CRY2 — 83 ClinVar variants
All ClinVar germline CRY2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 72 flagged for review →
2 Benign · 1 Likely benign · 80 Uncertain significance
Full CRY2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 72
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 54
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRY2 p.Ala12Val Uncertain significance Single submitter
- CRY2 p.Ala14Glu Uncertain significance Single submitter
- CRY2 p.Ala14Val Uncertain significance Single submitter
- CRY2 p.Ala16Pro Uncertain significance Single submitter
- CRY2 p.Ala260Val Uncertain significance Single submitter
- CRY2 p.Ala319Thr Uncertain significance Single submitter
- CRY2 p.Ala376Pro Uncertain significance Single submitter
- CRY2 p.Ala407Ser Uncertain significance Single submitter
- CRY2 p.Ala457Thr Uncertain significance Single submitter
- CRY2 p.Ala476Val Uncertain significance Single submitter
- CRY2 p.Ala593Asp Uncertain significance Single submitter
- CRY2 p.Ala8Val Uncertain significance Single submitter
- CRY2 p.Arg128Trp Uncertain significance Single submitter
- CRY2 p.Arg282His Uncertain significance Single submitter
- CRY2 p.Arg287Cys Uncertain significance Single submitter
- CRY2 p.Arg287Ser Uncertain significance Single submitter
- CRY2 p.Arg29His Uncertain significance Single submitter
- CRY2 p.Arg324Thr Uncertain significance Single submitter
- CRY2 p.Arg386Cys Uncertain significance Single submitter
- CRY2 p.Arg497Trp Uncertain significance Single submitter
- CRY2 p.Arg514Gln Uncertain significance Single submitter
- CRY2 p.Arg561His Uncertain significance Single submitter
- CRY2 p.Asn342Ser Uncertain significance Single submitter
- CRY2 p.Asn468Ser Uncertain significance Single submitter
- CRY2 p.Asp101Asn Uncertain significance Single submitter
- CRY2 p.Asp20Glu Uncertain significance Single submitter
- CRY2 p.Cys525Tyr Uncertain significance Single submitter
- CRY2 p.Gln368Arg Uncertain significance Single submitter
- CRY2 p.Gln505His Uncertain significance Single submitter
- CRY2 p.Glu200Lys Uncertain significance Single submitter
- CRY2 p.Gly355Val Uncertain significance Single submitter
- CRY2 p.Gly571Arg Uncertain significance Single submitter
- CRY2 p.His373Tyr Uncertain significance Single submitter
- CRY2 p.Leu224Ile Uncertain significance Single submitter
- CRY2 p.Lys353Glu Uncertain significance Single submitter
- CRY2 p.Lys560Arg Uncertain significance Single submitter
- CRY2 p.Pro13Arg Uncertain significance Single submitter
- CRY2 p.Pro166Thr Uncertain significance Single submitter
- CRY2 p.Pro586Ser Uncertain significance Single submitter
- CRY2 p.Ser538Leu Uncertain significance Single submitter
- CRY2 p.Thr145Ala Uncertain significance Single submitter
- CRY2 p.Thr145Met Uncertain significance Single submitter
- CRY2 p.Thr19Met Uncertain significance Single submitter
- CRY2 p.Thr4Ser Uncertain significance Single submitter
- CRY2 p.Thr83Ile Uncertain significance Single submitter
- CRY2 p.Trp289Cys Uncertain significance Single submitter
- CRY2 p.Tyr152Cys Uncertain significance Single submitter
- CRY2 p.Tyr253Cys Uncertain significance Single submitter
- CRY2 p.Tyr286His Uncertain significance Single submitter
- CRY2 p.Tyr54Cys Uncertain significance Single submitter
- CRY2 p.Val102Leu Uncertain significance Single submitter
- CRY2 p.Val112Ala Uncertain significance Single submitter
- CRY2 p.Val411Met Uncertain significance Single submitter
- CRY2 p.Val490Ile Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- CRY2 p.Ala345Val Uncertain significance Single submitter
- CRY2 p.Ala39Thr Uncertain significance Single submitter
- CRY2 p.Ala520Thr Uncertain significance Single submitter
- CRY2 p.Arg171Cys Uncertain significance Single submitter
- CRY2 p.Arg487Trp Uncertain significance Single submitter
- CRY2 p.Asn491Ser Uncertain significance Single submitter
- CRY2 p.Glu215Lys Uncertain significance Single submitter
- CRY2 p.Glu245Lys Uncertain significance Single submitter
- CRY2 p.Glu351Gly Uncertain significance Single submitter
- CRY2 p.Glu494Gln Uncertain significance Single submitter
- CRY2 p.Ile481Thr Uncertain significance Single submitter
- CRY2 p.Leu303Phe Uncertain significance Single submitter
- CRY2 p.Leu75Val Uncertain significance Single submitter
- CRY2 p.Met179Leu Uncertain significance Single submitter
- CRY2 p.Ser299Gly Uncertain significance Single submitter
- CRY2 p.Ser64Phe Uncertain significance Single submitter
- CRY2 p.Thr317Met Uncertain significance Single submitter
- CRY2 p.Val211Met Uncertain significance Single submitter
All CRY2 variants
Benign 2
- p.Ala12Glu Multiple submitters
- p.Gly269= Multiple submitters
Likely benign 1
- p.Val6Gly Single submitter
Uncertain significance 80
- c.37G>C Single submitter
- c.-5C>T Single submitter
- p.Ala12Val Single submitter ⚠
- p.Ala14Glu Single submitter ⚠
- p.Ala14Val Single submitter ⚠
- p.Ala16Pro Single submitter ⚠
- p.Ala260Val Single submitter ⚠
- p.Ala319Thr Single submitter ⚠
- p.Ala345Val Single submitter ⚠
- p.Ala376Pro Single submitter ⚠
- p.Ala39Thr Single submitter ⚠
- p.Ala407Ser Single submitter ⚠
- p.Ala457Thr Single submitter ⚠
- p.Ala476Val Single submitter ⚠
- p.Ala520Thr Single submitter ⚠
- p.Ala593Asp Single submitter ⚠
- p.Ala8Val Single submitter ⚠
- p.Arg128Trp Single submitter ⚠
- p.Arg171Cys Single submitter ⚠
- p.Arg282His Single submitter ⚠
- p.Arg287Cys Single submitter ⚠
- p.Arg287Ser Single submitter ⚠
- p.Arg29His Single submitter ⚠
- p.Arg324Thr Single submitter ⚠
- p.Arg386Cys Single submitter ⚠
- p.Arg487Trp Single submitter ⚠
- p.Arg497Trp Single submitter ⚠
- p.Arg514Gln Single submitter ⚠
- p.Arg561His Single submitter ⚠
- p.Arg9Leu Single submitter
- p.Asn342Ser Single submitter ⚠
- p.Asn468Ser Single submitter ⚠
- p.Asn491Ser Single submitter ⚠
- p.Asp101Asn Single submitter ⚠
- p.Asp20Glu Single submitter ⚠
- p.Cys525Tyr Single submitter ⚠
- p.Gln368Arg Single submitter ⚠
- p.Gln505His Single submitter ⚠
- p.Glu200Lys Single submitter ⚠
- p.Glu215Lys Single submitter ⚠
- p.Glu245Lys Single submitter ⚠
- p.Glu351Gly Single submitter ⚠
- p.Glu494Gln Single submitter ⚠
- p.Glu494Gly Single submitter
- p.Gly162Glu Single submitter
- p.Gly355Val Single submitter ⚠
- p.Gly571Arg Single submitter ⚠
- p.His373Tyr Single submitter ⚠
- p.Ile481Thr Single submitter ⚠
- p.Leu224Ile Single submitter ⚠
- p.Leu303Phe Single submitter ⚠
- p.Leu75Val Single submitter ⚠
- p.Lys353Glu Single submitter ⚠
- p.Lys560Arg Single submitter ⚠
- p.Met179Leu Single submitter ⚠
- p.Pro13Arg Single submitter ⚠
- p.Pro166Thr Single submitter ⚠
- p.Pro332Leu Single submitter
- p.Pro586Ser Single submitter ⚠
- p.Ser299Gly Single submitter ⚠
- p.Ser538Leu Single submitter ⚠
- p.Ser64Phe Single submitter ⚠
- p.Thr145Ala Single submitter ⚠
- p.Thr145Met Single submitter ⚠
- p.Thr19Met Single submitter ⚠
- p.Thr317Met Single submitter ⚠
- p.Thr4Ser Single submitter ⚠
- p.Thr83Ile Single submitter ⚠
- p.Trp289Cys Single submitter ⚠
- p.Tyr152Cys Single submitter ⚠
- p.Tyr253Cys Single submitter ⚠
- p.Tyr286His Single submitter ⚠
- p.Tyr54Cys Single submitter ⚠
- p.Tyr8His Single submitter
- p.Val102Leu Single submitter ⚠
- p.Val102Met Single submitter
- p.Val112Ala Single submitter ⚠
- p.Val211Met Single submitter ⚠
- p.Val411Met Single submitter ⚠
- p.Val490Ile Single submitter ⚠