
p.Ser473Pro Single submitter ⚠
p.Thr303Ile Single submitter ⚠
p.Thr418Met Single submitter ⚠
p.Thr444Arg Single submitter ⚠
p.Thr452Ala Single submitter ⚠
p.Thr452Arg Single submitter ⚠
p.Trp136Cys Single submitter ⚠
p.Trp306Arg Single submitter ⚠
p.Tyr341His Single submitter ⚠
p.Tyr563Cys Single submitter ⚠
p.Val101Asp Single submitter ⚠
p.Val275Ile Single submitter ⚠
p.Val460Leu Single submitter ⚠
p.Val546Phe Single submitter ⚠
p.Val554Ala Single submitter ⚠
p.Val88Phe Single submitter ⚠