CRTAC1 — 101 ClinVar variants
All ClinVar germline CRTAC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 98 flagged for review →
4 Likely benign · 97 Uncertain significance
Full CRTAC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 98
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 51
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRTAC1 p.Ala373Pro Uncertain significance Single submitter
- CRTAC1 p.Arg108Trp Uncertain significance Single submitter
- CRTAC1 p.Arg153His Uncertain significance Single submitter
- CRTAC1 p.Arg178Cys Uncertain significance Single submitter
- CRTAC1 p.Arg293Gln Uncertain significance Single submitter
- CRTAC1 p.Arg346His Uncertain significance Single submitter
- CRTAC1 p.Arg381His Uncertain significance Single submitter
- CRTAC1 p.Arg403Gln Uncertain significance Single submitter
- CRTAC1 p.Arg436Gln Uncertain significance Single submitter
- CRTAC1 p.Arg532Gln Uncertain significance Single submitter
- CRTAC1 p.Asn166Ser Uncertain significance Single submitter
- CRTAC1 p.Asn438Ser Uncertain significance Single submitter
- CRTAC1 p.Asn554Ser Uncertain significance Single submitter
- CRTAC1 p.Asp396Asn Uncertain significance Single submitter
- CRTAC1 p.Asp413Glu Uncertain significance Single submitter
- CRTAC1 p.Asp415Glu Uncertain significance Single submitter
- CRTAC1 p.Asp478Asn Uncertain significance Single submitter
- CRTAC1 p.Asp533Asn Uncertain significance Single submitter
- CRTAC1 p.Glu390Lys Uncertain significance Single submitter
- CRTAC1 p.Glu655Lys Uncertain significance Single submitter
- CRTAC1 p.Gly201Ser Uncertain significance Single submitter
- CRTAC1 p.Gly221Val Uncertain significance Single submitter
- CRTAC1 p.Gly414Arg Uncertain significance Single submitter
- CRTAC1 p.Gly416Arg Uncertain significance Single submitter
- CRTAC1 p.Gly416Trp Uncertain significance Single submitter
- CRTAC1 p.Gly479Arg Uncertain significance Single submitter
- CRTAC1 p.Gly555Ser Uncertain significance Single submitter
- CRTAC1 p.Gly610Ser Uncertain significance Single submitter
- CRTAC1 p.Gly8Ser Uncertain significance Single submitter
- CRTAC1 p.Ile195Val Uncertain significance Single submitter
- CRTAC1 p.Ile248Leu Uncertain significance Single submitter
- CRTAC1 p.Leu526Met Uncertain significance Single submitter
- CRTAC1 p.Leu537Pro Uncertain significance Single submitter
- CRTAC1 p.Lys497Glu Uncertain significance Single submitter
- CRTAC1 p.Met417Arg Uncertain significance Single submitter
- CRTAC1 p.Met512Lys Uncertain significance Single submitter
- CRTAC1 p.Met522Val Uncertain significance Single submitter
- CRTAC1 p.Met558Lys Uncertain significance Single submitter
- CRTAC1 p.Phe363Ser Uncertain significance Single submitter
- CRTAC1 p.Ser162Arg Uncertain significance Single submitter
- CRTAC1 p.Ser162Asn Uncertain significance Single submitter
- CRTAC1 p.Ser324Gly Uncertain significance Single submitter
- CRTAC1 p.Ser656Thr Uncertain significance Single submitter
- CRTAC1 p.Tyr47His Uncertain significance Single submitter
- CRTAC1 p.Tyr584His Uncertain significance Single submitter
- CRTAC1 p.Val203Met Uncertain significance Single submitter
- CRTAC1 p.Val277Ala Uncertain significance Single submitter
- CRTAC1 p.Val434Ile Uncertain significance Single submitter
- CRTAC1 p.Val463Phe Uncertain significance Single submitter
- CRTAC1 p.Val576Ile Uncertain significance Single submitter
- CRTAC1 p.Val643Ile Uncertain significance Single submitter
Predictors split 47
The independent predictors disagree with each other — read with care.
- CRTAC1 p.Ala168Val Uncertain significance Single submitter
- CRTAC1 p.Ala281Val Uncertain significance Single submitter
- CRTAC1 p.Ala296Thr Uncertain significance Single submitter
- CRTAC1 p.Ala500Gly Uncertain significance Single submitter
- CRTAC1 p.Ala628Thr Likely benign Single submitter
- CRTAC1 p.Ala630Thr Uncertain significance Single submitter
- CRTAC1 p.Arg110Trp Uncertain significance Single submitter
- CRTAC1 p.Arg127Trp Uncertain significance Single submitter
- CRTAC1 p.Arg156Gln Uncertain significance Single submitter
- CRTAC1 p.Arg156Trp Uncertain significance Single submitter
- CRTAC1 p.Arg190Cys Uncertain significance Single submitter
- CRTAC1 p.Arg241Gln Uncertain significance Single submitter
- CRTAC1 p.Arg271Trp Uncertain significance Single submitter
- CRTAC1 p.Arg30Trp Uncertain significance Single submitter
- CRTAC1 p.Arg332Trp Uncertain significance Single submitter
- CRTAC1 p.Arg375Cys Uncertain significance Single submitter
- CRTAC1 p.Arg375His Uncertain significance Single submitter
- CRTAC1 p.Arg403Trp Uncertain significance Single submitter
- CRTAC1 p.Arg436Trp Uncertain significance Single submitter
- CRTAC1 p.Arg475Lys Uncertain significance Single submitter
- CRTAC1 p.Arg515Gln Uncertain significance Single submitter
- CRTAC1 p.Arg515Trp Uncertain significance Single submitter
- CRTAC1 p.Arg532Trp Uncertain significance Single submitter
- CRTAC1 p.Arg87Trp Uncertain significance Single submitter
- CRTAC1 p.Arg91Gln Uncertain significance Single submitter
- CRTAC1 p.Asn374Asp Uncertain significance Single submitter
- CRTAC1 p.Glu597Lys Uncertain significance Single submitter
- CRTAC1 p.Glu600Lys Uncertain significance Single submitter
- CRTAC1 p.Gly126Ser Uncertain significance Single submitter
- CRTAC1 p.Gly414Glu Uncertain significance Single submitter
- CRTAC1 p.Gly555Val Uncertain significance Single submitter
- CRTAC1 p.Ile193Val Uncertain significance Single submitter
- CRTAC1 p.Leu149Val Uncertain significance Single submitter
- CRTAC1 p.Leu432Met Uncertain significance Single submitter
- CRTAC1 p.Met512Ile Uncertain significance Single submitter
- CRTAC1 p.Phe257Leu Uncertain significance Single submitter
- CRTAC1 p.Phe412Leu Uncertain significance Single submitter
- CRTAC1 p.Pro33Ser Uncertain significance Single submitter
- CRTAC1 p.Pro571Leu Uncertain significance Single submitter
- CRTAC1 p.Thr25Asn Uncertain significance Single submitter
- CRTAC1 p.Thr275Ile Uncertain significance Single submitter
- CRTAC1 p.Thr39Asn Uncertain significance Single submitter
- CRTAC1 p.Thr506Met Uncertain significance Single submitter
- CRTAC1 p.Val167Met Uncertain significance Single submitter
- CRTAC1 p.Val517Met Uncertain significance Single submitter
- CRTAC1 p.Val606Met Uncertain significance Single submitter
- CRTAC1 p.Val97Ile Uncertain significance Single submitter
All CRTAC1 variants
Likely benign 4
- p.Ala622Thr Single submitter
- p.Ala628Thr Single submitter ⚠
- p.Arg220Gln Single submitter
- p.Arg378= Single submitter
Uncertain significance 97
- p.Ala168Val Single submitter ⚠
- p.Ala281Val Single submitter ⚠
- p.Ala296Thr Single submitter ⚠
- p.Ala373Pro Single submitter ⚠
- p.Ala500Gly Single submitter ⚠
- p.Ala630Thr Single submitter ⚠
- p.Arg108Trp Single submitter ⚠
- p.Arg110Trp Single submitter ⚠
- p.Arg127Trp Single submitter ⚠
- p.Arg153His Single submitter ⚠
- p.Arg156Gln Single submitter ⚠
- p.Arg156Trp Single submitter ⚠
- p.Arg178Cys Single submitter ⚠
- p.Arg190Cys Single submitter ⚠
- p.Arg241Gln Single submitter ⚠
- p.Arg271Trp Single submitter ⚠
- p.Arg293Gln Single submitter ⚠
- p.Arg30Trp Single submitter ⚠
- p.Arg332Trp Single submitter ⚠
- p.Arg346His Single submitter ⚠
- p.Arg375Cys Single submitter ⚠
- p.Arg375His Single submitter ⚠
- p.Arg381His Single submitter ⚠
- p.Arg403Gln Single submitter ⚠
- p.Arg403Trp Single submitter ⚠
- p.Arg436Gln Single submitter ⚠
- p.Arg436Trp Single submitter ⚠
- p.Arg475Lys Single submitter ⚠
- p.Arg515Gln Single submitter ⚠
- p.Arg515Trp Single submitter ⚠
- p.Arg532Gln Single submitter ⚠
- p.Arg532Trp Single submitter ⚠
- p.Arg87Trp Single submitter ⚠
- p.Arg91Gln Single submitter ⚠
- p.Asn166Ser Single submitter ⚠
- p.Asn374Asp Single submitter ⚠
- p.Asn438Ser Single submitter ⚠
- p.Asn554Ser Single submitter ⚠
- p.Asp396Asn Single submitter ⚠
- p.Asp413Glu Single submitter ⚠
- p.Asp415Glu Single submitter ⚠
- p.Asp478Asn Single submitter ⚠
- p.Asp533Asn Single submitter ⚠
- p.Glu390Lys Single submitter ⚠
- p.Glu597Lys Single submitter ⚠
- p.Glu600Lys Single submitter ⚠
- p.Glu655Lys Single submitter ⚠
- p.Gly126Ser Single submitter ⚠
- p.Gly201Ser Single submitter ⚠
- p.Gly221Val Single submitter ⚠
- p.Gly414Arg Single submitter ⚠
- p.Gly414Glu Single submitter ⚠
- p.Gly416Arg Single submitter ⚠
- p.Gly416Trp Single submitter ⚠
- p.Gly479Arg Single submitter ⚠
- p.Gly555Ser Single submitter ⚠
- p.Gly555Val Single submitter ⚠
- p.Gly610Ser Single submitter ⚠
- p.Gly8Ser Single submitter ⚠
- p.Ile193Val Single submitter ⚠
- p.Ile195Val Single submitter ⚠
- p.Ile248Leu Single submitter ⚠
- p.Leu149Val Single submitter ⚠
- p.Leu432Met Single submitter ⚠
- p.Leu526Met Single submitter ⚠
- p.Leu537Pro Single submitter ⚠
- p.Lys497Glu Single submitter ⚠
- p.Met417Arg Single submitter ⚠
- p.Met512Ile Single submitter ⚠
- p.Met512Lys Single submitter ⚠
- p.Met522Val Single submitter ⚠
- p.Met558Lys Single submitter ⚠
- p.Phe257Leu Single submitter ⚠
- p.Phe363Ser Single submitter ⚠
- p.Phe412Leu Single submitter ⚠
- p.Pro33Ser Single submitter ⚠
- p.Pro571Leu Single submitter ⚠
- p.Ser162Arg Single submitter ⚠
- p.Ser162Asn Single submitter ⚠
- p.Ser324Gly Single submitter ⚠
- p.Ser656Thr Single submitter ⚠
- p.Thr25Asn Single submitter ⚠
- p.Thr275Ile Single submitter ⚠
- p.Thr39Asn Single submitter ⚠
- p.Thr506Met Single submitter ⚠
- p.Tyr47His Single submitter ⚠
- p.Tyr584His Single submitter ⚠
- p.Val167Met Single submitter ⚠
- p.Val203Met Single submitter ⚠
- p.Val277Ala Single submitter ⚠
- p.Val434Ile Single submitter ⚠
- p.Val463Phe Single submitter ⚠
- p.Val517Met Single submitter ⚠
- p.Val576Ile Single submitter ⚠
- p.Val606Met Single submitter ⚠
- p.Val643Ile Single submitter ⚠
- p.Val97Ile Single submitter ⚠