CRTC3 — 87 ClinVar variants
All ClinVar germline CRTC3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 79 flagged for review →
2 Benign · 5 Likely benign · 80 Uncertain significance
Full CRTC3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 79
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 70
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRTC3 p.Ala156Ser Uncertain significance Single submitter
- CRTC3 p.Ala156Val Uncertain significance Single submitter
- CRTC3 p.Ala357Val Uncertain significance Single submitter
- CRTC3 p.Ala464Asp Uncertain significance Single submitter
- CRTC3 p.Ala475Gly Uncertain significance Single submitter
- CRTC3 p.Ala566Thr Uncertain significance Single submitter
- CRTC3 p.Arg242Gln Uncertain significance Single submitter
- CRTC3 p.Arg384Trp Uncertain significance Single submitter
- CRTC3 p.Asn126Ser Uncertain significance Single submitter
- CRTC3 p.Asn158His Uncertain significance Single submitter
- CRTC3 p.Asn495Lys Uncertain significance Single submitter
- CRTC3 p.Asn540Ser Uncertain significance Single submitter
- CRTC3 p.Asn596Ser Uncertain significance Single submitter
- CRTC3 p.Asp119Asn Uncertain significance Single submitter
- CRTC3 p.Gln184His Uncertain significance Single submitter
- CRTC3 p.Gln441Glu Uncertain significance Single submitter
- CRTC3 p.Gln480Leu Uncertain significance Single submitter
- CRTC3 p.Gln505Arg Uncertain significance Single submitter
- CRTC3 p.Gln522Glu Uncertain significance Single submitter
- CRTC3 p.Gln528His Uncertain significance Single submitter
- CRTC3 p.Gln52Arg Uncertain significance Single submitter
- CRTC3 p.Glu437Ala Uncertain significance Single submitter
- CRTC3 p.Glu583Lys Uncertain significance Single submitter
- CRTC3 p.Glu611Lys Uncertain significance Single submitter
- CRTC3 p.Gly150Glu Uncertain significance Single submitter
- CRTC3 p.Gly181Arg Uncertain significance Single submitter
- CRTC3 p.Gly210Val Uncertain significance Single submitter
- CRTC3 p.Gly260Ala Uncertain significance Single submitter
- CRTC3 p.Gly260Asp Uncertain significance Single submitter
- CRTC3 p.Gly381Ser Uncertain significance Single submitter
- CRTC3 p.Gly398Asp Uncertain significance Single submitter
- CRTC3 p.Gly501Arg Uncertain significance Single submitter
- CRTC3 p.Gly523Asp Uncertain significance Single submitter
- CRTC3 p.Gly542Arg Uncertain significance Single submitter
- CRTC3 p.Gly604Arg Uncertain significance Single submitter
- CRTC3 p.His402Pro Uncertain significance Single submitter
- CRTC3 p.His532Tyr Uncertain significance Single submitter
- CRTC3 p.His59Arg Uncertain significance Single submitter
- CRTC3 p.Ile318Leu Uncertain significance Single submitter
- CRTC3 p.Leu153Pro Uncertain significance Single submitter
- CRTC3 p.Leu237Met Uncertain significance Single submitter
- CRTC3 p.Leu431Pro Uncertain significance Single submitter
- CRTC3 p.Leu431Val Uncertain significance Single submitter
- CRTC3 p.Leu519Val Uncertain significance Single submitter
- CRTC3 p.Leu544Val Uncertain significance Single submitter
- CRTC3 p.Leu595Ile Uncertain significance Single submitter
- CRTC3 p.Met423Val Uncertain significance Single submitter
- CRTC3 p.Met507Val Uncertain significance Single submitter
- CRTC3 p.Phe483Tyr Uncertain significance Single submitter
- CRTC3 p.Pro105Arg Uncertain significance Single submitter
- CRTC3 p.Pro142Ala Uncertain significance Single submitter
- CRTC3 p.Pro287Ser Uncertain significance Single submitter
- CRTC3 p.Pro435Ser Uncertain significance Single submitter
- CRTC3 p.Pro457Thr Uncertain significance Single submitter
- CRTC3 p.Pro487Leu Uncertain significance Single submitter
- CRTC3 p.Ser135Asn Uncertain significance Single submitter
- CRTC3 p.Ser164Pro Uncertain significance Single submitter
- CRTC3 p.Ser262Leu Uncertain significance Single submitter
- CRTC3 p.Ser322Phe Uncertain significance Single submitter
- CRTC3 p.Ser343Phe Uncertain significance Single submitter
- CRTC3 p.Ser353Phe Uncertain significance Single submitter
- CRTC3 p.Ser476Phe Uncertain significance Single submitter
- CRTC3 p.Ser591Asn Uncertain significance Single submitter
- CRTC3 p.Thr336Met Uncertain significance Single submitter
- CRTC3 p.Thr394Met Uncertain significance Single submitter
- CRTC3 p.Thr412Ala Uncertain significance Single submitter
- CRTC3 p.Tyr179Cys Uncertain significance Single submitter
- CRTC3 p.Tyr418Cys Uncertain significance Single submitter
- CRTC3 p.Val390Ile Uncertain significance Single submitter
-
CRTC3 p.Arg463Ser
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 9
The independent predictors disagree with each other — read with care.
- CRTC3 p.Arg240His Uncertain significance Single submitter
- CRTC3 p.Arg90Cys Uncertain significance Single submitter
- CRTC3 p.Asn11Ile Uncertain significance Single submitter
- CRTC3 p.Asp560Tyr Uncertain significance Single submitter
- CRTC3 p.Glu17Asp Uncertain significance Single submitter
- CRTC3 p.His59Asp Uncertain significance Single submitter
- CRTC3 p.Ser301Cys Uncertain significance Single submitter
- CRTC3 p.Thr56Pro Uncertain significance Single submitter
- CRTC3 p.Val66Met Uncertain significance Single submitter
All CRTC3 variants
Likely benign 5
- p.Ala464Thr Single submitter
- p.Leu42= Single submitter
- p.Pro537Leu Single submitter
- p.Thr420Ala Single submitter
- p.Val575Met Single submitter
Uncertain significance 80
- p.Ala156Ser Single submitter ⚠
- p.Ala156Val Single submitter ⚠
- p.Ala357Val Single submitter ⚠
- p.Ala464Asp Single submitter ⚠
- p.Ala475Gly Single submitter ⚠
- p.Ala566Thr Single submitter ⚠
- p.Arg240His Single submitter ⚠
- p.Arg242Gln Single submitter ⚠
- p.Arg384Trp Single submitter ⚠
- p.Arg90Cys Single submitter ⚠
- p.Asn11Ile Single submitter ⚠
- p.Asn126Ser Single submitter ⚠
- p.Asn158His Single submitter ⚠
- p.Asn356del Single submitter
- p.Asn495Lys Single submitter ⚠
- p.Asn540Ser Single submitter ⚠
- p.Asn596Ser Single submitter ⚠
- p.Asp119Asn Single submitter ⚠
- p.Asp560Tyr Single submitter ⚠
- p.Gln184His Single submitter ⚠
- p.Gln441Glu Single submitter ⚠
- p.Gln480Leu Single submitter ⚠
- p.Gln505Arg Single submitter ⚠
- p.Gln522Glu Single submitter ⚠
- p.Gln528His Single submitter ⚠
- p.Gln52Arg Single submitter ⚠
- p.Glu17Asp Single submitter ⚠
- p.Glu437Ala Single submitter ⚠
- p.Glu583Lys Single submitter ⚠
- p.Glu611Lys Single submitter ⚠
- p.Gly150Glu Single submitter ⚠
- p.Gly181Arg Single submitter ⚠
- p.Gly210Val Single submitter ⚠
- p.Gly260Ala Single submitter ⚠
- p.Gly260Asp Single submitter ⚠
- p.Gly381Ser Single submitter ⚠
- p.Gly398Asp Single submitter ⚠
- p.Gly501Arg Single submitter ⚠
- p.Gly523Asp Single submitter ⚠
- p.Gly542Arg Single submitter ⚠
- p.Gly604Arg Single submitter ⚠
- p.His402Pro Single submitter ⚠
- p.His532Tyr Single submitter ⚠
- p.His59Arg Single submitter ⚠
- p.His59Asp Single submitter ⚠
- p.Ile318Leu Single submitter ⚠
- p.Leu153Pro Single submitter ⚠
- p.Leu237Met Single submitter ⚠
- p.Leu431Pro Single submitter ⚠
- p.Leu431Val Single submitter ⚠
- p.Leu519Val Single submitter ⚠
- p.Leu544Val Single submitter ⚠
- p.Leu595Ile Single submitter ⚠
- p.Met423Val Single submitter ⚠
- p.Met507Val Single submitter ⚠
- p.Phe483Tyr Single submitter ⚠
- p.Pro105Arg Single submitter ⚠
- p.Pro142Ala Single submitter ⚠
- p.Pro287Ser Single submitter ⚠
- p.Pro435Ser Single submitter ⚠
- p.Pro457Thr Single submitter ⚠
- p.Pro487Leu Single submitter ⚠
- p.Ser135Asn Single submitter ⚠
- p.Ser164Pro Single submitter ⚠
- p.Ser262Leu Single submitter ⚠
- p.Ser301Cys Single submitter ⚠
- p.Ser322Phe Single submitter ⚠
- p.Ser343Phe Single submitter ⚠
- p.Ser353Phe Single submitter ⚠
- p.Ser476Phe Single submitter ⚠
- p.Ser591Asn Single submitter ⚠
- p.Thr336Met Single submitter ⚠
- p.Thr394Met Single submitter ⚠
- p.Thr412Ala Single submitter ⚠
- p.Thr56Pro Single submitter ⚠
- p.Tyr179Cys Single submitter ⚠
- p.Tyr418Cys Single submitter ⚠
- p.Val390Ile Single submitter ⚠
- p.Val66Met Single submitter ⚠
- p.Arg463Ser No assertion criteria prostate cancer ⚠